Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Guo-Gang Tu"'
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 6, Pp o1381-o1381 (2010)
In the title compound, C14H16ClN3O2S, the dihedral angle between the 4-chlorophenyl and 1,3,4-oxadiazole rings is 67.1 (1)° and the orientation of the amide N—H and C=O bonds is anti. In the crystal, molecules are linked by N—H...O and N—H...S
Externí odkaz:
https://doaj.org/article/9f9577066ecc4299824ebfc850792ab0
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 4, Pp o765-o765 (2010)
In the structure of the title compound, C18H15ClN4O4S, the dihedral angle between the two benzene rings is 1.4 (3)°. The angle between the phenyl ring and thiadiazole ring is 5.8 (4)°. The conformations of the N—H and C=O bonds are anti with resp
Externí odkaz:
https://doaj.org/article/d6c42ed961bc423d95e97da4ff02ff3d
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 12, Pp o2983-o2983 (2009)
The asymmetric unit of the crystal structure of the title compound, C8H9ClN2O2, contains four independent molecules. The dihedral angles between the urea N—(C=O)—N planes and the benzene rings are 83.3 (3), 87.8 (1), 89.1 (1) and 17.5 (2)° in th
Externí odkaz:
https://doaj.org/article/676575e8ce1c4b189d08f90e6a239bb5
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 2, Pp o325-o325 (2009)
In the structure of the title compound, C17H13BrN4O2S, the dihedral angle between the two benzene rings is 38.5 (1)°; the angle between the 4-bromobenzene and thiadiazole rings is 1.3 (1)°. The conformations of the N—H and C=O bonds are anti with
Externí odkaz:
https://doaj.org/article/804b6cba8ea749ab866a7ad68c23a612
Publikováno v:
Acta Crystallographica Section E, Vol 64, Iss 10, Pp o1887-o1887 (2008)
The asymmetric unit of the title compound, C21H20N4O3S, contains two independent molecules. The dihedral angles between the two benzene rings are 47.6 (1) and 30.2 (1)°, the corresponding values between the p-methoxybenzene and thiadiazol rings are
Externí odkaz:
https://doaj.org/article/2fadb2b4fbb249989552dd2c4470e1cc
Publikováno v:
Acta Crystallographica Section E, Vol 64, Iss 10, Pp o2006-o2006 (2008)
In the title compound, C20H17ClN4O2S, the dihedral angle between the two benzene rings is 65.9 (1)°; the corresponding angle between the 4-chlorophenyl and thiadiazole rings is 3.4 (8)°. The conformations of the N—H and C=O bonds are anti with re
Externí odkaz:
https://doaj.org/article/814f4eb067f246b08662a32a6fa08b89
Publikováno v:
Current Computer-Aided Drug Design. 17:619-626
Background: The aminopeptidase N (APN) over-expressed in tumor cells plays a critical role in angiogenesis which makes the development of APN inhibitors an attractive strategy for cancer research. Aims and Objectives: It is clinically significant to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95600f79c468f1c5ad136ff5bbd13d2
https://doi.org/10.2174/1573409916666200703161039
https://doi.org/10.2174/1573409916666200703161039
Publikováno v:
Medicinal Chemistry Research. 28:498-504
Over the years QSAR methods have developed from 2D-QSAR to more complex 4D-QSAR which features freedom of alignment and conformational flexibility of individual ligands. This approach takes advantage of conformational ensemble profile (CEP) generated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2ba76fe55343f2c52d944b7136a6b7a
https://doi.org/10.1007/s00044-019-02303-x
https://doi.org/10.1007/s00044-019-02303-x
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 17(6)
Background: As a target for anticancer treatment, aminopeptidase N (APN) shows its overexpression on diverse malignant tumor cells and associates with cancer invasion, angiogenesis and metastasis. Objective: The objective of the study was the design,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44728adc9e90b4f91405cc5351208328
https://pubmed.ncbi.nlm.nih.gov/31880250
https://pubmed.ncbi.nlm.nih.gov/31880250
Publikováno v:
International Journal of Pharmacology. 11:920-928
A B S T R A C T The MIFs was applied to a data set of 40 N-phenylhomophthalimide derivatives of APN inhibitors to generate the 3D-QSAR model at various 3D grid spacing. The cross-validated correlation coefficient q 2 LMO (0.6204) and r 2 pred (0.9810
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c66a8a891e6e341709ea75b7b5d1317e
https://doi.org/10.3923/ijp.2015.920.928
https://doi.org/10.3923/ijp.2015.920.928