Výsledky vyhledávání

Transdermal patches for D-threo-methylphenidate (free base): Formulation aspects and in vivo pharmacokinetics

Autor: Huafei Luo, Yubo Wu, Furong Zhang, Guobei Lin, Chenghao Zhang, Zhuangzhi Zhu, Junyun Zhang, Jing Luo, Hao Wang

Publikováno v: Journal of Drug Delivery Science and Technology. 35:50-57

This study was designed to develop a drug-in-adhesive (DIA) type transdermal drug delivery system (TDDS) for D-threo-methylphenidate (D-threo-MP) that could be further developed for treating Attention-Deficit/Hyperactivity Disorder (ADHD) in children

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::323757c85b8e873cbd2c24d8e4937b76
https://doi.org/10.1016/j.jddst.2016.05.002

Zobrazit plný text záznamu

Quantitative Determination of Myricetin in Rat Plasma by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry and its Absolute Bioavailability

Autor: Jingze Duan, G. Li, Guobei Lin, Yang Dang, Yan Xie, Guang Ji, Ping Ma

Publikováno v: Drug Research. 64:516-522

Myricetin is a widely distributed bioactive flavonoid with scientific interest attributed to its anti-oxidant, antitumor, and anti-inflammatory properties. A specific and sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5087bfd4c0f052a33f35753169d2bcc
https://doi.org/10.1055/s-0033-1363220

Zobrazit plný text záznamu

Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma and its application to pharmacokinetic study

Autor: Yubo Wu, Junyun Zhang, Guobei Lin, Chenghao Zhang, Huafei Luo, Furong Zhang, Hao Wang

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1011

A chiral UFLC-MS/MS method was established and validated for quantifying d-threo-methylphenidate (d-threo-MPH), l-threo-methylphenidate (l-threo-MPH), d-threo-ethylphenidate (d-threo-EPH), l-threo-ethylphenidate (l-threo-EPH) and d,l-threo-ritalinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5434596e09e6197bddddca0846d988
https://pubmed.ncbi.nlm.nih.gov/26751592

Zobrazit plný text záznamu

Effects of stabilizing agents on the development of myricetin nanosuspension and its characterization: an in vitro and in vivo evaluation

Autor: Chao Hong, Guang Ji, Hongyi Shen, Yashu Yao, Yang Dang, Yan Xie, Guobei Lin, Guowen Li

Publikováno v: International journal of pharmaceutics. 477(1-2)

Although myricetin has various pharmacological applications, it shows low oral bioavailability (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e887bdbd871fdf7a28dbf43b5fedbb2
https://pubmed.ncbi.nlm.nih.gov/25445518

Zobrazit plný text záznamu

Preformulation studies of myricetin: a natural antioxidant flavonoid

Autor: Yashu, Yao, Guobei, Lin, Yan, Xie, Ping, Ma, Guowen, Li, Qianchao, Meng, Tao, Wu

Publikováno v: Die Pharmazie. 69(1)

Myricetin is a natural flavonoid which has attracted great interest due to its antioxidant and free-radical scavenging activities. Unfortunately, physicochemical properties of myricetin are largely unknown so far and this would impair the design and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e23639488814c532c24954da346c4324
https://pubmed.ncbi.nlm.nih.gov/24601218

Zobrazit plný text záznamu

Effects of solid dispersion and self-emulsifying formulations on the solubility, dissolution, permeability and pharmacokinetics of isorhamnetin, quercetin and kaempferol in total flavones of Hippophae rhamnoides L

Autor: Xiurong Yuan, Huilin Luo, Guoying Zhao, Guowen Li, Yan Xie, Jingze Duan, Guobei Lin

Publikováno v: Drug development and industrial pharmacy. 39(7)

The aim of this study was to investigate the effects of solid dispersions (SD) and self-emulsifying (SE) formulations on the solubility and absorption properties of active components in total flavones of Hippophae rhamnoides L. (TFH). The solubility,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d2435435fe767c869e52690a712362
https://pubmed.ncbi.nlm.nih.gov/22757776

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání