Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Guo-gang Xing"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-31 (2024)
Abstract Bone cancer pain (BCP) represents a prevalent symptom among cancer patients with bone metastases, yet its underlying mechanisms remain elusive. This study investigated the transcriptional regulation mechanism of Kv7(KCNQ)/M potassium channel
Externí odkaz:
https://doaj.org/article/86cac846465f4ff0a6ecb161acf7ae22
Autor:
Fan Xu, Xian-wei Zou, Li-qiong Yang, Shi-cong Mo, Quan-hao Guo, Jing Zhang, Xiechuan Weng, Guo-gang Xing
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
PurposeParkinson's disease (PD) is a serious neurodegenerative disease affecting the elderly. In general, the locomotion deficit, which seriously affects the daily life of patients with PD, usually occurs at a later stage. The mask face symptom meanw
Externí odkaz:
https://doaj.org/article/e3972adbb640488ebe769cfdf6551d07
Autor:
Zhu-Lin Yuan, Xiao-Dan Liu, Zi-Xian Zhang, Song Li, Yue Tian, Ke Xi, Jie Cai, Xiao-Mei Yang, Min Liu, Guo-Gang Xing
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104936- (2022)
Summary: Bone cancer pain is a common symptom in cancer patients with bone metastases and its underlying mechanisms remain unknown. Here, we report that Runx1 directly upregulates the transcriptional activity of P2X3 receptor (P2X3R) gene promoter in
Externí odkaz:
https://doaj.org/article/a28b4d8be908449782d28c8e027809e9
Autor:
Xiao-Yu Chen, Dan-Yu Song, Li Jiang, Dan-Dan Tan, Yi-Dan Liu, Jie-Yu Liu, Xing-Zhi Chang, Guo-Gang Xing, Tatsushi Toda, Hui Xiong
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
ObjectiveAlpha-dystroglycanopathy (α-DGP) is a subtype of muscular dystrophy caused by defects in the posttranslational glycosylation of α-dystroglycan (α-DG). Our study aimed to summarize the clinical and genetic features of POMT2-related α-DGP
Externí odkaz:
https://doaj.org/article/86eaa752ab9d45f5a00cfd625336073e
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6524 (2020)
Neuropathic pain is more complex and severely affects the quality of patients’ life. However, the therapeutic strategy for neuropathic pain in the clinic is still limited. Previously we have reported that electroacupuncture (EA) has an attenuating
Externí odkaz:
https://doaj.org/article/13aefb193092475aa564e161f865595f
Publikováno v:
Neural Plasticity, Vol 2018 (2018)
Mechanisms underlying remifentanil- (RF-) induced hyperalgesia, a phenomenon that is generally named as opioid-induced hyperalgesia (OIH), still remain elusive. The ventral posterior lateral nucleus (VPL) of the thalamus, a key relay station for the
Externí odkaz:
https://doaj.org/article/23de4e6ac20d41518d2c9281317a51a5
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 428-451 (2015)
The pathogenic mechanisms underlying neuropathic pain still remain largely unknown. In this study, we investigated whether spinal BDNF contributes to dorsal horn LTP induction and neuropathic pain development by activation of GluN2B-NMDA receptors vi
Externí odkaz:
https://doaj.org/article/3d10f931e3aa4701964d136a2d059b4d
Publikováno v:
Pain Research and Management, Vol 19, Iss 4, Pp 205-211 (2014)
BACKGROUND: Pregabalin (PGB) is a novel antiepileptic drug and is also used as a first-line medication for the treatment of neuropathic pain. However, the mechanisms of its analgesic effects remain largely unknown.
Externí odkaz:
https://doaj.org/article/fac828257e9a461d9d24d9596b4080ff
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114623 (2014)
We have previously reported that enhanced excitability of dorsal root ganglia (DRG) neurons contributes to the development of bone cancer pain, which severely decreases the quality of life of cancer patients. Nav1.8, a tetrodotoxin-resistant (TTX-R)
Externí odkaz:
https://doaj.org/article/dce90b8c7359477b8a97582807f414a7
Autor:
Ke Xi, Si-Qing Cai, Hui-Fang Yan, Yue Tian, Jie Cai, Xiao-Mei Yang, Jing-Min Wang, Guo-Gang Xing
Publikováno v:
The Journal of Neuroscience. 43:3949-3969
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with highly heritable heterogeneity. Mutations of CUB and sushi multiple domains 3 (CSMD3) gene have been reported in individuals with ASD. However, the underlying mechanisms of CSMD3 fo