Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Guohui Shang"'
Autor:
Yang Liu, Guohui Shang, Xuran Zhang, Fuyong Liu, Chi Zhang, Zhihao Li, Jing Jia, Yan Xu, Zhaojing Zhang, Shangdong Yang, Baixue Zhou, Yingying Luan, Yanyang Huang, Yue Peng, Tianyi Han, Ying He, Hong Zheng
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Epigenetic modulations lead to changes in gene expression, including DNA methylation, histone modifications, and noncoding RNAs. In recent years, epigenetic modifications have been related to the pathogenesis of different types of cancer, cardiovascu
Externí odkaz:
https://doaj.org/article/5b69f19a42ff464a83e9ef1b2d36c897
Autor:
Xuyan Peng, Guohui Shang, Wenqing Wang, Xiaowen Chen, Qiyong Lou, Gang Zhai, Dongliang Li, Zhenyu Du, Yali Ye, Xia Jin, Jiangyan He, Yi Zhang, Zhan Yin
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1444-1455 (2017)
1α,25(OH)2D3 (vitamin D3) is crucial for mineral homeostasis in mammals, but the precise effects of 1α,25(OH)2D3 in adipose tissue remain to be clarified in vivo. The initial 25-hydroxylation is catalyzed by liver microsomal cytochrome P450 2R1 (CY
Externí odkaz:
https://doaj.org/article/f7e5deab129141e1882809c523bac849
Autor:
Meiting Yang, Xiaorong Li, Zizi Tian, Lulu Ma, Jun Ma, Yunlong Liu, Guohui Shang, Ailing Liang, Wei Wu, Zhongzhou Chen
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3368
Volume 24
Issue 4
Pages: 3368
Adenine N6 methylation in DNA (6mA) is a well-known epigenetic modification in bacteria, phages, and eukaryotes. Recent research has identified the Mpr1/Pad1 N-terminal (MPN) domain-containing protein (MPND) as a sensor protein that may recognize DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33cfc0514850528eecc3a563539bd811
Autor:
Yuhang Zhang, Xuyan Peng, Mengjiao Xue, Jingjing Liu, Guohui Shang, Mingjun Jiang, Dandan Chen, Baixue Liu, Yuxuan Wang, Xiaolin Jia, Jianqing Xu, Fengyan Zhang, Yanzhong Hu
Publikováno v:
Biogerontology.
SARS-Cov-2 infection, which has caused the COVID-19 global pandemic, triggers cellular senescence. In this study, we investigate the role of the SARS-COV-2 spike protein (S-protein) in regulating the senescence of RPE cells. The results showed that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6b90ef11be58bc32383bcee52e332cd
https://doi.org/10.1007/s10522-023-10019-0
https://doi.org/10.1007/s10522-023-10019-0
Autor:
Baixue Liu, Yuxuan Wang, Hongmei Mu, Mingjun Jiang, Guohui Shang, Xuhui Liu, Yingwei Lu, Xiaolin Jia, Xuyan Peng, Mengjiao Xue, Dan-Dan Chen, Fengyan Zhang, Yanzhong Hu
Publikováno v:
Aging (Albany NY)
The senescence of retinal pigment epithelial (RPE) cells is associated with age-related macular degeneration (AMD), a leading cause of blindness in the world. HSP90 is a predominant chaperone that regulates cellular homeostasis under divergent physio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90f0e5e2da894cafb0ec304e6e521ce
http://europepmc.org/articles/PMC8457597
http://europepmc.org/articles/PMC8457597
Autor:
Jianfang Gui, Xia Jin, Jiangyan He, Gang Zhai, Zhan Yin, Yao Lu, Zhen-Yu Du, Guohui Shang, Dong-Liang Li, Qiyong Lou, Chuang Shi, Jianfei Huang
Publikováno v:
Journal of Molecular Cell Biology
The endocrine regulatory roles of the hypothalamic–pituitary–adrenocortical axis on anxiety-like behavior and metabolic status have been found throughout animal taxa. However, the precise effects of the balancing adrenal corticosteroid biosynthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4911bc1ca1b5f9c9fa6ebe726ef81fd
http://europepmc.org/articles/PMC7232124
http://europepmc.org/articles/PMC7232124
Autor:
Lulu, Ma, Hongyun, Lu, Zizi, Tian, Meiting, Yang, Jun, Ma, Guohui, Shang, Yunlong, Liu, Mengjia, Xie, Guoguo, Wang, Wei, Wu, Ziding, Zhang, Shaodong, Dai, Zhongzhou, Chen
Publikováno v:
Journal of Biological Chemistry. 298:101671
Human AlkB homolog 6, ALKBH6, plays key roles in nucleic acid damage repair and tumor therapy. However, no precise structural and functional information are available for this protein. In this study, we determined atomic resolution crystal structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8ac0e62d2b259b87fcf41a60ae0f93
https://doi.org/10.1016/j.jbc.2022.101671
https://doi.org/10.1016/j.jbc.2022.101671
Autor:
Yao Lu, Guohui Shang, Gang Zhai, Pin Nie, Xia Jin, Tingting Shu, Zhan Yin, Yuguo Xia, Jiangyan He
Publikováno v:
Endocrinology. 159:3549-3562
Cytochrome P450 (Cyp)17A1 has both 17α-hydroxylase and 17,20-lyase activities, which are involved in the steroidogenic pathway that produces androgens and estrogens. Previously, a phenotype of all-male cyp17a1-deficient zebrafish generated by transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78ebbe672df822ff16a3eff4a81c23b
https://doi.org/10.1210/en.2018-00551
https://doi.org/10.1210/en.2018-00551
Autor:
Wenqing Wang, Zhen-Yu Du, Yi Zhang, Gang Zhai, Xia Jin, Dong-Liang Li, Yali Ye, Zhan Yin, Guohui Shang, Qiyong Lou, Xuyan Peng, Xiaowen Chen, Jiangyan He
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1444-1455 (2017)
1α,25(OH)2D3 (vitamin D3) is crucial for mineral homeostasis in mammals, but the precise effects of 1α,25(OH)2D3 in adipose tissue remain to be clarified in vivo. The initial 25-hydroxylation is catalyzed by liver microsomal cytochrome P450 2R1 (CY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ce6172d695d4c7fba3226893656817
https://doi.org/10.1016/j.celrep.2017.04.066
https://doi.org/10.1016/j.celrep.2017.04.066
Autor:
Xia Jin, Gang Zhai, Peng Xuyan, Jiangyan He, Han Wang, Cheng Ji, Qiyong Lou, Guohui Shang, Zhan Yin, Yonglin Ruan
Publikováno v:
Biology of reproduction. 101(4)
In recent studies, luteinizing hormone (LH) was reported to play important roles in oocyte maturation. However, the mechanism by which LH signaling, especially regarding the steroidogenesis process, affects oocyte maturation has not been clarified. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10162af95854d7582d9d56b51097835b
https://pubmed.ncbi.nlm.nih.gov/31322169
https://pubmed.ncbi.nlm.nih.gov/31322169