Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Guoyu Meng"'
Autor:
Wen Jin, Yuting Dai, Li Chen, Honghu Zhu, Fangyi Dong, Hongming Zhu, Guoyu Meng, Junmin Li, Saijuan Chen, Zhu Chen, Hai Fang, Kankan Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Acute promyelocytic leukemia (APL) represents a paradigm for targeted differentiation therapy, with a minority of patients experiencing treatment failure and even early death. We here report a comprehensive single-cell analysis of 16 APL pat
Externí odkaz:
https://doaj.org/article/8faf8f577f5841a1af926a0e17e57d1f
Autor:
Zhihui Li, Minghao Jiang, Junfei Wang, Zhiyi Zhuo, Shiyan Zhang, Yangxia Tan, Weiguo Hu, Hao Zhang, Guoyu Meng
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 12, Pp n/a-n/a (2023)
Abstract Background IGH::DUX4 is frequently observed in 4% B‐cell acute lymphoblastic leukaemia patients. Regarding the IGH::DUX4‐driven transactivation and alternative splicing, which are the main reasons behind this acute leukaemia outbreak, it
Externí odkaz:
https://doaj.org/article/5d0a982c50d54f1098642baae9d82455
Autor:
Hao Zhang, Guoyu Meng
Publikováno v:
Blood Science, Vol 4, Iss 3, Pp 161-163 (2022)
B-cell acute lymphoblastic leukemia (B-ALL) is a malignant tumor originating from B-lineage lymphoid precursor cells. The incidence of B-ALL is about 80% in childhood acute leukemia and 20% in adults. In recent years, with standardized treatment guid
Externí odkaz:
https://doaj.org/article/4245f90457644ae891bc1e1748db537d
Autor:
Hao Zhang, Nuo Cheng, Zhihui Li, Ling Bai, Chengli Fang, Yuwen Li, Weina Zhang, Xue Dong, Minghao Jiang, Yang Liang, Sujiang Zhang, Jianqing Mi, Jiang Zhu, Yu Zhang, Sai‐Juan Chen, Yajie Zhao, Xiang‐Qin Weng, Weiguo Hu, Zhu Chen, Jinyan Huang, Guoyu Meng
Publikováno v:
Cancer Communications, Vol 41, Iss 11, Pp 1116-1136 (2021)
Abstract Background Abnormal alternative splicing is frequently associated with carcinogenesis. In B‐cell acute lymphoblastic leukemia (B‐ALL), double homeobox 4 fused with immunoglobulin heavy chain (DUX4/IGH) can lead to the aberrant production
Externí odkaz:
https://doaj.org/article/7fca2b2f3c82432b857e2e6044af3125
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
The SARS-CoV-2 Omicron outbreak is ongoing in Shanghai, home to 25 million population. Here, we presented a novel mathematical model to evaluate the Omicron spread and Zero-COVID strategy. Our model provided important parameters, the average quaranti
Externí odkaz:
https://doaj.org/article/14c21e3a23c74a2baef274239fe0c2e2
Publikováno v:
Blood Science, Vol 2, Iss 1, Pp 7-10 (2020)
Abstract. PML nuclear bodies (NBs), which are increasingly recognized as the central hub of many cellular signaling events, are superassembled spherical complexes with diameters of 0.1–2 μm. Recent studies reveal that RING tetramerization and B1-b
Externí odkaz:
https://doaj.org/article/09343ed61f5049cda4ff287f1bd5b63e
Autor:
Yuwen Li, Xiaodan Ma, Zhiming Chen, Haiyan Wu, Pengran Wang, Wenyu Wu, Nuo Cheng, Longhui Zeng, Hao Zhang, Xun Cai, Sai-Juan Chen, Zhu Chen, Guoyu Meng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Promyelocytic leukemia protein (PML) is the scaffolding protein that organizes PML nuclear bodies. Here the authors determine the crystal structure of a PML B1-box multimer and characterise the oligomerisation behaviour of the PML RBCC construct and
Externí odkaz:
https://doaj.org/article/476343b2924041758754a532fd02840f
Autor:
Pengran Wang, Shirine Benhenda, Haiyan Wu, Valérie Lallemand-Breitenbach, Tao Zhen, Florence Jollivet, Laurent Peres, Yuwen Li, Sai-Juan Chen, Zhu Chen, Hugues de Thé, Guoyu Meng
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Promyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear
Externí odkaz:
https://doaj.org/article/af84ac66c1354f56901c8f3934d5f6be
Autor:
Wen-Fang Wang, Li Yan, Zhao Liu, Lan-Xuan Liu, Jian Lin, Zhi-Yin Liu, Xiong-Ping Chen, Wu Zhang, Zi-Zhen Xu, Ting Shi, Jun-Min Li, Yi-Lei Zhao, Guoyu Meng, Yi Xia, Jian-Yong Li, Jiang Zhu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The transcriptional repressor Blimp-1 has an important role in B-cell differentiation. Here the authors show that lymphoma-associated Blimp-1 mutants are selectively recognized by HSP70-Hrd1, which leads to their accelerated degradation and propose H
Externí odkaz:
https://doaj.org/article/1ecd06a77cbb42a28310878c9d65a39a
Autor:
Xuan Li, Sarah Thome, Xiaodan Ma, Mamta Amrute-Nayak, Alison Finigan, Lauren Kitt, Leanne Masters, John R. James, Yuguang Shi, Guoyu Meng, Ziad Mallat
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Microtubules regulate activation of the NLRP3 inflammasome, but the underlying molecular mechanism is unclear. Here the authors show that MARK4 binds NLRP3 and shuttles it to the microtubule-organizing centre to promote optimal inflammasome activatio
Externí odkaz:
https://doaj.org/article/b75b1e786f494ff79643fc1b0ffb5763