Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Guotong Fu"'
Autor:
Lingyun Long, Jiyang Yu, Peter Vogel, Nicole M. Chapman, Hongling Huang, Junmin Peng, Boer Xie, Cliff Guy, Anil Kc, Seon Ah Lim, Isabel Risch, Yanyan Wang, Mingming Niu, Yuxin Li, Hongbo Chi, Jon P. Connelly, Jana L. Raynor, Wei Su, Yong-Dong Wang, Yogesh Dhungana, Hong Wang, Hao Shi, Guotong Fu, Peipei Zhou, Jordy Saravia, Shondra M. Pruett-Miller, Jun Wei
Publikováno v:
Nature
Nutrients are emerging regulators of adaptive immunity1. Selective nutrients interplay with immunological signals to activate mechanistic target of rapamycin complex 1 (mTORC1), a key driver of cell metabolism2–4, but how these environmental signal
Autor:
Yong-Dong Wang, Suzanne Jackowski, Xueyan Liu, Anthony Sheyn, Randall Wakefield, Chenxi Qian, Amanda Johnson, Hongbo Chi, Camenzind G. Robinson, Lingyun Long, Jun Wei, Peipei Zhou, Scott A. Brown, Sherri Rankin, Jiyang Yu, Hongling Huang, Yogesh Dhungana, Hao Shi, Nicole M. Chapman, Guotong Fu, Clifford S. Guy, Gustavo Palacios, Anil Kc
Publikováno v:
Nature. 595:724-729
T follicular helper (TFH) cells are crucial for B cell-mediated humoral immunity1. Although transcription factors such as BCL6 drive the differentiation of TFH cells2,3, it is unclear whether and how post-transcriptional and metabolic programs enforc
Autor:
Jiajie Hu, Xiaolei Zhang, Yan Wu, Zixuan Sheng, Dongsheng Yu, Guotong Fu, Zongyou Pan, Yishan Chen, Heng Sun, Jun Dai, Hongwei Ouyang, Yafei Wang, Linrong Lu
Publikováno v:
Osteoarthritis and Cartilage. 28:112-121
Summary Objective To identify the role of misshapen/NIK-related kinase (MINK1) in age-related Osteoarthritis (OA) and injury-induced OA, and the effects of enhanced TGFβ signaling in these progresses. Design The effect of MINK1 was analyzed with MIN
Autor:
Guotong, Fu, Clifford S, Guy, Nicole M, Chapman, Gustavo, Palacios, Jun, Wei, Peipei, Zhou, Lingyun, Long, Yong-Dong, Wang, Chenxi, Qian, Yogesh, Dhungana, Hongling, Huang, Anil, Kc, Hao, Shi, Sherri, Rankin, Scott A, Brown, Amanda, Johnson, Randall, Wakefield, Camenzind G, Robinson, Xueyan, Liu, Anthony, Sheyn, Jiyang, Yu, Suzanne, Jackowski, Hongbo, Chi
Publikováno v:
Nature
T follicular helper (Tfh) cells are crucial for B cell-mediated humoral immunity(1). Although transcription factors, such as Bcl6, drive Tfh cell differentiation(2,3), whether and how posttranscriptional and metabolic programs enforce Tfh cell progra
Autor:
Wei Huang, Qin Xu, Xiawei Li, Jingjing Liang, Dan Li, Mingzhu Zheng, Linrong Lu, Xuexiao Jin, Jun Lyu, Guotong Fu, Di Wang, Ting Xu, Jun Lou
Publikováno v:
Oncotarget
// Jun Lou 1,2,* , Xiawei Li 1,2,* , Wei Huang 1,2 , Jingjing Liang 1,2 , Mingzhu Zheng 1,2 , Ting Xu 1,2 , Jun Lyu 1,2 , Dan Li 1,2 , Qin Xu 1,2 , Xuexiao Jin 1,2 , Guotong Fu 1,2 , Di Wang 1,2 and Linrong Lu 1,2 1 Institute of Immunology, Zhejiang
Autor:
Di Wang, Shunli Dong, Xuetao Cao, Linrong Lu, Xuexiao Jin, Yuanjun Qiu, Guotong Fu, Yuehai Ke, Hu Hu, Qin Xu, Harvey Cantor, Xiang Gao, Ting Xu, Jianli Wang
Publikováno v:
The Journal of Experimental Medicine
Fu et al. demonstrate that reactive oxygen species (ROS)–sensing molecule misshapen/NIK-related kinase 1 (MINK1) can specifically suppress Th 17 cell differentiation through direct phosphorylation of SMAD2. This study provides the mechanism of how
Autor:
Qin Xu, Linrong Lu, Zhuoyu Wen, Xuexiao Jin, Richard D Sloan, Jun Lou, Lie Wang, Guotong Fu, Mingzhu Zheng, Hu Hu, Deepak Rohila, Songquan Wu, Xiang Gao
Publikováno v:
Xu, Q, Jin, X, Zheng, M, Rohila, D, Fu, G, Wen, Z, Lou, J, Wu, S, Sloan, R, Wang, L, Hu, H, Gao, X & Lu, L 2019, ' Phosphatase PP2A is essential for T H 17 differentiation ', Proceedings of the National Academy of Sciences, vol. 116, no. 3, pp. 982-987 . https://doi.org/10.1073/pnas.1807484116
Phosphatase PP2A expression levels are positively correlated to the clinical severity of systemic lupus erythematosus (SLE) and IL17A cytokine overproduction, indicating a potential role of PP2A in controlling T H 17 differentiation and inflammation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da85430f30e633daad948f8d3b79cf33
https://europepmc.org/articles/PMC6338861/
https://europepmc.org/articles/PMC6338861/
Autor:
Jiyang Yu, Hongling Huang, Peipei Zhou, Jordy Saravia, Chenxi Qian, Lingyun Long, Nicole M. Chapman, Gustavo Palacios, Yogesh Dhungana, Hao Shi, Guotong Fu, Jana L. Raynor, Yong-Dong Wang, Hongbo Chi, Jun Wei, Shaofeng Liu
Publikováno v:
Cell. 184:1245-1261.e21
How early events in effector T cell (TEFF) subsets tune memory T cell (TMEM) responses remains incompletely understood. Here, we systematically investigated metabolic factors in fate determination of TEFF and TMEM cells using in vivo pooled CRISPR sc
Autor:
Qin Xu, Xuexiao Jin, Mingzhu Zheng, Rohila, Deepak, Guotong Fu, Zhuoyu Wen, Jun Lou, Songquan Wu, Sloan, Richard, Lie Wang, Hu Hu, Xiang Gao, Linrong Lu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 1/15/2019, Vol. 116 Issue 3, p982-987, 6p