Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Guofei Cui"'
Autor:
Shanshan Deng, Xinjun Lu, Xue Wang, Binyong Liang, Hongwei Xu, Doris Yang, Guofei Cui, Andrew Yonemura, Honor Paine, Yi Zhou, Yi Zhang, Maria Maddalena Simile, Francesco Urigo, Matthias Evert, Diego F. Calvisi, Benjamin L. Green, Xin Chen
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-11 (2024)
Abstract TBX3 behaves as a tumor suppressor or oncoprotein across cancer. However, TBX3 function remains undetermined in intrahepatic cholangiocarcinoma (iCCA), a deadly primary liver malignancy with few systemic treatment options. This study sought
Externí odkaz:
https://doaj.org/article/904e8d75b78a4941a72af5c5e04ec7b8
Autor:
Yi Zhou, Guofei Cui, Hongwei Xu, Joanne Chun, Doris Yang, Zheng Zhang, Lihui Yang, Jingxiao Wang, Meijuan Wan, Diego F. Calvisi, Shumei Lin, Xin Chen, Haichuan Wang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-9 (2023)
Abstract Hepatocellular carcinoma (HCC) is a deadly malignancy with high genetic heterogeneity. TP53 mutation and c-MET activation are frequent events in human HCCs. Here, we discovered that the simultaneous mutations in TP53 and activation of c-MET
Externí odkaz:
https://doaj.org/article/50c8d9e46b1e429bb2b167e784a197cc
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010985 (2023)
UPF-1-UPF-2-UPF-3 complex-orchestrated nonsense-mediated mRNA decay (NMD) is a well-characterized eukaryotic cellular surveillance mechanism that not only degrades aberrant transcripts to protect the integrity of the transcriptome but also eliminates
Externí odkaz:
https://doaj.org/article/b7ebad41f537431eb50e11affa9344d0
Autor:
Xinjun Lu, Shanshan Deng, Jiejie Xu, Benjamin L. Green, Honghua Zhang, Guofei Cui, Yi Zhou, Yi Zhang, Hongwei Xu, Fapeng Zhang, Rui Mao, Sheng Zhong, Thorsten Cramer, Matthias Evert, Diego F. Calvisi, Yukai He, Chao Liu, Xin Chen
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Many patients with hepatocellular carcinoma (HCC) do not respond to the first-line immune checkpoint inhibitor treatment. Immunization with effective cancer vaccines is an attractive alternative approach to immunotherapy. However, its efficacy remain
Externí odkaz:
https://doaj.org/article/0120b966f8424bdb9d9719e9d5c72fb1
Autor:
Alexander Scheiter, Katja Evert, Lucas Reibenspies, Antonio Cigliano, Katharina Annweiler, Karolina Müller, Laura‐Maria‐Giovanna Pöhmerer, Hongwei Xu, Guofei Cui, Timo Itzel, Silvia Materna‐Reichelt, Andrea Coluccio, Kamran Honarnejad, Andreas Teufel, Christoph Brochhausen, Frank Dombrowski, Xin Chen, Matthias Evert, Diego F. Calvisi, Kirsten Utpatel
Publikováno v:
Molecular Oncology, Vol 16, Iss 5, Pp 1091-1118 (2022)
Aberrant activation of the phosphoinositide 3‐kinase (PI3K)/AKT/mTOR and Ras/mitogen‐activated protein kinase (MAPK) pathways is a hallmark of hepatocarcinogenesis. In a subset of hepatocellular carcinomas (HCCs), PI3K/AKT/mTOR signaling dysregul
Externí odkaz:
https://doaj.org/article/db2315a1864e41beaeb3a952e323cea0
Autor:
Xiao Liu, Ahai Chen, Angélica Caicedo-Casso, Guofei Cui, Mingjian Du, Qun He, Sookkyung Lim, Hang J. Kim, Christian I. Hong, Yi Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Circadian clocks control daily rhythms of molecular and physiological activities. Here, the authors show that the interaction between proteins FRQ and CK1, rather than FRQ stability, is a major rate-limiting step in circadian period determination in
Externí odkaz:
https://doaj.org/article/dbbfd0b2ae6044ad9025f01804098213
Autor:
Xiao Liu, Ahai Chen, Angélica Caicedo-Casso, Guofei Cui, Mingjian Du, Qun He, Sookkyung Lim, Hang J. Kim, Christian I. Hong, Yi Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/1c22cf365a6b4c00841af286d955bf65
Autor:
Yi Zhang, Hongwei Xu, Guofei Cui, Binyong Liang, Xiangzheng Chen, Sungjin Ko, Silvia Affo, Xinhua Song, Yi Liao, Jianguo Feng, Pan Wang, Haichuan Wang, Meng Xu, Jingxiao Wang, Giovanni M. Pes, Silvia Ribback, Yong Zeng, Aatur Singhi, Robert F. Schwabe, Satdarshan P. Monga, Matthias Evert, Liling Tang, Diego F. Calvisi, Xin Chen
Publikováno v:
Gastroenterology. 163:481-494
YES-associated protein (YAP) aberrant activation is implicated in intrahepatic cholangiocarcinoma (iCCA). Transcriptional enhanced associate domain (TEAD)-mediated transcriptional regulation is the primary signaling event downstream of YAP. The role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c634e8906c6636af159cb8d2e3042006
https://doi.org/10.1053/j.gastro.2022.04.028
https://doi.org/10.1053/j.gastro.2022.04.028
The gene transcription patterns are regulated in response to extracellular stimuli and intracellular development programs. Recent studies have shown that chromatin dynamics which include nucleosome dynamics and histone modification play a crucial rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f60afe98c7c86c7a26bdd3073eab63
https://mts.intechopen.com/articles/show/title/chromatin-dynamics-chromatin-remodeler-epigenetic-modification-and-diseases
https://mts.intechopen.com/articles/show/title/chromatin-dynamics-chromatin-remodeler-epigenetic-modification-and-diseases
Autor:
Xin Chen, Yi Zhou, Guofei Cui, Hongwei Xu, Joanne Chu, Zheng Zhang, Lihui Yang, Jingxiao Wang, Diego F Calvisi, Shumei Lin, Haichuan Wang
Hepatocellular carcinoma (HCC) is a deadly malignancy with high genetic heterogeneity. TP53 loss of function (LOF) mutation and c-MET activation are frequent events in human HCCs. Here, we discovered that the simultaneous LOF mutations in TP53 and ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9834dc1d4e26dfb6935ea93045674c44
https://doi.org/10.21203/rs.3.rs-2176178/v1
https://doi.org/10.21203/rs.3.rs-2176178/v1