Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Guoquan Wan"'
Autor:
Xiao Li, Jia Wang, Qianqian Wang, Tianwen Luo, Xuejiao Song, Guoquan Wan, Zhanzhan Feng, Xiaojie He, Qian Lei, Ying Xu, Xinyu You, Luoting Yu, Lidan Zhang, Lifeng Zhao
Publikováno v:
Heliyon, Vol 9, Iss 5, Pp e15152- (2023)
Angiogenesis plays a critical role in the survival, progression and metastasis of malignant tumors. Multiple factors are known to induce tumor angiogenesis, vascular endothelial growth factor (VEGF) is the most important one. Lenvatinib is an oral mu
Externí odkaz:
https://doaj.org/article/01b6a89a18a640eaa8a293645a25b8a1
Autor:
Qiangsheng Zhang, Xinyi Chen, Xi Hu, Xianjie Duan, Guoquan Wan, Lu Li, Qiang Feng, Yiqian Zhang, Ningyu Wang, Luoting Yu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 147, Iss , Pp 112617- (2022)
The histone lysine methyltransferase EZH2 has been implicated as a key component in cancer development. Up to date, there are only a few EZH2 covalent inhibitors. In this study, a new series of 3-acrylamido-2-methyl-N-((2-oxo-1,2-dihydropyridin-3-yl)
Externí odkaz:
https://doaj.org/article/21a49f020aef41e1b917222cc250ef8b
Publikováno v:
Expert Opinion on Therapeutic Patents. 33:293-308
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f1286bb63ac7163be07ad0ff09d5d4d
https://doi.org/10.1080/13543776.2023.2206018
https://doi.org/10.1080/13543776.2023.2206018
Autor:
Qiangsheng Zhang, Xinyi Chen, Jiaying Cao, Wan Yang, Guoquan Wan, Qiang Feng, Shuyan Zhou, Hongling Yang, Ningyu Wang, Zhihao Liu, Hongtao Xiao, Yongxia Zhu, Luoting Yu
Publikováno v:
Journal of Medicinal Chemistry. 66:1725-1741
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e948a148dae8afb46a8d8454b23a4add
https://doi.org/10.1021/acs.jmedchem.2c01370
https://doi.org/10.1021/acs.jmedchem.2c01370
Autor:
Guoquan Wan, Zhanzhan Feng, Qiangsheng Zhang, Xiao Li, Kai Ran, Huan Feng, Tianwen Luo, Shuyan Zhou, Chang Su, Wei Wei, Ningyu Wang, Chao Gao, Lifeng Zhao, Luoting Yu
Publikováno v:
Journal of medicinal chemistry. 65(24)
The activation of the STAT signal after incubation with the HDAC inhibitor represents a key mechanism causing resistance to HDAC inhibitors in some solid tumor cells, while the FGFR inhibitor could downregulate the level of pSTAT3. Inspired by the th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a63ddadbf5594e2849b5dd9e5ae3797
https://pubmed.ncbi.nlm.nih.gov/36449947
https://pubmed.ncbi.nlm.nih.gov/36449947
Autor:
Yongxia Zhu, Qiangsheng Zhang, Luoting Yu, Ning-Yu Wang, Zhihao Liu, Lu Li, Qiang Feng, Lidan Zhang, Guoquan Wan, Xi Hu
Publikováno v:
Chemical communications (Cambridge, England). 57(24)
By targeting the unique Cys663 of EZH2, SKLB-0335 displays high paralog-selectivity on EZH2. Biochemical studies show that SKLB-0335 can covalently bind to EZH2 at its S-adenosylmethionine (SAM) pocket and inhibit H3K27Me3. SKLB-0335 could be an effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eeb8ddb60800e1536b228a5a42d2df2
https://pubmed.ncbi.nlm.nih.gov/33623946
https://pubmed.ncbi.nlm.nih.gov/33623946
Autor:
Zhanzhan Feng, Jun Zeng, Wei Wei, Wang Xiang, Kai Ran, Xiang Hu, Ning-Yu Wang, Xiaojie He, Luoting Yu, Zhihao Liu, Guoquan Wan
Publikováno v:
European journal of medicinal chemistry. 220
Aberrant signaling of fibroblast growth factor receptors (FGFRs) has been identified as a driver of tumorigenesis and the development of many solid tumors, making FGFRs a compelling target for anticancer therapy. Herein, we describe the design and sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e460ca2aa5f19da678c177287508284
https://pubmed.ncbi.nlm.nih.gov/33940465
https://pubmed.ncbi.nlm.nih.gov/33940465
Publikováno v:
CAAI Transactions on Intelligence Technology, Vol 9, Iss 1, Pp 142-152 (2024)
Abstract As one of the most effective methods to improve the accuracy and robustness of speech tasks, the audio–visual fusion approach has recently been introduced into the field of Keyword Spotting (KWS). However, existing audio–visual keyword s
Externí odkaz:
https://doaj.org/article/c7a25b40115c416f90fa823ed45ae3d0
Publikováno v:
Shuiwen dizhi gongcheng dizhi, Vol 51, Iss 1, Pp 167-178 (2024)
Both the Shandong Plain in China and the Greater Houston Area in the United States have land subsidence problems that were caused by excessive groundwater pumping. Houston has accumulated more than 100 years of monitoring results and more than 50 yea
Externí odkaz:
https://doaj.org/article/79abffeedfd842f98310aec8d94c6a75