Výsledky vyhledávání - "Guo-Kai Shang"

Akademický článek

Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation

Autor: Sen‐bo Yan, Huan Liang, Peng Zhan, Hui Zheng, Qin‐xiao Zhao, Zi‐jie Zheng, Hui‐xia Lu, Guo‐kai Shang, Xiao‐ping Ji

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 6, Pp 2623-2641 (2023)

Abstract Background Declined skeletal muscle mass and function are inevitable consequences of long‐term diabetes and bring about many adverse events. Muscle fibre atrophy and interstitial fibrosis are major pathological manifestations of diabetic s

Externí odkaz: https://doaj.org/article/34db39bd243748afb87dd60d4b038350

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Akademický článek

Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα+ mesenchymal progenitors

Autor: Guo‐kai Shang, Lu Han, Zhi‐hao Wang, Ming Song, Di Wang, Yan‐min Tan, Yi‐hui Li, Yu‐lin Li, Wei Zhang, Ming Zhong

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1741-1756 (2021)

Abstract Background Sarcopenia widely exists in elderly people and triggers numerous age‐related events. The essential pathologic change lies in the increased intramuscular adipose tissue after aging with no exception to non‐obese objects. Pim1 a

Externí odkaz: https://doaj.org/article/a5e9e5cad6de403c8051d6d431c0652e

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Akademický článek

Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles

Autor: Guo‐Kai Shang, Lu Han, Zhi‐Hao Wang, Ya‐Peng Liu, Sen‐Bo Yan, Wen‐Wen Sai, Di Wang, Yi‐Hui Li, Wei Zhang, Ming Zhong

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 4, Pp 1104-1120 (2020)

Abstract Background Sarcopenia causes several adverse events in elderly people. Muscle fibre atrophy and interstitial fibrosis are the main histopathological changes in sarcopenia and account for decreased muscle function. Tribbles homologue 3 (TRB3)

Externí odkaz: https://doaj.org/article/08db9debcc474069a576334d59b5af8f

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Akademický článek

Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle

Autor: Di Wang, Ming Song, Long-fei Shen, Lu Han, Ping Zhu, Xu Jia, Guo-kai Shang, Yuan Cao, Wei Zhang, Ming Zhong, Zhi-hao Wang

Publikováno v: Frontiers in Physiology, Vol 12 (2022)

BackgroundPatients suffering from chronic heart failure (CHF) show an increased prevalence of sarcopenia. Levosimendan is an effective drug for the treatment of heart failure, but its effect on sarcopenia is still unclear. We aimed to explore whether

Externí odkaz: https://doaj.org/article/e5fc78e0012240ccbdf531dde65cbd64

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Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα + mesenchymal progenitors

Autor: Ming Song, Guo-Kai Shang, Wei Zhang, Ming Zhong, Yulin Li, Yi-Hui Li, Lu Han, Zhi-Hao Wang, Yan-Min Tan, Di Wang

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1741-1756 (2021)

Background Sarcopenia widely exists in elderly people and triggers numerous age‐related events. The essential pathologic change lies in the increased intramuscular adipose tissue after aging with no exception to non‐obese objects. Pim1 appears to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ac057fd80d9ed387b5b08b1c5ad4df
https://doi.org/10.1002/jcsm.12770

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Urinary exosomal CD26 is associated with recovery from acute kidney injury in intensive care units: a prospective cohort study

Autor: Guo-Kai Shang, Xiaomei Chen, Hui-Min Zhou, Qiang Sun, Fang-Fang Chen, Wei Zhang, Ming Zhong, Yi-Hui Li, Hao Wang, Chen Li, Dawei Wu, Juan Du, Shifang Ding, Zhi-Hao Wang, Feng Wang, Yirui Liu

Publikováno v: Clinical Chemistry and Laboratory Medicine (CCLM). 59:1535-1546

Objectives Currently there is no validated method to predict renal reversal and recovery after acute kidney injury (AKI). As exosomes have the potential for AKI prognosis and CD26 is involved in the mechanisms in AKI, this study aims to investigate w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2e4684cb8bf0876fc6129eac8147de
https://doi.org/10.1515/cclm-2021-0040

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Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles

Autor: Lu Han, Wei Zhang, Yi-Hui Li, Ya-Peng Liu, Zhi-Hao Wang, Ming Zhong, Di Wang, Guo-Kai Shang, Sen-bo Yan, Wen-Wen Sai

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 4, Pp 1104-1120 (2020)

Background Sarcopenia causes several adverse events in elderly people. Muscle fibre atrophy and interstitial fibrosis are the main histopathological changes in sarcopenia and account for decreased muscle function. Tribbles homologue 3 (TRB3) was prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae7d9c8cbc9122812595e368c8cff23
http://europepmc.org/articles/PMC7432570

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Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle

Autor: Di Wang, Ming Song, Long-fei Shen, Lu Han, Ping Zhu, Xu Jia, Guo-kai Shang, Yuan Cao, Wei Zhang, Ming Zhong, Zhi-hao Wang

Publikováno v: Frontiers in Physiology
Frontiers in Physiology, Vol 12 (2022)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad35ab6675afe1db48f7e2a68622ebf2
https://pubmed.ncbi.nlm.nih.gov/35126176

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Exercise Capacity is Improved by Levosimendan in Heart Failure and Sarcopenia Mice via the Alleviation of Atrophy and Apoptosis of Skeletal Muscle

Autor: Wei Zhang, Di Wang, Zhi-Hao Wang, Ming Song, Xu Jia, Ping Zhu, Ming Zhong, Yuan Cao, Lu Han, Long-fei Shen, Guo-Kai Shang

Background Sarcopenia, a common complication of heart failure (HF), dramatically reduces the benefits of exercise training. Levosimendan is an effective drug for the treatment of heart failure, but its relationship with sarcopenia is still unclear. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c20256dd76378fa7aa6935229d63ed6f
https://doi.org/10.21203/rs.3.rs-617003/v1

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PTPN2 improved renal injury and fibrosis by suppressing STAT‐induced inflammation in early diabetic nephropathy

Autor: Fang-Fang Chen, Wei Zhang, Ming Song, Ming Zhong, Lu Han, Guo-Kai Shang, Ya Li, Zhi-Hao Wang, Di Wang, Yulin Li, Hui-Min Zhou

Publikováno v: Journal of Cellular and Molecular Medicine

Diabetic nephropathy (DN) is a chronic inflammatory disease triggered by disordered metabolism. Recent studies suggested that protein tyrosine phosphatase non‐receptor type 2 (PTPN2) could ameliorate metabolic disorders and suppress inflammatory re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cd9eb5acd82d50d91ec0916c716108
http://europepmc.org/articles/PMC6533506

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