Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Gunther Jansen"'
Publikováno v:
PLoS Biology, Vol 16, Iss 4, p e2004356 (2018)
The spread of antibiotic resistance is always a consequence of evolutionary processes. The consideration of evolution is thus key to the development of sustainable therapy. Two main factors were recently proposed to enhance long-term effectiveness of
Externí odkaz:
https://doaj.org/article/787972009bb94014b5789db5601235fa
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186175 (2017)
Precision medicine attempts to individualize cancer therapy by matching tumor-specific genetic changes with effective targeted therapies. A crucial first step in this process is the reliable identification of cancer-relevant variants, which is consid
Externí odkaz:
https://doaj.org/article/8106aaef3fd743e59c87bc1c68a798d3
Publikováno v:
European Journal of Entomology, Vol 108, Iss 1, Pp 53-62 (2011)
The parasitic caterpillars of Maculinea (Lepidoptera: Lycaenidae) need to be adopted and nursed by ants of the genus Myrmica (Hymenoptera: Formicidae). Each Maculinea species is locally associated with one or a few main and often several secondary ho
Externí odkaz:
https://doaj.org/article/2e059aed53e24bdfa31830ebe55f1e1e
Autor:
Ayari Fuentes-Hernandez, Jessica Plucain, Fabio Gori, Rafael Pena-Miller, Carlos Reding, Gunther Jansen, Hinrich Schulenburg, Ivana Gudelj, Robert Beardmore
Publikováno v:
PLoS Biology, Vol 13, Iss 4, p e1002104 (2015)
We need to find ways of enhancing the potency of existing antibiotics, and, with this in mind, we begin with an unusual question: how low can antibiotic dosages be and yet bacterial clearance still be observed? Seeking to optimise the simultaneous us
Externí odkaz:
https://doaj.org/article/7741a185edc84b788c3451d9ddb55634
Autor:
Rafael Pena-Miller, David Laehnemann, Gunther Jansen, Ayari Fuentes-Hernandez, Philip Rosenstiel, Hinrich Schulenburg, Robert Beardmore
Publikováno v:
PLoS Biology, Vol 11, Iss 4, p e1001540 (2013)
Conventional wisdom holds that the best way to treat infection with antibiotics is to 'hit early and hit hard'. A favoured strategy is to deploy two antibiotics that produce a stronger effect in combination than if either drug were used alone. But ar
Externí odkaz:
https://doaj.org/article/070ccd08a7cd4ce0ba3a11bf439ee3f1
Autor:
Niels Mahrt, Gunther Jansen, Sören Franzenburg, Sven Künzel, Camilo Barbosa, Hinrich Schulenburg, Alexandra Tietze
Publikováno v:
Nature Ecology & Evolution
During antibiotic treatment, the evolution of bacterial pathogens is fundamentally affected by bottlenecks and varying selection levels imposed by the drugs. Bottlenecks—that is, reductions in bacterial population size—lead to an increased influe
Autor:
Carlos Reding, Robert E. Beardmore, Gunther Jansen, Phillip Rosenstiel, Hinrich Schulenburg, Pablo Catalán, Tobias Bergmiller, Ivana Gudelj, Emily Wood
Publikováno v:
Molecular Biology and Evolution
e-Archivo. Repositorio Institucional de la Universidad Carlos III de Madrid
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e-Archivo. Repositorio Institucional de la Universidad Carlos III de Madrid
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To determine the dosage at which antibiotic resistance evolution is most rapid, we treated Escherichia coli in vitro, deploying the antibiotic erythromycin at dosages ranging from zero to high. Adaptation was fastest just below erythromycin’s minim
Autor:
Hinrich Schulenburg, Gunther Jansen, Niels Mahrt, Philip Rosenstiel, Matthias Graßer, Julia Bunk, Camilo Barbosa
Publikováno v:
Molecular Biology and Evolution
Combination therapy is a common antibiotic treatment strategy that aims at minimizing the risk of resistance evolution in several infectious diseases. Nonetheless, evidence supporting its efficacy against the nosocomial opportunistic pathogen Pseudom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2fc7615289595ac0fb41bc908b7aca
https://hdl.handle.net/21.11116/0000-0007-AD67-321.11116/0000-0007-AD69-1
https://hdl.handle.net/21.11116/0000-0007-AD67-321.11116/0000-0007-AD69-1
Autor:
Gunther Jansen, Hinrich Schulenburg, Pablo Catalán, Ivana Gudelj, Carlos Reding, Phillip Rosenstiel, Robert E. Beardmore, Tobias Bergmiller
We treatedEscherichia coliwith the antibiotic erythromycin from zero to high dosages to determine how the evolutionary dynamics of antibiotic resistant phenotypes and genotypes depend on dose. The most rapid increase in resistance was observed just b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888b16efe9dffc7a80a97da579215a88
Publikováno v:
Journal of Clinical Oncology. 39:1547-1547
1547 Background: IMpower150 was a phase 3 clinical trial that evaluated the efficacy of atezolizumab in patients with metastatic nonsquamous NSCLC; it demonstrated no significant OS benefit in the ACP (atezolizumab+carboplatin+paclitaxel) arm vs the