Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial

Autor: Jan Brzezicki, Ramon Toro-Torres, Juan Cruz Rizo Rodriguez, Eric C. Mueller, Atul Deodhar, Anna Dudek, Gunther Neeck, Roger J. Diegel, Maria Greenwald, Lianne S. Gensler, Hitoshi Goto, Judith Carrio, Seung Jae Hong, Cassandra M. Skinner, Yoshinori Taniguchi, Tatsuya Atsumi, Mikkel Østergaard, Shigeru Honjo, Clemens Scheinecker, Heinrich Resch, Rafal Plebanski, Yoshifuji Matsumoto, David H. Adams, Min Chan Park, Richard Roseff, David H. Goddard, Hiroaki Dobashi, Steven C. Kimmel, Johannes Grisar, Christine Thai, Sergio Duran Barragan, Chang Keun Lee, Tetsuya Tomita, Frederic Morin, Roel Querubin, Jose Maldonado Cocco, Craig D. Scoville, Philip J. Mease, Luminita Tronaru, Kurisu Tada, Denis Poddubnyy, Mohamed B. Sebai, Federico Ariel, Eleonora Lucero, Mark D. Harris, Kari K. Eklund, Melvin Churchill, Jeffrey L. Kaine, Cesar Ricardo Ramos Remus, Francisco Fidencio Cons Molina, Kazuhiro Hatta, Eun Bong Lee, Joachim Sieper, Alan Kivitz, Yukitaka Ueki, Jorge Velasco, Seong Wook Kang, Jürgen Braun, Sang-Heon Lee, Xiaoqi Li, Kentaro Inui, Leena Paimela, Michael E. Sayers, Arthur R. Mabaquiao, Antonio Scafuto Scotton, Sylke Wagner, Carlos Pantojas, Janina Drabiszcak-Piatkowska, Ana Maria Ramazan, Steven J. Klein, Proton Rahman, M. Hojnik, Marleen G H van de Sande, Tania L. Rivera, Amarilis Perez-De Jesus, Kathleen P. Flint, Jyothi R. Mallepalli, John E. Hull, Karel Pvelka, Evgeniya Schmidt, Mary P. Howell, Yuya Takakubo, Gaia Gallo, Walter P. Maksymowych, Joseph C. Shanahan, Marek Krogulec, Aaron Alejandro Barrera Rodriguez, Cesar Francisco Pacheco Tena, Anna Karjalainen, Pentti Jarvinen, Oscar Soto-Raices, Zdenek Dvorak, Désirée van der Heijde, Tokutaro Tsuda, Galina Matsievskaya, Sergey Yakushin, Eva Dokoupilova, Ann Leung, Luis Roimicher, Daniela Opris-Belinski, Pawel Hrycai, Tomasz Blicharshi, Kiyoshi Matsui, Hilde Carlier, Olga Ershova, Alberto Berman, Tae-Hwan Kim, Eric A. Peters, Marina Stanislav, Ana Claudia Melazzi, Martina Malcova, Louis Bessette, Sang-Hoon Lee, Helena Marzo-Ortega, Andrey Rebroy, Diego O. Viola, Rodolfo A Pardo Hidalgo

Publikováno v: Lancet, 395(10217), 53-64
Lancet, 395(10217), 53-64. Elsevier Limited

Summary Background Ixekizumab, a high-affinity interleukin-17A (IL-17A) monoclonal antibody, has previously shown efficacy in radiographic axial spondyloarthritis (also known as ankylosing spondylitis). We aimed to evaluate the efficacy and safety of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de58e8a78134c8e494ab8c28ac8b159f
https://hdl.handle.net/1887/3181441

Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with biological disease-modifying anti-rheumatic drugs (COAST-V): 16 week results of a phase 3 randomised, double-blind, active-controlled and placebo-controlled trial

