Effect of intravitreal anti-vascular endothelial growth factor therapy on the risk of arterial thromboembolic events: a meta-analysis.

Autor: Jin-Wei Cheng, Shi-Wei Cheng, Guo-Cai Lu, Rui-Li Wei

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41325 (2012)

BackgroundIntravitreal anti-vascular endothelial growth factor (VEGF) monoclonal antibodies are used in ocular neovascular diseases. A consensus has emerged that intravenous anti-VEGF can increase the risk of arterial thromboembolic events. However,

Externí odkaz: https://doaj.org/article/749e069a68cd41bc9da7ac69440e23a1

Intraocular pressure-lowering effects of commonly used fixed-combination drugs with timolol: a systematic review and meta-analysis.

Autor: Jin-Wei Cheng, Shi-Wei Cheng, Lian-Di Gao, Guo-Cai Lu, Rui-Li Wei

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e45079 (2012)

BACKGROUND: The first goal of medical therapy in glaucoma is to reduce intraocular pressure (IOP), and the fixed-combination medications are needed to achieve sufficiently low target IOP. The aim of this systematic review and meta-analysis is to eval

Externí odkaz: https://doaj.org/article/4ecd184b6f2d4eb3aa6707fbe316a9e1

Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation

Autor: Guo-Cai Lu, Shijie Feng, Chen-Lin Yu, Jinwei Cheng, Ying Zong

Publikováno v: Cellular Physiology and Biochemistry, Vol 41, Iss 2, Pp 784-794 (2017)

Background/Aims: Activating transcription factor 4 (ATF4) is a member of the activating transcription factor family which regulates the expression of genes involved in amino acid metabolism, redox homeostasis and ER stress responses. ATF4 is also ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9513eb770bc56091e6883a419c6235
https://doi.org/10.1159/000458742

NLRP3 inflammasome activation mediates fatigue-like behaviors in mice via neuroinflammation

Autor: Huaiyu Yu, Ying Zong, Yan-Gang Liu, Jin-Feng Li, Yongchun Chen, Zhen-Na Xia, Ji-Kuai Chen, Zi-Teng Zhang, Jiangbo Zhu, Xiu-Juan Ma, Guo-Cai Lu

Publikováno v: Neuroscience. 358

Numerous experimental and clinical studies have suggested that the interaction between the immune system and the brain plays an important role in the pathophysiology of chronic fatigue syndrome (CFS). The NLRP3 inflammasome is an important part of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9797d9b89fb4d9713b5710823eb3e2f3
https://pubmed.ncbi.nlm.nih.gov/28684277

Subchronic Toxicities of HZ1006, a Hydroxamate-Based Histone Deacetylase Inhibitor, in Beagle Dogs and Sprague-Dawley Rats

Autor: Tianbao Zhang, Guo-Cai Lu, Xiaofang Zhang, Xiaodong Zhang, Bo-Jun Yuan, Lijun Ren

Publikováno v: International Journal of Environmental Research and Public Health; Volume 13; Issue 12; Pages: 1190
International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, Vol 13, Iss 12, p 1190 (2016)

Histone deacetylase inhibitors (HDACIs), such as vorinostat and panobinostat, have been shown to have active effects on many hematologic malignancies, including multiple myeloma and cutaneous T-cell lymphoma. Hydroxamate-based (Hb) HDACIs have very g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eeda5ced044e83526495fe1e80a00e5