Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Guoxian Wu"'
Publikováno v:
World Journal of Surgical Oncology, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background The aberrant expression of circular RNAs (circRNAs) plays vital roles in the advancement of human cancers, including gastric cancer (GC). In this study, the functions of circRNA ring finger protein 111 (circ-RNF111) in GC were inv
Externí odkaz:
https://doaj.org/article/57b3513e2fb14a63b70043941b1fe028
Autor:
Huimin Li, Anqi Li, Ying Qian, Bowei Jiang, Jinxing Luo, Bo Peng, Xinghui Liu, Guoxian Wu, Kai Wang
Publikováno v:
SID Symposium Digest of Technical Papers. 52:1067-1070
Publikováno v:
SID Symposium Digest of Technical Papers. 52:795-798
Autor:
Marika Nespi, Elizabeth A. Burton, Heidi Carias, Adhirai Marimuthu, Glenn Michelson, Gabriel Tinoco, Rafe Shellooe, Andrew J. Wagner, Prabha N. Ibrahim, Laura Sanftner, Garson Tsang, Guoxian Wu, Wayne Spevak, Jack Lin, Anthony F. Shields, Jonathan C. Trent, Gaston Habets, Paul Severson, Rashmi Chugh, Oscar Alcantar, Amita Patnaik, Ying Zhang, Athanasios C. Tsiatis, Todd Ewing, Kerry Inokuchi, Gideon Bollag, James Tsai, Hamid Rezaei, William D. Tap, Bernice Matusow, Katrina Chan, Chao Zhang
Publikováno v:
JAMA Oncol
Importance Many cancer subtypes, including KIT-mutant gastrointestinal stromal tumors (GISTs), are driven by activating mutations in tyrosine kinases and may initially respond to kinase inhibitors but frequently relapse owing to outgrowth of heteroge
Autor:
Marika Nespi, Elizabeth A. Burton, Gideon Bollag, Bernice Matusow, Raf Sciot, Guoxian Wu, Jasmien Wellens, Patrick Schöffski, Jasmien Cornillie, Maria Debiec-Rychter, Gaston Habets, Chao Zhang, Yemarshet K. Gebreyohannes, Jack Lin, Agnieszka Wozniak
Publikováno v:
Clinical and experimental medicine. 19(2)
The purpose of the present study was to investigate the in vitro and in vivo activity of PLX9486, a tyrosine kinase inhibitor (TKI) targeting both primary KIT exon 9 and 11 and secondary exon 17 and 18 mutations in gastrointestinal stromal tumors (GI
Autor:
K. B. Nolop, Garson Tsang, Yan Ma, Heidi Carias, D. Fong, Marika Nespi, Peter Hirth, Rafe Shellooe, Elizabeth A. Burton, Paul S. Lin, Jason Walters, Wayne Spevak, Todd Ewing, Ben Powell, Gideon Bollag, Hanna Cho, Womack Patrick, Bernice Matusow, Ying Zhang, Guoxian Wu, Jiazhong Zhang, Hamid Rezaei, Gary Conard Visor, Hoa Nguyen, Laura Sanftner, Brian L. West, Prabha N. Ibrahim, Gaston Habets, Weiru Wang, Jack Lin, Adhirai Marimuthu, James Tsai, Chao Zhang, Songyuan Shi, Emily Light
Publikováno v:
Nature. 526:583-586
Oncogenic activation of BRAF fuels cancer growth by constitutively promoting RAS-independent mitogen-activated protein kinase (MAPK) pathway signalling. Accordingly, RAF inhibitors have brought substantially improved personalized treatment of metasta
Publikováno v:
The Journal of Organic Chemistry. 63:5368-5371
Autor:
Guoxian Wu, Garson Tsang, Gaston Habets, Chao Zhang, Paul S. Lin, Dean R. Artis, Marika Nespi, Jiazhong Zhang, Elizabeth A. Burton, Hoa Nguyen, Angela Oh, Adhirai Marimuthu, Wayne Spevak, Gideon Bollag, Gregory H Tesch, Rafe Shellooe, Bernice Matusow, Prabha N. Ibrahim, Peter Hirth, Ying Zhang, Brian L. West, Ryan Bremer, Clarence R. Hurt, Kam Y. J. Zhang, Heidi Carias, Ben Powell, K. B. Nolop
Inflammation and cancer, two therapeutic areas historically addressed by separate drug discovery efforts, are now coupled in treatment approaches by a growing understanding of the dynamic molecular dialogues between immune and cancer cells. Agents th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13beba63af32ac3d497883ca2b5e3e1
https://europepmc.org/articles/PMC3619323/
https://europepmc.org/articles/PMC3619323/
Autor:
Jiazhong Zhang, Prabha N. Ibrahim, Emily Light, Jack Lin, Yan Ma, Garson Tsang, Chao Zhang, Guoxian Wu, Songyuan Shi, Hoa Nguyen, Todd Ewing, Bernice Wong, Adhirai Marimuthu, James Tsai, Marika Nespi, Elizabeth A. Burton, Wayne Spevak, Ben Powell, Peter Hirth, Gaston Habets, Rafe Shellooe, Ying Zhang, Brian L. West, Hanna Cho, Gideon Bollag
Publikováno v:
Molecular Cancer Therapeutics. 10:A229-A229
Selective inhibitors of BRAF such as vemurafenib (PLX4032) and GSK2118436 show remarkable efficacy in melanoma patients with tumors harboring BRAF V600 mutations. However these compounds paradoxically activate the MAPK pathway in RAS-mutant cells and
Autor:
Chao Zhang, Ibrahim, Prabha N., Jiazhong Zhang, Burton, Elizabeth A., Habets, Gaston, Ying Zhang, Powell, Ben, West, Brian L., Matusow, Bernice, Tsang, Garson, Shellooe, Rafe, Carias, Heidi, Hoa Nguyen, Marimuthu, Adhirai, Zhang, Kam Y. J., Oh, Angela, Bremer, Ryan, Hurt, Clarence R., Artis, Dean R., Guoxian Wu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 4/2/2013, Vol. 110 Issue 14, p5689-5694, 6p