Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Guo, Deqi"'
Autor:
John E. Munroe, Q. May Wang, Mark Joseph Tebbe, Frantz Victor, Shu-Hui Chen, Robert B. Johnson, Guo Deqi, Beverly A. Heinz, Jason Eric Lamar, Joseph M. Colacino, John I. Glass, Yip Yvonne Yee Mai
Publikováno v:
Letters in Drug Design & Discovery. 2:118-123
Autor:
Q. May Wang, John I. Glass, Yip Yvonne Yee Mai, Frantz Victor, Shu-Hui Chen, Nathan Yumibe, Robert B. Johnson, Nancy June Snyder, Guo Deqi, Jason Eric Lamar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:257-261
With the aim of discovering potent and selective HCV protease inhibitors, we synthesized and evaluated a series of 1a based tetrapeptidyl ketoamides with additional modification(s) at P1′, P1, and P3 positions. As a result of this effort, we found
Autor:
Hsiu-Chiung Yang, Patrick C. May, Guo Deqi, Jingdan Hu, David E. Timm, James Densmore Copp, Mccarthy James R, Shu-Hui Chen, Bruce D. Gitter, James McGee, Jason Eric Lamar, Ana B. Bueno
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(1)
We describe herein the syntheses and evaluation of a series of C-termini pyridyl containing Phe*-Ala-based BACE inhibitors (5-19). In conjunction with four fixed residues at the P1 (Phe), P1 0 (Ala), P2 0 (Val), and P2 0 cap (Pyr.), rather detailed S
Autor:
Jason Eric Lamar, Jon A. Erickson, Todd J. Kohn, Mccarthy James R, Hsiu-Chiung Yang, Guo Deqi, Patrick C. May, Shu-Hui Chen, David E. Timm, Yip Yvonne Yee Mai, James McGee
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(1)
With the aim of reducing molecular weight and adjusting log D value of BACE inhibitors to more favorable range for BBB penetration and better bioavailability, we synthesized and evaluated several series of P3 cap modified BACE inhibitors obtained via
Autor:
Kumar, Virendra, Guo, Deqi, Marella, Michael, Cassel, Joel A., DeHaven, Robert N., Daubert, Jeffrey D., Mansson, Erik
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2008 18(12):3667-3671
Akademický článek
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Autor:
Kumar, Virendra, Guo, Deqi, Daubert, Jeffrey D., Cassel, Joel A., DeHaven, Robert N., Mansson, Erik, DeHaven-Hudkins, Diane L., Maycock, Alan L.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2005 15(5):1279-1282
Autor:
Kumar, Virendra *, Guo, Deqi, Cassel, Joel A., Daubert, Jeffrey D., DeHaven, Robert N., DeHaven-Hudkins, Diane L., Gauntner, Erin K., Gottshall, Susan L., Greiner, Susan L., Koblish, Michael, Little, Patrick J., Mansson, Erik, Maycock, Alan L.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2005 15(4):1091-1095
Autor:
Lamar, Jason, Hu, Jingdan, Bueno, Ana Belen, Yang, Hsiu-Chiung, Guo, Deqi, Copp, James D., McGee, James, Gitter, Bruce, Timm, David, May, Patrick, McCarthy, James, Chen, Shu-Hui
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2004 14(1):239-243