Autor: Maxime Dougados, Yukitaka Ueki, E. Drescher, Cesar Ricardo Ramos Remus, Chang Keun Lee, James Cheng-Chung Wei, Robert Landewé, Atul Deodhar, Martina Malcova, Geoffrey Gladstein, Cesar Francisco Pacheco Tena, Kichul Shin, Yoshinobu Koyama, Sergey Yakushin, Jeffrey L. Kaine, Philip J. Mease, Fangyi Zhao, Andrea Rubbert-Roth, Rafal Wojciechowski, Mary P. Howell, Yuya Takakubo, Proton Rahman, Filip Van den Bosch, Kurisu Tada, Olga Ershova, Mitsumasa Kishimoto, Gunther Neeck, Kathleen P. Flint, Hilde Carlier, Song-Chou Hsieh, Artur Racewicz, Hitoshi Goto, Tae-Hwan Kim, Ying-Chou Chen, Gyula Poor, Eric A. Peters, Roger J. Diegel, Maria Greenwald, Galina Matsievskaya, Tatsuya Atsumi, Marleen G H van de Sande, Tibor Balazs, Frederic Morin, Louis Bessette, Juan Cruz Rizo Rodriguez, Seong Wook Kang, Fidencio Cons-Molina, Sergio Duran Barragan, Kentaro Inui, Seung-Jae Hong, Evgeniya Shmidt, Christine Thai, Kiyoshi Matsui, Eswar Krishnan, Radka Moravcova, Ji Hyeon Ju, Sang-Heon Lee, Désirée van der Heijde, Regina Cseuz, Aaron Alejandro Barrera Rodriguez, Joachim Sieper, Anna Dudek, Denis Poddubnyy, Zdenek Dvorak, Yeon-Ah Lee, Daksha Mehta, Michael T. Nurmohamed, Ed Griep, David H. Adams, Joung-Liang Lan, Hiroaki Dobashi, Yoshinori Taniguchi, Tetsuya Tomita, Eun Bong Lee, Yoshifuji Matsumoto, Cassandra M. Skinner, Roel Querubin, Richard Roseff, Hung-An Chen, Walter P. Maksymowych, John D. Reveille, A P Rebrov, Melvin Churchill, Akgun Ince, Sang-Hoon Lee, Marina Stanislav, Malgorzata Szymanska, Min Chan Park, Kazuhiro Hatta, Beth A. Pangallo, Tomasz Blicharski

Publikováno v: Lancet, 392(10163), 2441-2451. Elsevier Limited
Lancet, 392(10163), 2441-2451

Background: Biological disease-modifying anti-rheumatic drugs (bDMARDs) are recommended for radiographic axial spondyloarthritis, otherwise known as ankylosing spondylitis, when conventional therapies are not effective. We report efficacy and safety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0bc1de5bba57ee7653b1a03a4b6a92
https://pure.amc.nl/en/publications/ixekizumab-an-interleukin17a-antagonist-in-the-treatment-of-ankylosing-spondylitis-or-radiographic-axial-spondyloarthritis-in-patients-previously-untreated-with-biological-diseasemodifying-antirheumatic-drugs-coastv-16-week-results-of-a-phase-3-randomised-doubleblind-activecontrolled-and-placebocontrolled-trial(e51525e9-21e1-4de6-8b88-83f1151d2c97).html

[CMV associated acute liver failure in a patient receiving tocilizumab for systemic lupus erythematosus]

Autor: Sophie, Fromhold-Treu, Andreas, Erbersdobler, Manuela, Turan, Gunther, Neeck, Georg, Lamprecht

Publikováno v: Zeitschrift fur Gastroenterologie. 55(5)

A 41-year-old female patient was admitted because of febrile jaundice and acute liver failure. The quick and the bilirubin were 21 % and 258 µmol/l, and there was hepatic encephalopathy I°. AST and AP had a maximum of 612 and 215 U/l. Despite a str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff439bc90af33f725b9aa470760ace88
https://pubmed.ncbi.nlm.nih.gov/28499323

The impact of HLA-DRB alleles on the subclass titres of antibodies against citrullinated peptides

Autor: Robby Engelmann, Brigitte Mueller-Hilke, Gunther Neeck, Martin Eggert

Publikováno v: Rheumatology. 49:1862-1866

Objectives. The association between HLA-DR haplotypes and RA have been well established. However, the molecular mechanisms of how HLA mediates susceptibility and/or progression of the disease remain elusive. We therefore turned to the RA-specific ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84695af79e2598f8d14053ba785a8c77
https://doi.org/10.1093/rheumatology/keq179

Changes in the activation level of NF-kappa B in lymphocytes of MS patients during glucocorticoid pulse therapy

Autor: Uwe K. Zettl, Martin Eggert, Silvia Dilk, Gunther Neeck, Robert Goertsches, Ulrike Seeck

Publikováno v: Journal of the Neurological Sciences. 264:145-150

Nuclear factor-kappaB activity was analyzed in multiple sclerosis (MS) patients during the course of a methylprednisolone pulse therapy. Molecular effects were evaluated using lymphocytes derived from 20 MS patients before and after therapy and 24 he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da29bb02a4c4718c3e865cd61e34481f
https://doi.org/10.1016/j.jns.2007.08.026