Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Guofeng Meng"'
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-11 (2023)
Abstract Recently, increasing studies are indicating a close association between dysregulated enhancers and neurodegenerative diseases, such as Alzheimer’s disease (AD). However, their contributions were poorly defined for lacking direct links to d
Externí odkaz:
https://doaj.org/article/f9bae67f89aa45b99cf30995d3aae76a
Autor:
Pengfei Qin, Yakun Pang, Wenhong Hou, Ruiqing Fu, Yingchi Zhang, Xuefei Wang, Guofeng Meng, Qifa Liu, Xiaofan Zhu, Ni Hong, Tao Cheng, Wenfei Jin
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-17 (2021)
Abstract Single-cell RNA sequencing provides exciting opportunities to unbiasedly study hematopoiesis. However, our understanding of leukemogenesis was limited due to the high individual differences. Integrated analyses of hematopoiesis and leukemoge
Externí odkaz:
https://doaj.org/article/a225aab84c74476f966ff4ba73d8dcfb
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Guizhi has the pharmacological activity of anti-inflammatory. However, the effect mechanism of Guizhi against nephrotic syndrome (NS) remains unclear. A network pharmacological approach with experimental verification in vitro and in vivo
Externí odkaz:
https://doaj.org/article/b66516c163054778a0e049e0e2a98cf7
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 5, Pp 1371-1376 (2019)
PacBio sequencing is a powerful approach to study DNA or RNA sequences in a longer scope. It is especially useful in exploring the complex structural variants generated by random integration or multiple rearrangement of endogenous or exogenous sequen
Externí odkaz:
https://doaj.org/article/3278a960ac204eff92acc32b47cbb151
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Plasmacytoid dendritic cells (pDC) are an essential immune microenvironment component. They have been reported for crucial roles in linking the adaptive and immune systems. However, the prognostic role of the pDC in breast cancer (BRCA) was controver
Externí odkaz:
https://doaj.org/article/eeef2434e598448bb0c4b80f9f88e4e6
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
The causal mechanism of Alzheimer's disease is extremely complex. Achieving great statistical power in association studies usually requires a large number of samples. In this work, we illustrated a different strategy to identify AD risk genes by clus
Externí odkaz:
https://doaj.org/article/1093a015fc11456d9a839da41b91ca6c
Autor:
Guofeng Meng, Hongkang Mei
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Background: The pathogenesis of Alzheimer's disease is associated with dysregulation at different levels from transcriptome to cellular functioning. Such complexity necessitates investigations of disease etiology to be carried out considering multipl
Externí odkaz:
https://doaj.org/article/734fa0129b034eda9cd335130ea23007
Autor:
Jingjun Li, Jing Ma, Guofeng Meng, Hong Lin, Sharon Wu, Jamie Wang, Jie Luo, Xiaohong Xu, David Tough, Matthew Lindon, Inmaculada Rioja, Jing Zhao, Hongkang Mei, Rab Prinjha, Zhong Zhong
Publikováno v:
Stem Cell Research, Vol 17, Iss 2, Pp 212-221 (2016)
Neural stem cells and progenitor cells (NPCs) are increasingly appreciated to hold great promise for regenerative medicine to treat CNS injuries and neurodegenerative diseases. However, evidence for effective stimulation of neuronal production from e
Externí odkaz:
https://doaj.org/article/b0fe28873175464cb62a89e4c26a66ef
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150624 (2016)
Aging, as a complex biological process, is accompanied by the accumulation of functional loses at different levels, which makes age to be the biggest risk factor to many neurological diseases. Even following decades of investigation, the process of a
Externí odkaz:
https://doaj.org/article/7e8c26fe33f849d68ea2d2f64edf5d38
Publikováno v:
Phytotherapy Research.