Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Guntram Suske"'
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007193 (2018)
Diverse Polycomb repressive complexes 1 (PRC1) play essential roles in gene regulation, differentiation and development. Six major groups of PRC1 complexes that differ in their subunit composition have been identified in mammals. How the different PR
Externí odkaz:
https://doaj.org/article/a6b392f27dfd44ddb3f72dd5445ab6fe
Autor:
Sara Völkel, Bastian Stielow, Florian Finkernagel, Thorsten Stiewe, Andrea Nist, Guntram Suske
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005102 (2015)
Transcription factors are grouped into families based on sequence similarity within functional domains, particularly DNA-binding domains. The Specificity proteins Sp1, Sp2 and Sp3 are paradigmatic of closely related transcription factors. They share
Externí odkaz:
https://doaj.org/article/9b3bc3d3b37f4917944cc17711979289
Autor:
Harald Braun, Guntram Suske
Publikováno v:
BioTechniques, Vol 26, Iss 6, Pp 1038-1042 (1999)
Externí odkaz:
https://doaj.org/article/dafdb171151341af83086b31666b24fe
Autor:
Rolf Diezko, Guntram Suske
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66947 (2013)
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated nuclear receptor regulating adipogenesis, glucose homeostasis and inflammatory responses. The activity of PPARγ is controlled by post-translational modifications includi
Externí odkaz:
https://doaj.org/article/0439c0997edb43848f248d99f83c6efb
Autor:
Bastian Stielow, Imme Krüger, Rolf Diezko, Florian Finkernagel, Nynke Gillemans, John Kong-a-San, Sjaak Philipsen, Guntram Suske
Publikováno v:
PLoS Genetics, Vol 6, Iss 11, p e1001203 (2010)
SUMO modification of transcription factors is linked to repression of transcription. The physiological significance of SUMO attachment to a particular transcriptional regulator, however, is largely unknown. We have employed the ubiquitously expressed
Externí odkaz:
https://doaj.org/article/9e85d90ff03d42879c120e667850bfeb
Autor:
Frank Baur, Kerstin Nau, Dennis Sadic, Lena Allweiss, Hans-Peter Elsässer, Nynke Gillemans, Ton de Wit, Imme Krüger, Marion Vollmer, Sjaak Philipsen, Guntram Suske
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9587 (2010)
BACKGROUND: The zinc finger protein Sp2 (specificity protein 2) is a member of the glutamine-rich Sp family of transcription factors. Despite its close similarity to Sp1, Sp3 and Sp4, Sp2 does not bind to DNA or activate transcription when expressed
Externí odkaz:
https://doaj.org/article/9310873f1b3943e4bef3e5cde6692409
Autor:
Guntram Suske
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1860:590-597
For long it has been recognized that CCAAT boxes and GC-rich elements co-occur in many human and murine promoters within 100bp upstream of the transcription start site. The trimeric transcription factor NF-Y is the major CCAAT box-binding factor, and
Autor:
Melanie Küspert, Elisabeth Sock, Michael Wegner, Amélie Wegener, Sjaak Philipsen, Guntram Suske
Publikováno v:
Journal of Neurochemistry, 140(2), 245-256. Wiley-Blackwell Publishing Ltd
Oligodendrocytes and Schwann cells are the myelinating glia of the vertebrate nervous system and by generation of myelin sheaths allow rapid saltatory conduction. Previous in vitro work had pointed to a role of the zinc finger containing specificity
Autor:
Thorsten Stiewe, Dana Berger, Sara Völkel, Bastian Stielow, Florian Finkernagel, Andrea Nist, Guntram Suske
Publikováno v:
The Journal of biological chemistry. 293(50)
Different transcription factors operate together at promoters and enhancers to regulate gene expression. Transcription factors either bind directly to their target DNA or are tethered to it by other proteins. The transcription factor Sp2 serves as a
Autor:
Erikjan Rijkers, Laura Gutierrez, Hans Janssen, Harmen J.G. van de Werken, Marjolein Meinders, Rutger W W Brouwer, Guntram Suske, Timo K. van den Berg, Sjaak Philipsen, Wilfred F. J. van IJcken, Mark Hoogenboezem, Imme Krüger, Jeroen Demmers, Divine I. Kulu
Publikováno v:
Meinders, M, Kulu, D I, van de Werken, H J G, Hoogenboezem, M, Janssen, H, Brouwer, R W W, van Ijcken, W F J, Rijkers, E-J, Demmers, J A A, Krüger, I, van den Berg, T K, Suske, G, Gutiérrez, L & Philipsen, S 2015, ' Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function ', Blood, vol. 125, no. 12, pp. 1957-67 . https://doi.org/10.1182/blood-2014-08-593343
Blood, 125(12), 1957-67. American Society of Hematology
Blood, 125(12), 1957-1967. American Society of Hematology
Blood, 125(12), 1957-67. American Society of Hematology
Blood, 125(12), 1957-1967. American Society of Hematology
Sp1 and Sp3 belong to the specificity proteins (Sp)/Krüppel-like transcription factor family. They are closely related, ubiquitously expressed, and recognize G-rich DNA motifs. They are thought to regulate generic processes such as cell-cycle and gr