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Identification by High-Throughput Screening of Viridin Analogs as Biochemical and Cell-Based Inhibitors of the Cell Cycle–Regulated Nek2 Kinase

Autor: Navdeep K. Sahota, Samantha Burns, Daniel G. Hayward, Guojie Mao, Paul Workman, Ian Collins, Eilis Byrne, Lisa Pickard, Yvette Newbatt, Wynne Aherne, Andrew M. Fry

Publikováno v: SLAS Discovery. 15:918-927

Nek2 is a serine/threonine protein kinase that localizes to the centrosome and is implicated in mitotic regulation. Overexpression of Nek2 induces premature centrosome separation and nuclear defects indicative of mitotic errors, whereas depletion of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1905cc4756330a37326dfb364ad6bbdd
https://doi.org/10.1177/1087057110376537

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The role of MAP65-1 in microtubule bundling duringZinniatracheary element formation

Autor: Guojie Mao, John H. Doonan, Henrik Buschmann, Clive W. Lloyd

Publikováno v: Journal of Cell Science. 119:753-758

The MAP65 family of microtubule-associated proteins performs various functions at different stages of the cell cycle and differentiation. In this study, we have investigated the synchronous transdifferentiation of Zinnia mesophyll cells into trachear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ab10ddc1101806f441468ee5bee8e8
https://doi.org/10.1242/jcs.02813

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Modulated targeting of GFP-AtMAP65-1 to central spindle microtubules during division

Autor: John H. Doonan, Clive W. Lloyd, Grant Calder, Guojie Mao, Jordi Chan

Publikováno v: The Plant Journal. 43:469-478

AtMAP65-1 bundles cortical microtubules and we examined how this property is regulated during division in time-lapse studies of Arabidopsis suspension cells expressing GFP-AtMAP65-1. Spindle fluorescence is diffuse during metaphase, restored to the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2db698a9266d5a6e188e784cbacc8f1
https://doi.org/10.1111/j.1365-313x.2005.02464.x

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Drosophila Mgr, a Prefoldin subunit cooperating with von Hippel Lindau to regulate tubulin stability

Autor: David M. Glover, Doris McLean, Guojie Mao, Salud Llamazares, Maria Giovanna Riparbelli, Nathalie Delgehyr, Uta Wieland, Hélène Rangone, Nikola S. Dzhindzhev, Giuliano Callaini, Xavier Pinson, Cayetano Gonzalez

Mutations in Drosophila merry-go-round (mgr) have been known for over two decades to lead to circular mitotic figures and loss of meiotic spindle integrity. However, the identity of its gene product has remained undiscovered. We now show that mgr enc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b39662de70238c939d5d45b6f48782e
https://resolver.caltech.edu/CaltechAUTHORS:20200807-170354525

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Klp10A, a microtubule-depolymerizing kinesin-13, cooperates with CP110 to control Drosophila centriole length

Autor: Jingyan Fu, Nathalie Delgehyr, Brian D. M. Tom, David M. Glover, Maria Giovanna Riparbelli, Hélène Rangone, Giuliano Callaini, Guojie Mao

Publikováno v: Current biology : CB. 22(6)

Klp10A is a kinesin-13 of Drosophila melanogaster that depolymerizes cytoplasmic microtubules [1]. In interphase, it promotes microtubule catastrophe [2, 3, 4]; in mitosis, it contributes to anaphase chromosome movement by enabling tubulin flux [1, 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c4eead9ae12c05baeb3d6353397404
https://pubmed.ncbi.nlm.nih.gov/22365849

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Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

Autor: Samantha L. Wattam, Yuu Kimata, Andrew M. Fry, Guojie Mao, Catherine Lindon, Michelle J. Hayes, Hiroyuki Yamano

Publikováno v: Nature cell biology. 8(6)

The temporal control of mitotic protein degradation remains incompletely understood. In particular, it is unclear why the mitotic checkpoint prevents the anaphase-promoting complex/cyclosome (APC/C)-mediated degradation of cyclin B and securin in ear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d96a9242f2c52f8256b5a17a1ce4ba
https://pubmed.ncbi.nlm.nih.gov/16648845

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