Optimised isolation method for RNA extraction suitable for RNA sequencing from feline teeth collected in a clinical setting and at post mortem

Autor: Colin Farquharson, Guraa Bergkvist, Craig Johnson, Seungmee Lee, Urmi Trivedi

Publikováno v: Lee, S, Trivedi, U, Johnson, C, Farquharson, C & Bergkvist, G 2019, ' Optimised isolation method for RNA extraction suitable for RNA sequencing from feline teeth collected in a clinical setting and at post mortem ', Veterinary Research Communications, vol. 43, no. 1, pp. 17-27 . https://doi.org/10.1007/s11259-018-9739-8

Advanced next generation sequencing approaches have started to reveal the cellular and molecular complexity of the microenvironment in many tissues. It is challenging to obtain high quality RNA from mineralised tissues. We developed an optimised meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ae9a0604d6d2458dc94bb4f4410a9f
https://doi.org/10.1007/s11259-018-9739-8

Identification of tumour initiating cells in feline head and neck squamous cell carcinoma and evidence for gefitinib induced epithelial to mesenchymal transition

Autor: Lisa Y. Pang, A Cervantes-Arias, David Argyle, Guraa Bergkvist, Donald Yool, Rhona Muirhead

Publikováno v: The Veterinary Journal. 193:46-52

Feline oral squamous cell carcinoma is considered a highly invasive cancer that carries a high level of morbidity. Despite aggressive surgery, patients often succumb to disease, the tumour having inherent insensitivity to radiation and chemotherapy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec69728129be4ff920b2a4cc0427508
https://doi.org/10.1016/j.tvjl.2012.01.009

Epidermal growth factor receptor as a therapeutic target in veterinary oncology

Autor: Donald Yool, Guraa Bergkvist

Publikováno v: Veterinary and Comparative Oncology. 9:81-94

Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor that stimulates cell proliferation and survival and becomes dysregulated in a range of solid tumours in man. It is recognized as a key oncogenic driver and has become a favoured th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6640a564adb8c188cda723a0a8a9cef2
https://doi.org/10.1111/j.1476-5829.2010.00237.x