Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gunther Riess"'
Autor:
Thomas C. Merigan, A Dunkler, Jan Balzarini, D Oette, J P Kleim, Irvin Winkler, J R Suarez, Mark A. Winters, Gunther Riess
Publikováno v:
The Journal of Infectious Diseases. 179:709-713
The safety and antiviral activity of the second-generation nonnucleoside inhibitor HBY 097 was investigated in asymptomatic or mildly symptomatic human immunodeficiency virus (HIV)-1-infected patients in a randomized, double-blinded, dose-escalation
Autor:
Edward Arnold, Gunther Riess, Stephen H. Hughes, Irvin Winkler, Y. Hsiou, Arthur D. Clark, Manfred Rösner, Jianping Ding, Kalyan Das, Jörg Peter Kleim
Publikováno v:
Journal of Molecular Biology. 284:313-323
The second generation Hoechst-Bayer non-nucleoside inhibitor, HBY 097 ( S -4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-dihydroqui noxalin-2(1 H )-thione), is an extremely potent inhibitor of HIV-1 reverse transcriptase (RT) and of HIV-1 i
Autor:
Gunther Riess, Erik De Ckrcq, Heidi Pelemans, Irvin Winkler, Jörg-Peter Kleim, Jan Balzarini, Manfred Dr Roesner
Publikováno v:
Biochemical Pharmacology. 55:617-625
An azidothymidine (AZT)-resistant virus strain (HIV-1/AZT) (containing the 67 Asp → Asn, 70 Lys → Arg, 215 Thr → Phe and 219 Lys → Gln mutations into its reverse transcriptase) was grown in the combined presence of 2′,3t - dideoxy-3′-thia
Autor:
Irvin Winkler, M. Roesner, Heidi Pelemans, Jan Balzarini, J P Kleim, E. De Clercq, Gunther Riess
Publikováno v:
The Journal of Infectious Diseases. 176:1392-1397
Replication of zidovudine-resistant human immunodeficiency virus type 1 (HIV-1) strains (containing the 41 Met-->Leu and 215 Thr-->Tyr mutations in reverse transcriptase [RT]) was inhibited to a significantly greater extent by the combination of lami
Autor:
Y. Hsiou, Reinhard Kirsch, Irvin Winkler, Gunther Riess, Manfred Rösner, Edward Arnold, Arno Paessens, Jorg-Peter Kleim
Publikováno v:
Proceedings of the National Academy of Sciences. 93:34-38
The quinoxaline nonnucleoside RT inhibitor (NNRTI) (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4- dihydroquinoxaline-2(1H)-thione (HBY 097) was used to select for drug-resistant HIV-1 variants in vitro. The viruses first developed mutat
Autor:
Jörg-Peter Kleim, Arno Paessens, Manfred Rösner, Gunther Riess, Reinhard Kirsch, Helga Rübsamen-Waigmann, Irvin Winkler
Publikováno v:
Virology. 231(1)
In vitro resistance of HIV-1 against high levels of HBY 097 (( S )-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-dihydro-quinoxaline-2(1 H )-thione) and other quinoxaline nonnucleoside reverse transcriptase inhibitors (NNRTIs) is characteri
Publikováno v:
Virology. 200(2)
S-2720 and other members of the quinoline/quinoxaline class of HIV-1-specific nonnucleoside reverse transcriptase inhibitors (NNRTIs) select for a glycine to glutamate substitution at residue 190 (Gly 190 Glu) of the reverse transcriptase (RT), when