Zobrazeno 1 - 10
of 444
pro vyhledávání: '"Guo‐li Ming"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Quiescence, a hallmark of adult neural stem cells (NSCs), is required for maintaining the NSC pool to support life-long continuous neurogenesis in the adult dentate gyrus (DG). Whether long-lasting epigenetic modifications maintain NSC quies
Externí odkaz:
https://doaj.org/article/435930ed30574a3ea0984c5cfe65ac47
Autor:
Dennisse Jimenez-Cyrus, Vijay S. Adusumilli, Max H. Stempel, Sandra Maday, Guo-li Ming, Hongjun Song, Allison M. Bond
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114339- (2024)
Summary: Quiescent adult neural stem cells (NSCs) in the mammalian brain arise from proliferating NSCs during development. Beyond acquisition of quiescence, an adult NSC hallmark, little is known about the process, milestones, and mechanisms underlyi
Externí odkaz:
https://doaj.org/article/6a92b5cbbac0406689f074d792746430
Autor:
David E. Reynolds, Yusha Sun, Xin Wang, Phoebe Vallapureddy, Jianhua Lim, Menghan Pan, Andres Fernandez Del Castillo, Jonathan C. T. Carlson, Mark A. Sellmyer, MacLean Nasrallah, Zev Binder, Donald M. O'Rourke, Guo‐li Ming, Hongjun Song, Jina Ko
Publikováno v:
Advanced Science, Vol 11, Iss 14, Pp n/a-n/a (2024)
Abstract Organoids are becoming increasingly relevant in biology and medicine for their physiological complexity and accuracy in modeling human disease. To fully assess their biological profile while preserving their spatial information, spatiotempor
Externí odkaz:
https://doaj.org/article/093e7cd71dd54bd4803abb680b06bcc0
Autor:
Xiaolin Lin, Wei Wang, Mingyi Yang, Nadirah Damseh, Mirta Mittelstedt Leal de Sousa, Fadi Jacob, Anna Lång, Elise Kristiansen, Marco Pannone, Miroslava Kissova, Runar Almaas, Anna Kuśnierczyk, Richard Siller, Maher Shahrour, Motee Al-Ashhab, Bassam Abu-Libdeh, Wannan Tang, Geir Slupphaug, Orly Elpeleg, Stig Ove Bøe, Lars Eide, Gareth J. Sullivan, Johanne Egge Rinholm, Hongjun Song, Guo-li Ming, Barbara van Loon, Simon Edvardson, Jing Ye, Magnar Bjørås
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-34 (2023)
Abstract Background Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular processes, including DNA damage response, antioxidant pathways, cell cycle
Externí odkaz:
https://doaj.org/article/7925429016d24d4aa5b0140f53c8102b
Autor:
Carolina Gracia-Diaz, Yijing Zhou, Qian Yang, Reza Maroofian, Paula Espana-Bonilla, Chul-Hwan Lee, Shuo Zhang, Natàlia Padilla, Raquel Fueyo, Elisa A. Waxman, Sunyimeng Lei, Garrett Otrimski, Dong Li, Sarah E. Sheppard, Paul Mark, Margaret H. Harr, Hakon Hakonarson, Lance Rodan, Adam Jackson, Pradeep Vasudevan, Corrina Powel, Shehla Mohammed, Sateesh Maddirevula, Hamad Alzaidan, Eissa A. Faqeih, Stephanie Efthymiou, Valentina Turchetti, Fatima Rahman, Shazia Maqbool, Vincenzo Salpietro, Shahnaz H. Ibrahim, Gabriella di Rosa, Henry Houlden, Maha Nasser Alharbi, Nouriya Abbas Al-Sannaa, Peter Bauer, Giovanni Zifarelli, Conchi Estaras, Anna C. E. Hurst, Michelle L. Thompson, Anna Chassevent, Constance L. Smith-Hicks, Xavier de la Cruz, Alexander M. Holtz, Houda Zghal Elloumi, M J Hajianpour, Claudine Rieubland, Dominique Braun, Siddharth Banka, Genomic England