Zobrazeno 1 - 10
of 407
pro vyhledávání: '"Guo-Cheng Yuan"'
Autor:
Michal Polonsky, Louisa M. S. Gerhardt, Jina Yun, Kari Koppitch, Katsuya Lex Colón, Henry Amrhein, Barbara Wold, Shiwei Zheng, Guo-Cheng Yuan, Matt Thomson, Long Cai, Andrew P. McMahon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Kidney injury disrupts the intricate renal architecture and triggers limited regeneration, together with injury-invoked inflammation and fibrosis. Deciphering the molecular pathways and cellular interactions driving these processes is challe
Externí odkaz:
https://doaj.org/article/9b1f0d824f174096a06b6edc3a33acbc
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Multimodal integration combines information from different sources or modalities to gain a more comprehensive understanding of a phenomenon. The challenges in multi-omics data analysis lie in the complexity, high dimensionality, and heteroge
Externí odkaz:
https://doaj.org/article/1b1291cda47649f4a6da91973244af06
Autor:
Tianxin Liu, Qian Zhu, Yan Kai, Trevor Bingham, Stacy Wang, Hye Ji Cha, Stuti Mehta, Thorsten M. Schlaeger, Guo-Cheng Yuan, Stuart H. Orkin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Although emerging evidence indicates that alterations in proteins within nuclear compartments elicit changes in chromosomal architecture and differentiation, the underlying mechanisms are not well understood. Here we investigate the direct r
Externí odkaz:
https://doaj.org/article/23d68e42d7da4813946ed12c450bf64b
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background Chromosomal compartmentalization plays a critical role in maintaining proper transcriptional programs in cell differentiation and oncogenesis. However, currently the prevalent method for comparative analysis of compartmentalizatio
Externí odkaz:
https://doaj.org/article/0a4fbc55ec7449adb3256e79af851a7f
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Cell-cell interaction (CCI) plays a pivotal role in cellular communication within the tissue microenvironment. The recent development of spatial transcriptomics (ST) technology and associated data analysis methods has empowered researchers to systema
Externí odkaz:
https://doaj.org/article/c6a3bf75469e4bb79cf10a013f4b0b3d
Akademický článek
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Autor:
Minghui Wang, Won-min Song, Chen Ming, Qian Wang, Xianxiao Zhou, Peng Xu, Azra Krek, Yonejung Yoon, Lap Ho, Miranda E. Orr, Guo-Cheng Yuan, Bin Zhang
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-52 (2022)
Abstract Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic studies have revealed biomarkers, risk factors, pathways, and targets of
Externí odkaz:
https://doaj.org/article/52b84704eac1470fa2ea4882455766ed
Autor:
Peng Xu, Minghui Wang, Won-min Song, Qian Wang, Guo-Cheng Yuan, Peter H. Sudmant, Habil Zare, Zhidong Tu, Miranda E. Orr, Bin Zhang
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-20 (2022)
Abstract Background Cellular senescence is a complex stress response that impacts cellular function and organismal health. Multiple developmental and environmental factors, such as intrinsic cellular cues, radiation, oxidative stress, oncogenes, and
Externí odkaz:
https://doaj.org/article/9a664a69d00d4563a1ea3d13e961eb52
Autor:
Guyu Qin, Eun-Sil Park, Xueqing Chen, Sen Han, Dongxi Xiang, Fang Ren, Gang Liu, Huidong Chen, Guo-Cheng Yuan, Zhe Li
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105861- (2023)
Summary: Epithelial ovarian cancer (EOC) can originate from either fallopian tube epithelial (FTE) or ovarian surface epithelial (OSE) cells, but with different latencies and disease outcomes. To address the basis of these differences, we performed s
Externí odkaz:
https://doaj.org/article/16d6da11efd3423fbb9c534ad8403adf
Autor:
Hye Ji Cha, Özgün Uyan, Yan Kai, Tianxin Liu, Qian Zhu, Zuzana Tothova, Giovanni A. Botten, Jian Xu, Guo-Cheng Yuan, Job Dekker, Stuart H. Orkin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Interactions between chromatin and nuclear components and whether these interactions affect development is not well understood. Here the authors show inner nuclear protein Matrin-3 (Matr3) loss leads to accelerated erythroid maturation, and that Matr
Externí odkaz:
https://doaj.org/article/0375ca998e104d8ca0b29f84e0c5f8f6