Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Guoliang Qing"'
Autor:
Minhui Ye, Yingzhe Fang, Lu Chen, Zemin Song, Qing Bao, Fei Wang, Hao Huang, Jin Xu, Ziwen Wang, Ruijing Xiao, Meng Han, Song Gao, Hudan Liu, Baishan Jiang, Guoliang Qing
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Tumor cells must rewire nucleotide synthesis to satisfy the demands of unbridled proliferation. Meanwhile, they exhibit augmented reactive oxygen species (ROS) production which paradoxically damages DNA and free deoxy-ribonucleoside triphosp
Externí odkaz:
https://doaj.org/article/866c66e4e62441a38ed7fc6dc890f73f
Autor:
Qilong Li, Hao Guo, Jin Xu, Xinlu Li, Donghai Wang, Ying Guo, Guoliang Qing, Pieter Van Vlierberghe, Hudan Liu
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108571- (2024)
Summary: DHX15 has been implicated in RNA splicing and ribosome biogenesis, primarily functioning as an RNA helicase. To systematically assess the cellular role of DHX15, we conducted proteomic analysis to investigate the landscape of DHX15 interacto
Externí odkaz:
https://doaj.org/article/093867c9e2064328970a9c7b5cd25ba1
Autor:
Hao Guo, Jin Xu, Peiqi Xing, Qilong Li, Donghai Wang, Chao Tang, Bruno Palhais, Juliette Roels, Jiaxu Liu, Sa Pan, Jinyan Huang, Zhaoqi Liu, Ping Zhu, Tom Taghon, Guoliang Qing, Pieter Van Vlierberghe, Hudan Liu
Publikováno v:
Haematologica, Vol 108, Iss 8 (2023)
RNA-binding proteins (RBP) have emerged as essential regulators that control gene expression and modulate multiple cancer traits. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from transformation of T-cel
Externí odkaz:
https://doaj.org/article/8870cd7ba2c146f6ad6aea5a9e5e3dbc
Publikováno v:
Cell Insight, Vol 2, Iss 1, Pp 100075- (2023)
RNA N6-methyladenosine (m6A) has been identified as the most common, abundant and conserved internal modification in RNA transcripts, especially within eukaryotic messenger RNAs (mRNAs). Accumulating evidence demonstrates that RNA m6A modification ex
Externí odkaz:
https://doaj.org/article/81344bed6ca14701ac59cfd491819af1
Autor:
Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
While inhibition of the EZH2 methyltransferase activity has been used for targeting EZH2, its role in cancer progression remains unclear. Here, the authors use neuroblastoma and small cell lung carcinoma model systems and reveal the crosstalk between
Externí odkaz:
https://doaj.org/article/f716c9a52727454d9fd1cd4164df5d4e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Recombination activating genes 1 (Rag1) and Rag2 are expressed in immature lymphocytes and essential for generating the vast repertoire of antigen receptors. Yet, the mechanisms governing the transcription of Rag1 and Rag2 remain to be fully determin
Externí odkaz:
https://doaj.org/article/8e63eff09edb476aa798ca51fb303e18
Autor:
Hexiu Su, Juncheng Hu, Liang Huang, Yang Yang, Morgan Thenoz, Anna Kuchmiy, Yufeng Hu, Peng Li, Hui Feng, Yu Zhou, Tom Taghon, Pieter Van Vlierberghe, Guoliang Qing, Zhichao Chen, Hudan Liu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
T-acute lymphoblastic leukemia is an aggressive cancer. Here the authors provide insights into the functional role of SHQ1, an H/ACA snoRNP assembly factor involved in snRNA pseudouridylation, in T-lymphoblastic leukemia cell survival through regulat
Externí odkaz:
https://doaj.org/article/be84c2167969446dbc4de6875a3ebd48
Autor:
Juncheng Hu, Tianci Wang, Jin Xu, Sanyun Wu, Liyuan Wang, Hexiu Su, Jue Jiang, Ming Yue, Jingchao Wang, Donghai Wang, Peng Li, Fuling Zhou, Yu Liu, Guoliang Qing, Hudan Liu
Publikováno v:
Haematologica, Vol 106, Iss 7 (2020)
T-cell acute lymphoblastic leukemias (T-ALLs) are aggressive and heterogeneous hematologic tumors resulting from the malignant transformation of T-cell progenitors. The major challenges in the treatments of T-ALL are dose-limiting toxicities of chemo
Externí odkaz:
https://doaj.org/article/b9ea615bd7cd428d9371a0b5fd41b754
Autor:
Qin You, BS, Hexiu Su, BS, Jingchao Wang, MS, Jue Jiang, MS, Guoliang Qing, PhD, Hudan Liu, PhD
Publikováno v:
Journal of Bio-X Research, Vol 1, Iss 1, Pp 32-40 (2018)
Abstract. T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous group of hematological tumors composed of distinct subtypes that vary in their genetic abnormalities. In the past decade, large-scale genomic analysis has shed new light on prov
Externí odkaz:
https://doaj.org/article/3c5392c56ad848f0b5fa1750c7fbc6e1
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3819-3832 (2017)
Most tumor cells exhibit obligatory demands for essential amino acids (EAAs), but the regulatory mechanisms whereby tumor cells take up EAAs and EAAs promote malignant transformation remain to be determined. Here, we show that oncogenic MYC, solute c
Externí odkaz:
https://doaj.org/article/6f89a9b10db141889c0ea13258bd5c37