Výsledky vyhledávání

Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy

Autor: Yue Jiang, Yuxia Luan, Mengzhu Zhang, Guoxia Jin, Hailong Tian

Publikováno v: Journal of Colloid and Interface Science. 587:358-366

Chemodynamic therapy (CDT) utilizes Fenton catalysts to convert intracellular hydrogen peroxide (H2O2) into cytotoxic hydroxyl radical (OH∙) for tumor therapy, but endogenous H2O2 is usually insufficient to achieve satisfactory tumor therapy effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03d5f5cfd26708454e996116e83a36e4
https://doi.org/10.1016/j.jcis.2020.12.028

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Exploration of Recombinant Fusion Proteins YAPO and YAPL as Carrier Proteins for Glycoconjugate Vaccine Design against Streptococcus pneumoniae Infection

Autor: Subo Wang, Guoxia Jin, Guofeng Gu, Chenghe Xiong, Guirong Wang, Shaojie Feng

Publikováno v: ACS Infectious Diseases. 6:2181-2191

Pneumolysin (Ply), pneumococcal surface protein A (PspA), and pneumococcal surface adhesin A (PsaA) are promising cell surface protein antigen targets for Streptococcus pneumoniae (Spn) vaccine development. Herein, we designed and recombined two fusi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ea58c22a85730fd084a6fb1ac0040aa
https://doi.org/10.1021/acsinfecdis.0c00260

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Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from Streptococcus pneumonia serotype 23F

Autor: Guofeng Gu, Hong Wang, Guoxia Jin, Zonggang Chen, Siqiang Li

Publikováno v: RSC Advances. 10:30110-30114

Glucose-1-phosphate thymidylyltransferase (Cps23FL) from Streptococcus pneumonia serotype 23F is the initial enzyme that catalyses the thymidylyl transfer reaction in prokaryotic deoxythymidine diphosphate-L-rhamnose (dTDP-Rha) biosynthetic pathway.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::287758ee412d46f38d4ec933e0de1127
https://doi.org/10.1039/d0ra05799a

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Biochemical studies of a β-1,4-rhamnoslytransferase from Streptococcus pneumonia serotype 23F

Autor: Guofeng Gu, Zonggang Chen, Guoxia Jin, Zhongwu Guo, Chenghe Xiong, Hong Wang, Siqiang Li

Publikováno v: Organic & Biomolecular Chemistry. 17:1071-1075

A new β-rhamnoslytransferase Cps23FT from Streptococcus pneumonia serotype 23F was expressed and characterized. Its enzymatic activity and function were confirmed for the first time by utilizing enzymatically prepared dTDP-Rha and chemically synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c078d954ba1ed9fe731108b91966501
https://doi.org/10.1039/c8ob02795a

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Chlorambucil prodrug-participating catanionic aggregates for sustained drug release and improved antitumour activity

Autor: Yue Jiang, Guoxia Jin, Xu Hu, Jing Zhang, Yuxia Luan

Publikováno v: Journal of Molecular Liquids. 274:556-561

A prodrug-participating catanionic system was developed for effective delivery of the chemotherapeutic agent chlorambucil (CLB). The catanionic aggregates were easily formed by mixing as-synthesized cationic CLB prodrug, N-(2-amino-ethyl)-4-{4-[bis-(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cb46b59232715f9a51470074a43bc90
https://doi.org/10.1016/j.molliq.2018.10.165

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A preclinical evaluation of cytarabine prodrug nanofibers assembled from cytarabine-lauric acid conjugate toward solid tumors

Autor: Guoxia Jin, Wei Jiang, Xu Hu, Ruiling Liu, Yue Jiang, Jilian Wu, Yuxia Luan

Publikováno v: International Journal of Pharmaceutics. 552:111-118

Cytarabine (Ara-C) has become cornerstones for the treatment of hatmatological malignancies for several decades; however, it still faces serious challenges in clinical applications due to its side effects such as hand foot syndrome (HFS) and stomatit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75dbdba87844e25113897d7936c6a95
https://doi.org/10.1016/j.ijpharm.2018.09.043

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