Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Guo-Liang Chew"'
Autor:
Guo-Liang Chew, Marie Bleakley, Robert K. Bradley, Harmit S. Malik, Steven Henikoff, Antoine Molaro, Jay Sarthy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Short H2A variants are testis-specific histones that destabilize nucleosomes during spermatogenesis. In this study, the authors show that these variants are expressed in an array of different cancers and identify splicing changes associated with nucl
Externí odkaz:
https://doaj.org/article/53d7c5a963ab49e9ab627725b16041d3
Autor:
Takako I. Jones, Guo-Liang Chew, Pamela Barraza-Flores, Spencer Schreier, Monique Ramirez, Ryan D. Wuebbles, Dean J. Burkin, Robert K. Bradley, Peter L. Jones
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-28 (2020)
Abstract Background All types of facioscapulohumeral muscular dystrophy (FSHD) are caused by the aberrant activation of the somatically silent DUX4 gene, the expression of which initiates a cascade of cellular events ultimately leading to FSHD pathop
Externí odkaz:
https://doaj.org/article/812ce4b6ddbc49389bddf06254db2254
Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-24 (2019)
Abstract Background General translational cis-elements are present in the mRNAs of all genes and affect the recruitment, assembly, and progress of preinitiation complexes and the ribosome under many physiological states. These elements include mRNA f
Externí odkaz:
https://doaj.org/article/ba25854501254616847d767a6ffc5f25
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Upstream open reading frames (uORFs) can repress gene expression. Here, Guo-Liang Chew and colleagues use bioinformatics approaches to show that conservation of uORF-mediated translational repression is mediated by sequence features in human, mouse a
Externí odkaz:
https://doaj.org/article/2cc05969e6f84064a5e5c7b84f3be8e5
Autor:
Sebastian Maurer-Stroh, Ashar Malik, Dimitar Kenanov, Cheng-Shoong Chong, Mert Burak Ozturk, Maxime Hebrard, Ying Swan Ho, Zhenxun Wang, Vachiranee Limviphuvadh, Jhoann Miyajima, Roberto Magallanes, Xueling Sim, Jin Fang Chai, Sonia Davila, Khung Keong Yeo, Khai Pang Leong, Liuh Ling Goh, Neerja Karnani, Johan Gunnar Eriksson, Ching-Yu Cheng, Tien Wong, Marie Loh, Rinkoo Dalan, Chiea Chuen Khor, Guo-Liang Chew, Weng Khong Lim, Joanne Ngeow, John Chambers, E Shyong Tai, Nicolas Bertin, Chris Soon Heng Tan, Judice Koh, Patrick Tan, Chandra Verma
One of the promises of precision medicine is to understand and act on inter-individual genetic differences in drug responses. SNPdrug3D contains the complete genomic landscape of missense single nucleotide variants (SNV) across the human proteome and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dea066a53ae7a448d8ac2483b836a175
https://doi.org/10.21203/rs.3.rs-2377190/v1
https://doi.org/10.21203/rs.3.rs-2377190/v1
Autor:
Benjamin H. Durham, Yasutaka Hayashi, Frank McCormick, Sanjoy Mehta, Atsushi Tanaka, Hiromi Yamazaki, Ettaib El Marabti, Chie Fukui, Ralph Garippa, Bo Liu, Guo-Liang Chew, Sydney X. Lu, Jacob T. Polaski, Alex Penson, Justin Taylor, Eric Wang, Sisi Chen, Daichi Inoue, Simon J. Hogg, Daniel Zakheim, Caroline Erickson, Jose Mario Bello Pineda, Miki Fukumoto, Pau Castel, Omar Abdel-Wahab, Susumu Kobayashi, Katherine Knorr, Robert K. Bradley
Publikováno v:
Nature genetics, vol 53, iss 5
Nature genetics
Nature genetics
Most eukaryotes harbor two distinct pre-mRNA splicing machineries: the major spliceosome, which removes >99% of introns, and the minor spliceosome, which removes rare, evolutionarily conserved introns. Although hypothesized to serve important regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977cfa901744455e3cb0d97f4b8e8476
https://doi.org/10.1038/s41588-021-00828-9
https://doi.org/10.1038/s41588-021-00828-9
Autor:
Sydney X. Lu, Yu Chen, Daichi Inoue, Justin Taylor, Ariele Block, Robert K. Bradley, Cigall Kadoch, Alex Penson, Andrew R. D’Avino, Khrystyna North, Bo Liu, Brittany C. Michel, Hana Cho, Tyler D. Hitchman, Guo-Liang Chew, Stanley Chun-Wei Lee, Akihide Yoshimi, Joseph Pangallo, Luisa F. Escobar-Hoyos, Omar Abdel-Wahab, Lillian Bitner, Amanda R. Moore
Publikováno v:
Nature
SF3B1 is the most commonly mutated RNA splicing factor in cancer1–4, but the mechanisms by which SF3B1 mutations promote malignancy are poorly understood. Here we integrated pan-cancer splicing analyses with a positive-enrichment CRISPR screen to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bde0c889ae3314a95089ebca3406ace
http://europepmc.org/articles/PMC6858563
http://europepmc.org/articles/PMC6858563
Autor:
Sydney X. Lu, Robert K. Bradley, Jose Mario Bello Pineda, Justin Taylor, Frank McCormick, Ralph Garippa, Yasutaka Hayashi, Sanjoy Mehta, Benjamin H. Durham, Ettaib El Marabti, Miki Fukumoto, Jacob T. Polaski, Alexander V Penson, Daniel Zakheim, Sisi Chen, Caroline Erickson, Guo-Liang Chew, Simon J. Hogg, Pau Castel, Bo Liu, Hiromi Yamazaki, Omar Abdel-Wahab, Daichi Inoue, Chie Fukui, Susumu Kobayashi
Publikováno v:
Blood. 136:10-11
Mutations in RNA splicing factors are amongst the most common genetic alterations in myeloid malignancies. Mutations in the splicing factors SF3B1, SRSF2, and U2AF1 occur as heterozygous, missense mutations and have been shown to confer a change-of-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3da7fcf1eaa2802d5f9fb329a0bd6331
https://doi.org/10.1182/blood-2020-136445
https://doi.org/10.1182/blood-2020-136445
Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes
Publikováno v:
Genome Biology
Genome biology, vol 20, iss 1
Genome Biology, Vol 20, Iss 1, Pp 1-24 (2019)
Genome biology, vol 20, iss 1
Genome Biology, Vol 20, Iss 1, Pp 1-24 (2019)
BACKGROUNDGeneral translationalcis-elements are present in the mRNAs of all genes and affect the recruitment, assembly, and progress of preinitiation complexes and the ribosome under many physiological states. These elements are: mRNA folding, upstre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11358e230e5810ccaf2ea6bee66502f7
https://doi.org/10.1186/s13059-019-1761-9
https://doi.org/10.1186/s13059-019-1761-9
Publikováno v:
Molecular cell. 70(3)
Summary The stability of mRNAs is regulated by signals within their sequences, but a systematic and predictive understanding of the underlying sequence rules remains elusive. Here we introduce UTR-seq, a combination of massively parallel reporter ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec7bccd8341fc540d1fc486547c3717
https://pubmed.ncbi.nlm.nih.gov/29225039
https://pubmed.ncbi.nlm.nih.gov/29225039