Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Guowu Wu"'
Autor:
Chenfei Zhou, Jinling Jiang, Xiaojun Xiang, Hongli Liu, Guowu Wu, Ruichao Zeng, Tong Lu, Mengqi Zhang, Yuteng Shen, Min Hong, Jun Zhang
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-14 (2024)
Abstract Background Blocking cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) shows substantial antitumor efficacy. Here, we report the preclinical data and outcomes of a first-in-human phase 1a trial of JS007, a novel anti-CTLA-4 antibody, in ad
Externí odkaz:
https://doaj.org/article/31cceefc2b274d07b0c1bbd9ea2b4b65
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
In the past, immune checkpoint inhibitors (ICIs) like camrelizumab have been associated with rheumatic immune-related adverse events (irAEs).To prevent serious adverse consequences, early diagnosis of rheumatic irAEs is crucial. A 40-year-old patient
Externí odkaz:
https://doaj.org/article/c9dfd319f058488bac96eb79834a47eb
Autor:
Siming Liu, Chuan Huang, Chunhui Huang, Yaqi Huang, Yonghuan Yu, Guowu Wu, Fengqiu Guo, Ying Jiang, Shanhe Wan, Zhengguang Zhu, Yuanxin Tian, Jianghua Zhu, Jiajie Zhang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Clinical treatment by FDA-approved ROS1/ALK inhibitor Crizotinib significantly improved the therapeutic outcomes. However, the emergence of drug resistance, especially driven by acquired mutations, have become an inevitable problem and worsened the c
Externí odkaz:
https://doaj.org/article/0b5c5c07baf041f39b81de8cf3a2b193
Autor:
Ying Jiang, Chunhui Huang, Yaqi Huang, Lifan Long, Guowu Wu, Fengqiu Guo, Chuan Huang, Siming Liu, Zhengguang Zhu, Shaoyu Wu, Zhonghuang Li, Jiajie Zhang, Shanhe Wan
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1501 (2023)
Targeting the epidermal growth factor receptor (EGFR) is one of the potential ways to treat glioblastoma (GBM). In this study, we investigate the anti-GBM tumor effects of the EGFR inhibitor SMUZ106 in both in vitro and in vivo conditions. The effect
Externí odkaz:
https://doaj.org/article/cf092b77dd624b77bb00da65f249eb02
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 299-314 (2020)
Because most studies have focused on the intrinsic carcinogenic pathways of tumors, the underlying role of N6-methyladenosine (m6A) methylation in tumor immune microenvironment (TIME) remains elusive. Herein, we systematically explored the correlatio
Externí odkaz:
https://doaj.org/article/920c838f74cb49729f9e1d8957759922
Autor:
Lilan Yi, Ping Huang, Yinfang Gu, Guowu Wu, Xiaofang Zou, Longhua Guo, Chunling Wen, Junlin Zhu, Dongdong Zhao
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundThe prevalence of patients newly diagnosed with early-stage lung adenocarcinoma (LUAD) is growing alongside significant advances in screening approaches. This study aimed to construct ferroptosis-related gene score (FRGscore) for predicting
Externí odkaz:
https://doaj.org/article/f6966782e3ba4ae09df88d8ef068f7e6
Autor:
Jun Chen, Wei Zhang, Yu Zhang, Tao Xu, Ying Tian, Ming Zhou, Jie Jiang, Minhua Ye, Liwei Zhang, Yunpeng Liu, Wenxiang Wang, Lin Wu, Shun Lu, Haohui Fang, Guohua Yu, Wenqun Xing, Qixun Chen, Xingya Li, Nong Yang, Wentao Fang, Yunchao Huang, Jichun Liu, Lijie Tan, Xiaosheng Hang, Wengang Zhang, Xun Zhang, Aihong Zhong, Shanqing Li, Guowu Wu, Xiaoyan Kang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/5f8a6ce9deb94bb488cdc1a7da63690f
Autor:
Xue Hou, Chengzhi Zhou, Guowu Wu, Wen Lin, Zhanhong Xie, Haibo Zhang, Jiqun Yi, Zheng Peng, Lifeng Yin, Chi Ma, Likun Chen
Publikováno v:
Journal of Thoracic Oncology. 18:769-779
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24c781434c14b4e2c9025c981d25f346
https://doi.org/10.1016/j.jtho.2023.01.083
https://doi.org/10.1016/j.jtho.2023.01.083
Autor:
Guowu Wu, Xiaofang Zou, Yiwen Lin, Yuhua Meng, Shuanglong Chen, Yinfang Gu, Longhua Guo, Lilan Yi, Hongmei Dong, Lu Wang, Dianzheng Zhang, Hao Zhang
Background Protein arginine methyltransferase 5 (PRMT5), a member of protein arginine methyltransferases, is an enzyme catalyzing the methylation of arginine residuals of histones and non-histone proteins to serve as one of many critical posttranslat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfc976a6cee6deb35c711c9c1636d438
https://doi.org/10.21203/rs.3.rs-2539484/v1
https://doi.org/10.21203/rs.3.rs-2539484/v1
Publikováno v:
OncoTargets and therapy
Chemotherapy is the mainstay of treatment for advanced small cell esophageal carcinoma (SCEC) characterized by poor prognosis. Preclinical studies demonstrated that apatinib has the potential to enhance the efficacy of conventional chemotherapeutic d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0034ae1ae84f42d42cb1a450c9c4be37
http://europepmc.org/articles/PMC7987322
http://europepmc.org/articles/PMC7987322