Implications of the virus-encoded miRNA and host miRNA in the pathogenicity of SARS-CoV-2

Autor: Liu, Zhi, Wang, Jianwei, Xu, Yuyu, Guo, Mengchen, Mi, Kai, Xu, Rui, Pei, Yang, Zhang, Qiangkun, Luan, Xiaoting, Hu, Zhibin, Liu#, Xingyin

The outbreak of COVID-19 caused by SARS-CoV-2 has rapidly spread worldwide and has caused over 1,400,000 infections and 80,000 deaths. There are currently no drugs or vaccines with proven efficacy for its prevention and little knowledge was known abo

Externí odkaz: http://arxiv.org/abs/2004.04874

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SARS-CoV-2 encoded microRNAs are involved in the process of virus infection and host immune response.

Autor: Liu Z; State Key Laboratory of Reproductive Medicine, Center of Global Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.; Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Wang J; State Key Laboratory of Reproductive Medicine, Center of Global Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.; Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Ge Y; National Health Commission Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Diseases Control and Prevention, Nanjing, Jiangsu 210009, China., Xu Y; State Key Laboratory of Reproductive Medicine, Center of Global Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.; Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Guo M; State Key Laboratory of Reproductive Medicine, Center of Global Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.; Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Mi K; State Key Laboratory of Reproductive Medicine, Center of Global Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.; Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Xu R; State Key Laboratory of Reproductive Medicine, Center of Global Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.; Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Pei Y; State Key Laboratory of Reproductive Medicine, Center of Global Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.; Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Zhang Q; State Key Laboratory of Reproductive Medicine, Center of Global Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.; Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Luan X; State Key Laboratory of Reproductive Medicine, Center of Global Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.; Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Hu Z; State Key Laboratory of Reproductive Medicine, Center of Global Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China., Chi Y; National Health Commission Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Diseases Control and Prevention, Nanjing, Jiangsu 210009, China., Liu X; State Key Laboratory of Reproductive Medicine, Center of Global Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.; Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province, School of Basic Medical Science, Nanjing Medical University, Nanjing, Jiangsu 211166, China.; Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu 211166, China.

Publikováno v: Journal of biomedical research [J Biomed Res] 2021 Jan 29; Vol. 35 (3), pp. 216-227.