HIV-Specific CD8 ⁺ T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue.

Autor: Reuter MA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Del Rio Estrada PM; Departamento de Investigación en Enfermedades Infecciosas, INER, Mexico City, Mexico., Buggert M; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden., Petrovas C; Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA., Ferrando-Martinez S; Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA., Nguyen S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sada Japp A; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ablanedo-Terrazas Y; Departamento de Investigación en Enfermedades Infecciosas, INER, Mexico City, Mexico., Rivero-Arrieta A; Departamento de Investigación en Enfermedades Infecciosas, INER, Mexico City, Mexico., Kuri-Cervantes L; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gunzelman HM; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gostick E; Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK., Price DA; Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK., Koup RA; Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA., Naji A; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Canaday DH; Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, OH, USA; Division of Geriatric Research, Louis Stokes VA Medical Center, Cleveland, OH, USA., Reyes-Terán G; Departamento de Investigación en Enfermedades Infecciosas, INER, Mexico City, Mexico., Betts MR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: betts@pennmedicine.upenn.edu.

Publikováno v: Cell reports [Cell Rep] 2017 Dec 19; Vol. 21 (12), pp. 3458-3470.