Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Guralp Onur Ceyhan"'
Autor:
Hüseyin Erdinç Beşikcioğlu, Ümmügülsüm Yurteri, Linhan Ye, Fang Zhang, Alessandra Moretti, Ibrahim Halil Gürcinar, Alper Dogruöz, Didem Karakas, Helmut Friess, Guralp Onur Ceyhan, Rouzanna Istvanffy, Ihsan Ekin Demir
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103132- (2024)
Summary: The mandatory usage of extracellular matrix (ECM) gels in 3D cultures limits antibody penetration and increases background, while the removal of ECM gel causes disruption of morphology and sample loss. These factors pose challenges to effect
Externí odkaz:
https://doaj.org/article/58c8551257c34ae8bf2629f33e42aae3
Autor:
Alicia Sitte, Ruediger Goess, Tutku Tüfekçi, Ilaria Pergolini, Paulo Leonardo Pfitzinger, Eloísa Salvo-Romero, Carmen Mota Reyes, Sergey Tokalov, Okan Safak, Hendrik Steenfadt, Ibrahim H. Gürcinar, Ümmügülsüm Yurteri, Miriam Goebel-Stengel, Gemma Mazzuoli-Weber, Andreas Stengel, Mert Erkan, Helmut Friess, Rouzanna Istvanffy, Güralp Onur Ceyhan, Elke Demir, Ihsan Ekin Demir
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Mast cells are commonly found in pancreatic ductal adenocarcinoma (PDAC), yet their role in the disease remains uncertain. Although mast cells have been associated with depression in several diseases, their connection to PDAC in this context
Externí odkaz:
https://doaj.org/article/7f49bd20fa0a4a3886c295df3194b9a2
Autor:
Okan Safak, Shenghan Wang, Carmen Mota Reyes, Ibrahim Halil Gürcinar, Sergey Tokalov, Nedim Can Cevik, Kivanc Görgülü, Bengi Su Yilmaz, Emre Erdogan, Linhan Ye, Qiaolin Li, Elif Arik Sever, Samed Özer, Güldal Süyen, Helmut Friess, Güralp Onur Ceyhan, Rouzanna Istvanffy, Hana Algül, Ihsan Ekin Demir
Publikováno v:
Cancer Communications, Vol 44, Iss 1, Pp 178-182 (2024)
Externí odkaz:
https://doaj.org/article/f6002cc832d14136abf6f7b427ad84fe
Autor:
Xiaobo Wang, Rouzanna Istvanffy, Linhan Ye, Steffen Teller, Melanie Laschinger, Kalliope N. Diakopoulos, Kıvanç Görgülü, Qiaolin Li, Lei Ren, Carsten Jäger, Katja Steiger, Alexander Muckenhuber, Baiba Vilne, Kaan Çifcibaşı, Carmen Mota Reyes, Ümmügülsüm Yurteri, Maximilian Kießler, Ibrahim Halil Gürçınar, Maya Sugden, Saliha Elif Yıldızhan, Osman Uğur Sezerman, Sümeyye Çilingir, Güldal Süyen, Maximilian Reichert, Roland M. Schmid, Stefanie Bärthel, Rupert Oellinger, Achim Krüger, Roland Rad, Dieter Saur, Hana Algül, Helmut Friess, Marina Lesina, Güralp Onur Ceyhan, Ihsan Ekin Demir
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer, frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but insufficiently modeled in genetical
Externí odkaz:
https://doaj.org/article/de6bfa94aa5043158c58f7d898718cfc
Autor:
Erman Aytaç, Leyla Özer, Bilgi Baca, Emre Balık, Yersu Kapran, Orhun Cığ Taşkın, Başak Oyan Uluç, Mehmet Ufuk Abacıoğlu, Murat Gönenç, Yasemin Bölükbaşı, Barbaros E. Çil, Bülent Baran, Cem Aygün, Mehmet Erdem Yıldız, Kemal Ünal, Burçak Erkol, Tunç Yaltı, Uğur Özbek, Tan Attila, Nurdan Tözün, Bengi Gürses, Sibel Erdamar, Özlem Er, Nuran Beşe, Orhan Bilge, Güralp Onur Ceyhan, Nil Molinas Mandel, Uğur Selek, Cengiz Yakıcıer, Hülya Kayserili Karabey, Murat Saruç, Volkan Özben, Eren Esen, Emre Özoran, Erkan Vardareli, Levent Güner, İsmail Hamzaoğlu, Dursun Buğra, Tayfun Karahasanoğlu, The İstanbul Group
Publikováno v:
The Turkish Journal of Gastroenterology, Vol 33, Iss 8, Pp 627-663 (2022)
Externí odkaz:
https://doaj.org/article/3a4dc67bbb9c4476af188695c8366dbe
Autor:
Paulo L. Pfitzinger, Laura Fangmann, Kun Wang, Elke Demir, Engin Gürlevik, Bettina Fleischmann-Mundt, Jennifer Brooks, Jan G. D’Haese, Steffen Teller, Andreas Hecker, Moritz Jesinghaus, Carsten Jäger, Lei Ren, Rouzanna Istvanffy, Florian Kühnel, Helmut Friess, Güralp Onur Ceyhan, Ihsan Ekin Demir
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-15 (2020)
Abstract Background Nerve-cancer interactions are increasingly recognized to be of paramount importance for the emergence and progression of pancreatic cancer (PCa). Here, we investigated the role of indirect cholinergic activation on PCa progression
Externí odkaz:
https://doaj.org/article/b723c6b0993b4138b7a61f13032d92be
Autor:
Hande Asimgil, Utku Ertetik, Nedim Can Çevik, Menar Ekizce, Alper Doğruöz, Muazzez Gökalp, Elif Arık-Sever, Rouzanna Istvanffy, Helmut Friess, Güralp Onur Ceyhan, Ihsan Ekin Demir
Publikováno v:
JCI Insight, Vol 7, Iss 1 (2022)
KRAS mutations are the drivers of various cancers, including non–small cell lung cancer, colon cancer, and pancreatic cancer. Over the last 30 years, immense efforts have been made to inhibit KRAS mutants and oncogenic KRAS signaling using inhibito
Externí odkaz:
https://doaj.org/article/f39f13d6f97c4aabb71966d4b8c0c205
Autor:
Sabine Buhner, Hannes Hahne, Kerstin Hartwig, Qin Li, Sheila Vignali, Daniela Ostertag, Chen Meng, Gabriele Hörmannsperger, Breg Braak, Christian Pehl, Thomas Frieling, Giovanni Barbara, Roberto De Giorgio, Ihsan Ekin Demir, Güralp Onur Ceyhan, Florian Zeller, Guy Boeckxstaens, Dirk Haller, Bernhard Kuster, Michael Schemann
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193943 (2018)
The causes of gastrointestinal complaints in irritable bowel syndrome (IBS) remain poorly understood. Altered nerve function has emerged as an important pathogenic factor as IBS mucosal biopsy supernatants consistently activate enteric and sensory ne
Externí odkaz:
https://doaj.org/article/2441a57b189a441e8ece153c1da63545
Autor:
Eva Maria Kugler, Klaus eMichel, Florian eZeller, Ihsan Ekin Demir, Güralp Onur Ceyhan, Michael eSchemann, Gemma eMazzuoli-Weber
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
The particular location of myenteric neurons, sandwiched between the 2 muscle layers of the gut, implies that their somata and neurites undergo mechanical stress during gastrointestinal motility. Existence of mechanosensitive enteric neurons (MEN) is
Externí odkaz:
https://doaj.org/article/c6e1974801dd4a68b49ba9612caabd1f