Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Gunter Grupp"'
Autor:
G. Roger Askew, Alison L. Woo, Ingrid L. Grupp, Jerry B. Lingrel, Richard A. Walsh, Gunter Grupp, Paul F. James, Michelle L. Croyle
Publikováno v:
Molecular Cell. 3:555-563
It is well accepted that inhibition of the Na,K-ATPase in the heart, through effects on the Na/Ca exchanger, raises the intracellular Ca2+ concentration and strengthens cardiac contraction. However, the contribution that individual isoforms make to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407d2f50deb7c5ea7c2c39235fc46c23
https://doi.org/10.1016/s1097-2765(00)80349-4
https://doi.org/10.1016/s1097-2765(00)80349-4
Autor:
Muthu Periasamy, Ingrid L. Grupp, Evgeny Loukianov, Richard A. Walsh, Gunter Grupp, Jonathan Lytton, Tanya Loukianova, Darryl L. Kirkpatrick, Yong Ji, Debra L. Baker
Publikováno v:
Circulation Research. 83:889-897
Abstract —In this study, we investigated whether the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca 2+ transport pump (SERCA1a) can functionally substitute the cardiac SERCA2a isoform and how its overexpression affects cardiac contract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9098c83a1cc5d0a6320a449c234e0a34
https://doi.org/10.1161/01.res.83.9.889
https://doi.org/10.1161/01.res.83.9.889
Autor:
Beata M. Wolska, Ingrid L. Grupp, Gunter Grupp, Jay Patrick Slack, Evangelia G. Kranias, Kobra Haghighi, Thomas Doetschman, Wusheng Luo, Judy M. Harrer, R. John Solaro, Donald G. Ferguson
Publikováno v:
Circulation Research. 78:839-847
Abstract Phospholamban ablation has been shown to result in significant increases in cardiac contractile parameters and loss of β-adrenergic stimulation. To determine whether partial reduction in phospholamban levels is also associated with enhancem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064c3ba828cf1393274ab7b0899d43a0
https://doi.org/10.1161/01.res.78.5.839
https://doi.org/10.1161/01.res.78.5.839
Autor:
John J. Duffy, Ingrid L. Grupp, Judy M. Harrer, Thomas Doetschman, Wusheng Luo, Sathivel Ponniah, Gunter Grupp, Evangelia G. Kranias
Publikováno v:
Circulation Research. 75:401-409
Phospholamban is the regulator of the Ca(2+)-ATPase in cardiac sarcoplasmic reticulum (SR), and it has been suggested to be an important determinant in the inotropic responses of the heart to beta-adrenergic stimulation. To determine the role of phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5d09bf09b8b346b54228496eba4ba4
https://doi.org/10.1161/01.res.75.3.401
https://doi.org/10.1161/01.res.75.3.401
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 265:H1401-H1410
It is now possible to manipulate the murine genome and produce transgenic mice in which genes encoding myocardial proteins have been ablated, resulting in an altered myocardial performance. In this study, we quantitate myocardial performance in work-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e10f9fe7b27a3c09aa90029f89ab32
https://doi.org/10.1152/ajpheart.1993.265.4.h1401
https://doi.org/10.1152/ajpheart.1993.265.4.h1401
Publikováno v:
Developments in Cardiovascular Medicine ISBN: 9781461356615
Over the past ten years an abundance of transgenic mouse models (gene ablations, overexpressions, or mutations) with variable consequences on heart function have become available. Consequently, quantitative methods had to be developed to analyze card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ec3e632efeac053afcabff56832cfb0
https://doi.org/10.1007/978-1-4615-1653-8_9
https://doi.org/10.1007/978-1-4615-1653-8_9
Autor:
William Lewis, Randal E. Morris, Brian D. Hoit, Allen M. Samarel, Gunter Grupp, Ingrid L. Grupp, Paul E. Klotman, Leslie A. Bruggeman
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 80(2)
Cardiomyopathy in AIDS is an increasingly important clinical problem. Mechanisms of AIDS cardiomyopathy were explored using AIDS transgenic mice that express replication-incompetent HIV-1 (NL4-3delta gag/pol). Transgenic and FVB/n mice (n = 3 to 6 pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3c18dd135bafb82d6c2ebbaffd9a4a
https://pubmed.ncbi.nlm.nih.gov/10701688
https://pubmed.ncbi.nlm.nih.gov/10701688
Autor:
Evangelia G. Kranias, István Édes, Ingrid L. Grupp, Gunter Grupp, Eva Kiss, Angela G. Brittsan
Publikováno v:
Journal of molecular and cellular cardiology. 31(9)
The aim of the present study was to determine the effects of beta -adrenergic stimulation in wild-type and phospholamban-deficient mouse hearts with altered thyroid conditions. Hypothyroidism was associated with significant decreases in heart/body we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eae431fd69657dea2b3e3c5f07a7ae6
https://pubmed.ncbi.nlm.nih.gov/10471356
https://pubmed.ncbi.nlm.nih.gov/10471356
Autor:
Ajit Bhagwhat, Yong Ji, Evgenij Loukianov, Debra L. Baker, Brian D. Hoit, Gunter Grupp, Ingrid L. Grupp, Richard A. Walsh, Muthu Periasamy, Eduardo Marbán, Thomas D. Reed, Katsuji Hashimoto
Publikováno v:
Circulation research. 83(12)
Abstract —Cardiac hypertrophy and heart failure are known to be associated with a reduction in Ca 2+ -ATPase pump levels of the sarcoplasmic reticulum (SR). To determine whether, and to what extent, alterations in Ca 2+ pump numbers can affect cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf9791e56a2f720a2a3f2cbddd0149d
https://pubmed.ncbi.nlm.nih.gov/9851937
https://pubmed.ncbi.nlm.nih.gov/9851937