Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Guo-Jun Liu"'
Autor:
Léa El Chemali, Suzan Boutary, Song Liu, Guo-Jun Liu, Ryan J. Middleton, Richard B. Banati, Gregor Bahrenberg, Rainer Rupprecht, Michael Schumacher, Liliane Massaad-Massade
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7327 (2024)
GRT-X, which targets both the mitochondrial translocator protein (TSPO) and the Kv7.2/3 (KCNQ2/3) potassium channels, has been shown to efficiently promote recovery from cervical spine injury. In the present work, we investigate the role of GRT-X and
Externí odkaz:
https://doaj.org/article/7b57cc2571614bca8e64404399438ea4
Autor:
Philippe Liere, Guo-Jun Liu, Antoine Pianos, Ryan J. Middleton, Richard B. Banati, Yvette Akwa
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2474 (2023)
The 18 kDa translocator protein (TSPO/PBR) is a multifunctional evolutionary highly conserved outer mitochondrial membrane protein. Decades of research has reported an obligatory role of TSPO/PBR in both mitochondrial cholesterol transport and, thus,
Externí odkaz:
https://doaj.org/article/77c9ec88cd5e4aaa8b4a0c3a39a670f2
Mitochondrial Translocator Protein (TSPO) Expression in the Brain After Whole Body Gamma Irradiation
Autor:
Calina Betlazar, Ryan J. Middleton, Nicholas Howell, Ben Storer, Emma Davis, Justin Davies, Richard Banati, Guo-Jun Liu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The brain’s early response to low dose ionizing radiation, as may be encountered during diagnostic procedures and space exploration, is not yet fully characterized. In the brain parenchyma, the mitochondrial translocator protein (TSPO) is constitut
Externí odkaz:
https://doaj.org/article/0ad406ec46a141e0b7981955bc80196d
Microgravity × Radiation: A Space Mechanobiology Approach Toward Cardiovascular Function and Disease
Autor:
Carin Basirun, Melanie L. Ferlazzo, Nicholas R. Howell, Guo-Jun Liu, Ryan J. Middleton, Boris Martinac, S. Anand Narayanan, Kate Poole, Carmine Gentile, Joshua Chou
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
In recent years, there has been an increasing interest in space exploration, supported by the accelerated technological advancements in the field. This has led to a new potential environment that humans could be exposed to in the very near future, an
Externí odkaz:
https://doaj.org/article/f893624aaca74ed892204eb65b9969e9
Publikováno v:
Metals, Vol 11, Iss 10, p 1648 (2021)
The effects of small amounts of Ce-rich misch metal (Mm: 0.5, 1.0 and 2.0 wt.%) addition on the microstructure and tensile properties of as-cast Mg-7Al-3Sn-1Zn wt.% (ATZ731) alloy have been investigated. The addition of Mm restricts the formation of
Externí odkaz:
https://doaj.org/article/94d251d92da543ffb0ac08ccdbb7ed8a
Publikováno v:
Cells, Vol 10, Iss 9, p 2381 (2021)
Microglia, the innate immune cells of the central nervous system, play a pivotal role in the modulation of neuroinflammation. Neuroinflammation has been implicated in many diseases of the CNS, including Alzheimer’s disease and Parkinson’s disease
Externí odkaz:
https://doaj.org/article/a22c9deca9ee43a6a353109e3e5af6b5
Publikováno v:
Redox Biology, Vol 9, Iss C, Pp 144-156 (2016)
Responses of the central nervous system (CNS) to stressors and injuries, such as ionising radiation, are modulated by the concomitant responses of the brains innate immune effector cells, microglia. Exposure to high doses of ionising radiation in bra
Externí odkaz:
https://doaj.org/article/98a94e0eb7ab49dda7d0a497e8de8db4
Publikováno v:
Cells, Vol 9, Iss 2, p 512 (2020)
The translocator protein (TSPO) is an outer mitochondrial membrane protein that is widely used as a biomarker of neuroinflammation, being markedly upregulated in activated microglia in a range of brain pathologies. Despite its extensive use as a targ
Externí odkaz:
https://doaj.org/article/497ee036de564548ba6c4ccb827083f8
Autor:
Fuyuan Zhang, Linyang Liu, Shengnan Ni, Jiankang Deng, Guo-Jun Liu, Ryan Middleton, David W. Inglis, Shuo Wang, Guozhen Liu
Publikováno v:
Nanomaterials, Vol 9, Iss 1, p 104 (2019)
In order to satisfy the need for sensitive detection of Aflatoxin M1 (AFM1), we constructed a simple and signal-on fluorescence aptasensor based on an autocatalytic Exonuclease III (Exo III)-assisted signal amplification strategy. In this sensor, the
Externí odkaz:
https://doaj.org/article/cfac1123597143fdbd8b1489d519a68a
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2707 (2018)
The inducible expression of the mitochondrial translocator protein 18 kDa (TSPO) by activated microglia is a prominent, regular feature of acute and chronic-progressive brain pathology. This expression is also the rationale for the continual developm
Externí odkaz:
https://doaj.org/article/1938f3939a564a3188951f0bae109ebb