Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Guochao Liao"'
Autor:
Deying Yang, Xiang Luo, Qinghai Lian, Lingqiang Gao, Chengxin Wang, Xiaoxiao Qi, Rong Zhang, Zhongqiu Liu, Guochao Liao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 12, Pp 4432-4445 (2022)
We present a new strategy for self-adjuvanting vaccine development that has different types of covalently-linked immunostimulants as the carrier molecule. Using Tn antigen as the model, a three-component vaccine (MPLA-Tn-KRN7000) containing the TLR4
Externí odkaz:
https://doaj.org/article/93593e55c5294b18a89dff7f5eef1f7f
Autor:
Guochao Liao, Hungyan Lau, Zhongqiu Liu, Chinyu Li, Zeping Xu, Xiaoxiao Qi, Yu Zhang, Qian Feng, Runze Li, Xinyu Deng, Yebo Li, Qing Zhu, Sisi Zhu, Hua Zhou, Hudan Pan, Xingxing Fan, Yongchao Li, Dan Li, Liqing Chen, Bixia Ke, Zhe Cong, Qi Lv, Jiangning Liu, Dan Liang, An’an Li, Wenshan Hong, Linlin Bao, Feng Zhou, Hongbin Gao, Shi Liang, Bihong Huang, Miaoli Wu, Chuan Qin, Changwen Ke, Liang Liu
Publikováno v:
Virology Journal, Vol 19, Iss 1, Pp 1-11 (2022)
Abstracts The COVID-19 pandemic, caused by the SARS-CoV-2 virus and its variants, has posed unprecedented challenges worldwide. Existing vaccines have limited effectiveness against SARS-CoV-2 variants. Therefore, novel vaccines to match mutated viral
Externí odkaz:
https://doaj.org/article/b5dfb36d392846fbb42f5a05a7afc528
Publikováno v:
Molecules, Vol 28, Iss 15, p 5634 (2023)
SARS-CoV-2 is a highly contagious and pathogenic virus that first appeared in late December 2019 and caused a global pandemic in a short period. The virus is a single-stranded RNA virus belonging to the Coronaviridae family. Numerous treatments have
Externí odkaz:
https://doaj.org/article/b168fcdb8adc4165ac61a61d0d776fe1
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 621-631 (2021)
Natural products generally fall into the biologically relevant chemical space and always possess novel biological activities, thus making them a rich source of lead compounds for new drug discovery. With the recent technological advances, natural pro
Externí odkaz:
https://doaj.org/article/40fbba8dda3240bcbf43f3a24dc2696a
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 7, Pp 1253-1278 (2020)
Blocking the MDM2/X–P53 protein–protein interaction has been widely recognized as an attractive therapeutic strategy for the treatment of cancers. Numerous small-molecule MDM2 inhibitors have been reported since the release of the structure of th
Externí odkaz:
https://doaj.org/article/6c326b9530b741f5bc73ef0a79a7748e
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-14 (2019)
Abstract Histone demethylase LSD1 plays key roles during carcinogenesis, targeting LSD1 is becoming an emerging option for the treatment of cancers. Numerous LSD1 inhibitors have been reported to date, some of them such as TCP, ORY-1001, GSK-2879552,
Externí odkaz:
https://doaj.org/article/f7bb234c71cf477386bf08585d50a990
Autor:
Liqing Chen, Xiaoxiao Qi, Dan Liang, Guiqi Li, Xiaofang Peng, Xiaohui Li, Bixia Ke, Huanying Zheng, Zhongqiu Liu, Changwen Ke, Guochao Liao, Liang Liu, Qian Feng
Publikováno v:
Vaccines, Vol 10, Iss 9, p 1502 (2022)
The coronavirus disease-19 (COVID-19) pandemic has been ongoing since December 2019, with more than 6.3 million deaths reported globally as of August 2022. Despite the success of several SARS-CoV-2 vaccines, the rise in variants, some of which are re
Externí odkaz:
https://doaj.org/article/948bd48723fc4a6abcaa59e2205fcfb8
Publikováno v:
ACS Central Science, Vol 2, Iss 4, Pp 210-218 (2016)
Externí odkaz:
https://doaj.org/article/bca5dd59e1ca465389aef92da23a6c2b
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
As a new carbon-based nanomaterial, graphene has exhibited unique advantages in significantly improving the combination properties of traditional polymer hydrogels. The specific properties of graphene, such as high electrical conductivity, high therm
Externí odkaz:
https://doaj.org/article/d47dc37d6ae74cd7a6092913dc451aad
Autor:
Xiaoxu Qiao, Mengying Ji, Yunda Yao, Leilei Ma, Jinjun Wu, Guochao Liao, Hua Zhou, Zhongqiu Liu, Peng Wu
Publikováno v:
Molecules, Vol 23, Iss 6, p 1426 (2018)
Seven new triterpenoid saponins (1–7), together with three known ones (8–10), were isolated from Ilex pubescens. Elucidation of their structures was performed based on high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS), infrare
Externí odkaz:
https://doaj.org/article/458d4c60e2a745f9a6f019228c283d61