Research Consortium, Deborah L. French, Elizabeth A. Heller, Murielle Saade, Hongjun Song, Guo-li Ming, Fowzan S. Alkuraya, Pankaj B. Agrawal, Danny Reinberg, Elizabeth J. Bhoj, Marian A. Martínez-Balbás, Naiara Akizu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Genetic variants in chromatin regulators are frequently found in neurodevelopmental disorders, but their effect in disease etiology is rarely determined. Here, we uncover and functionally define pathogenic variants in the chromatin modifier
Externí odkaz:
https://doaj.org/article/78105606e072432f9749da08dbbd20b7
Autor:
Sung-Min Lee, Bonsang Koo, Clément Carré, André Fischer, Chuan He, Ajeet Kumar, Kathy Liu, Kate D. Meyer, Guo-li Ming, Junmin Peng, Jean-Yves Roignant, Erik Storkebaum, Shuying Sun, Davide De Pietri Tonelli, Yinsheng Wang, Yi-Lan Weng, Luigi Pulvirenti, Yanhong Shi, Ki-Jun Yoon, Hongjun Song
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplastici
Externí odkaz:
https://doaj.org/article/b324500bfd034a9b89490eedec6f532c
Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function
Autor:
Surjeet Mastwal, Xinjian Li, Rianne Stowell, Matthew Manion, Wenyu Zhang, Nam-Shik Kim, Ki-Jun Yoon, Hongjun Song, Guo-Li Ming, Kuan Hong Wang
Publikováno v:
eLife, Vol 12 (2023)
Dopamine system dysfunction is implicated in adolescent-onset neuropsychiatric disorders. Although psychosis symptoms can be alleviated by antipsychotics, cognitive symptoms remain unresponsive and novel paradigms investigating the circuit substrates
Externí odkaz:
https://doaj.org/article/b7a4f6c7002442f99a80d102ea65c327
Autor:
Dennis Jgamadze, Paul M. Harary, Mackenzie Castellanos, Rachel Blue, Hongjun Song, Guo-li Ming, H. Isaac Chen
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102470- (2023)
Summary: Human stem-cell-derived organoids represent a promising substrate for transplantation-based neural repair. Here, we describe a protocol for transplanting forebrain organoids into an injured adult rat visual cortex. This protocol includes sur
Externí odkaz:
https://doaj.org/article/7a793e48b4f046a09c62b1d5746e0d55
Autor:
Edward Z. Song, Xin Wang, Benjamin I. Philipson, Qian Zhang, Radhika Thokala, Logan Zhang, Charles-Antoine Assenmacher, Zev A. Binder, Guo-li Ming, Donald M. O’Rourke, Hongjun Song, Michael C. Milone
Publikováno v:
Molecular Therapy: Oncolytics, Vol 27, Iss , Pp 288-304 (2022)
Antigen heterogeneity that results in tumor antigenic escape is one of the major obstacles to successful chimeric antigen receptor (CAR) T cell therapies in solid tumors including glioblastoma multiforme (GBM). To address this issue and improve the e
Externí odkaz:
https://doaj.org/article/52ea338bdced4e4cb747e87c08377ff4
Autor:
Paul M. Harary, Dennis Jgamadze, Jaeha Kim, John A. Wolf, Hongjun Song, Guo-li Ming, D. Kacy Cullen, H. Isaac Chen
Publikováno v:
Brain Sciences, Vol 13, Iss 12, p 1654 (2023)
Neural transplantation represents a promising approach to repairing damaged brain circuitry. Cellular grafts have been shown to promote functional recovery through “bystander effects” and other indirect mechanisms. However, extensive brain lesion
Externí odkaz:
https://doaj.org/article/2c71871b2e8c457fb2e23b5d954218b3