Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Gunter Tremp"'
Autor:
Allal Boutajangout, Michèle Authelet, Véronique Blanchard, N Touchet, Gunter Tremp, Laurent Pradier, Jean-Pierre Brion
Publikováno v:
Neurobiology of Disease, Vol 15, Iss 1, Pp 47-60 (2004)
To study the role of Aβ amyloid deposits in the generation of cytoskeletal lesions, we have generated a transgenic mouse line coexpressing in the same neurons a wild-type human tau isoform (0N3R), a mutant form of APP (751SL) and a mutant form of PS
Externí odkaz:
https://doaj.org/article/e9b76f3062f341f7a043596e7b8f0ccb
Autor:
Nicole Feldmann, Gerd Multhaup, Christian Czech, Laurent Pradier, Konrad Beyreuther, Véronique Blanchard, Oliver Wirths, Thomas A. Bayer, Gunter Tremp
Publikováno v:
Brain Pathol
Neuropil deposition of beta-amyloid peptides A beta40 and A beta42 is believed to be the key event in the neurodegenerative processes of Alzheimer's disease (AD). Since A beta seems to carry a transport signal that is required for axonal sorting of i
Autor:
Charles Duyckaerts, Laurent Pradier, Nathalie Touchet, Luc Mercken, Nicolas Sergeant, André Delacourte, Gunter Tremp, Dominique Santiard-Baron, Dominique Langui, Benoît Delatour, Véronique Blanchard, Brigitte Schombert, Maryse Delehedde, Marie-Françoise Paul
Publikováno v:
Journal of Neurochemistry. 93:330-338
FE65 is an adaptor protein that interacts with the cytoplasmic tail of the amyloid precursor protein (APP). In cultured non-neuronal cells, the formation of the FE65-APP complex is a key element for the modulation of APP processing, signalling and be
Autor:
Ichiro Shiojima, Yuri Ivashchenko, Masahiro Ito, Wilson S. Colucci, Ronglih Liao, Christoph Kuester, Yoshiaki Taniyama, Kenneth Walsh, Gunter Tremp, Kerstin Veit, Kaori Sato
Publikováno v:
Journal of Molecular and Cellular Cardiology. 38:375-385
Akt is a serine/threonine kinase that mediates a variety of cellular responses to external stimuli. Among the three members of mammalian Akt (Akt1, Akt2 and Akt3), Akt3 is unique in that it has an alternatively spliced variant that lacks the carboxy-
Autor:
Hervé Drobecq, Nicolas Sergeant, Jesus Benavides, Oliver Wirths, Véronique Blanchard, Thierry Canton, Valérie Vingtdeux, Gunter Tremp, Nicolien M. van der Kolk, Laurent Pradier, Evita van de Steeg, Christoph Schmitz, Bruno Bonici, Gwenaelle Ret, André Delacourte, Caty Casas, Jean-Michel Itier, Patrick Benoit, Thomas A. Bayer, Allan Clark
Publikováno v:
The American Journal of Pathology. 165:1289-1300
Alzheimer's disease (AD) is characterized by a substantial degeneration of pyramidal neurons and the appearance of neuritic plaques and neurofibrillary tangles. Here we present a novel transgenic mouse model, APP(SL)PS1KI that closely mimics the deve
Autor:
Jean Pierre Brion, Gunter Tremp, Nathalie Touchet, Laurent Pradier, Allal Boutajangout, Véronique Blanchard, Michèle Authelet
Publikováno v:
Neurobiology of Disease, Vol 15, Iss 1, Pp 47-60 (2004)
To study the role of Abeta amyloid deposits in the generation of cytoskeletal lesions, we have generated a transgenic mouse line coexpressing in the same neurons a wild-type human tau isoform (0N3R), a mutant form of APP (751SL) and a mutant form of
Autor:
Laurent Pradier, Micheline Gohin, Thomas A. Bayer, Dominique Langui, Christian Czech, Véronique Blanchard, Charles Duyckaerts, Thierry Canton, Nathalie Touchet, Michel Planche, Saliha Moussaoui, Gunter Tremp, Oliver Wirths, Bruno Bonici, Iness Jedidi
Publikováno v:
Experimental Neurology. 184:247-263
Several novel transgenic mouse models expressing different mutant APPs in combination with mutant PS1 have been developed. These models have been analyzed to investigate the formation and progressive alterations of dystrophic neurites (DNs) in relati
Autor:
Nacer Abbas, Patrice Denefle, Jeremy Pratt, Maria Angeles Mena, Gunter Tremp, Thomas Rooney, Eva Gallego, Marina P. Sánchez, Gwénnäelle Ret, Francisco Araujo, Chantal Joubert, Justo García de Yébenes, Pablo Ibanez, Alexis Brice, Rosa M. Solano, Olga Corti, Charles Cohen-Salmon, Jean Michel Itier, Laurent Pradier, Michel Laville, Magali Periquet, Santiago Canals, Alba Serrano, María José Casarejos, Julia Negroni, Georg Andrees Bohme, Jesus Benavides
Publikováno v:
Human Molecular Genetics. 12:2277-2291
Mutations of the parkin gene are the most frequent cause of early onset autosomal recessive parkinsonism (EO-AR). Here we show that inactivation of the parkin gene in mice results in motor and cognitive deficits, inhibition of amphetamine-induced dop
Autor:
Jacques Hugon, Gunter Tremp, Catherine Yardin, Laurent Pradier, Françoise Esclaire, Marie-Claire Baclet, Faraj Terro, Nathalie Touchet, Wassim Elyaman, Christian Czech
Publikováno v:
Journal of Neuroscience Research. 69:530-539
Most early-onset cases of familial Alzheimer's disease (FAD) are linked to mutations in two related genes, ps1 and ps2. FAD-linked mutant PS1 alters proteolytic processing of the amyloid precursor protein and increases vulnerability to apoptosis indu
Autor:
Jean Pierre Brion, Laurent Pradier, Michèle Authelet, Allal Boutajangout, Nathalie Touchet, Véronique Blanchard, Karelle Leroy, Gunter Tremp
Publikováno v:
Neuroscience Letters. 318:29-33
Neurofibrillary tangles, composed of tau proteins, are a key lesion observed in sporadic forms of Alzheimer's disease and in familial forms associated with mutations of presenilin-1 (PS1). We have generated a double transgenic mouse line expressing a