Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Gunter Trummlitz"'
Publikováno v:
European Journal of Pharmaceutical Sciences. 4:175-187
The physicochemical properties of meloxicam, a new NSAID, were investigated. Dependent on pH and solvents used, X-ray crystallography showed that meloxicam crystallized in four different prototropic forms; the anion, the acidic enol, the zwitterion a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87db1b48e30024f599f2fc8c9d9f987c
https://doi.org/10.1016/0928-0987(95)00046-1
https://doi.org/10.1016/0928-0987(95)00046-1
Autor:
J. van Ryn, Michel Pairet, Guenther Dr Engelhardt, Hans Schierok, Gunter Trummlitz, Annerose Mauz
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 47(6)
Objective and Design: Two structurally related compounds, meloxicam (Mel) and its structural 4′-isomer (4′-Mel), were compared to examine the role of a slightly different chemical structure on cyclooxygenase (COX) selectivity in in vitro and in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f9e674408544bae5c45223b4246166
https://pubmed.ncbi.nlm.nih.gov/9683035
https://pubmed.ncbi.nlm.nih.gov/9683035
Autor:
Sorcek Ronald J, Simon J. Coutts, L. Churchill, Eva David, Mcneil Daniel W, Gunter Trummlitz, Hin-Chor Wong, Peter M. Grob, Ian Potocki, Hans Meier, Matt Aaron Tschantz, Wolfhard Engel, Lazer Edward S, Miao Clara K, A. G. Graham, Terence A. Kelly, Charles L. Cywin, Maryann Hoermann, Zhaoxing Meng, Roger J. Snow
Publikováno v:
Journal of medicinal chemistry. 40(6)
Meloxicam (5), an NSAID in the enol-carboxamide class, was developed on the basis of its antiinflammatory activity and relative safety in animal models. In subsequent screening in microsomal assays using human COX-1 and COX-2, we discovered that it p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50186f66868fad80b86b655e901a13d8
https://pubmed.ncbi.nlm.nih.gov/9083488
https://pubmed.ncbi.nlm.nih.gov/9083488
Publikováno v:
Side Effects of Anti-Inflammatory Drugs IV ISBN: 9789401062695
The discovery of an inducible isoform of cyclooxygenase (COX-2) requires a refinement of the theory that inhibition of cyclooxygenase activity is responsible for both therapeutic and side-effects of nonsteroidal anti-inflammatory drugs (NSAIDs). Phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b659d63228284001c3a450f27ac83ad1
https://doi.org/10.1007/978-94-011-5394-2_23
https://doi.org/10.1007/978-94-011-5394-2_23
