Characterization of the Effects of Mesenchymal Stromal Cells on Mouse and Human Islet Function

Autor: Ahmed A. Arzouni, Andreia Vargas‐Seymour, Paramjeet K. Dhadda, Chloe L. Rackham, Guo‐Cai Huang, Pratik Choudhary, Aileen J. F. King, Peter M. Jones

Publikováno v: Stem Cells Translational Medicine, Vol 8, Iss 9, Pp 935-944 (2019)

Abstract Islet transplantation has the potential to cure type 1 diabetes, but current transplantation protocols are not optimal and there is extensive loss of islet β‐cell insulin secretory function during the immediate post‐transplantation peri

Externí odkaz: https://doaj.org/article/832864f4082d47ec8e7ec4256c169630

Lipid-induced glucose intolerance is driven by impaired glucose kinetics and insulin metabolism in healthy individuals

Autor: Domenico Tricò, Alessandro Mengozzi, Simona Baldi, Roberto Bizzotto, Oladapo Olaniru, Klaudia Toczyska, Guo Cai Huang, Marta Seghieri, Silvia Frascerra, Stephanie A. Amiel, Shanta Persaud, Peter Jones, Andrea Mari, Andrea Natali

Publikováno v: Tricò, D, Mengozzi, A, Baldi, S, Bizzotto, R, Olaniru, O, Toczyska, K, Huang, G C, Seghieri, M, Frascerra, S, Amiel, S A, Persaud, S, Jones, P, Mari, A & Natali, A 2022, ' Lipid-induced glucose intolerance is driven by impaired glucose kinetics and insulin metabolism in healthy individuals ', Metabolism, vol. 134, no. 155247, 155247 . https://doi.org/10.1016/j.metabol.2022.155247

Aims: Hypertriglyceridemia is associated with an increased risk of type 2 diabetes. We aimed to comprehensively examine the effects of hypertriglyceridemia on major glucose homeostatic mechanisms involved in diabetes progression.Methods: In this rand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a517a23ff4634a87b99e3cc1f197dc
https://kclpure.kcl.ac.uk/en/publications/1e5367f8-9c75-46b9-adc5-ba20257ff0bc

Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide

Autor: Domagoj Cikes, Patricio Atanes, Guo-Cai Huang, Shanta J. Persaud, Josef M. Penninger

Neuromedin B (NMB) is a member of the neuromedin family of neuropeptides with a high level of region-specific expression in the brain. Several GWAS studies on non-obese and obese patients suggested that polymorphisms in NMB predispose to obesity by a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8733d6fba1b95c9565e7e4b6c1a6ba0d
https://doi.org/10.1101/2021.10.21.465287

The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling

Autor: Inmaculada Ruz-Maldonado, Bo Liu, Guo Cai Huang, Patricio Atanes, Shanta J. Persaud, Pratik Choudhary, Attilio Pingitore

Publikováno v: Cellular and Molecular Life Sciences

Aims Endocannabinoids are lipid mediators involved in the regulation of glucose homeostasis. They interact with the canonical cannabinoid receptors CB1 and CB2, and it is now apparent that some cannabinoid receptor ligands are also agonists at GPR55.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa86071809fbf64f532111c8b3f8f3f
http://europepmc.org/articles/PMC7599183

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Autor: Israa Mohammed Al-Amily, Shanta J. Persaud, Albert Salehi, Bo Liu, Patricio Atanes, Ross Hawkes, Guo Cai Huang, Inmaculada Ruz-Maldonado, Stefan Amisten, Min Zhao

Publikováno v: Cellular and Molecular Life Sciences
Atanes, P, Ruz-Maldonado, I, Hawkes, R, Liu, B, Zhao, M, Huang, G C, Al-Amily, I M, Salehi, A, Amisten, S & Persaud, S J 2018, ' Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets ', Cellular and Molecular Life Sciences, vol. 75, no. 16, pp. 3039–3050 . https://doi.org/10.1007/s00018-018-2778-z

Introduction Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc2f3cde7d3da7c062cb2fc02cf9fdd
http://europepmc.org/articles/PMC6061145