Výsledky vyhledávání - "Gunter Ehrlich"

Thermodynamic profile of mutual subunit control in a heteromeric receptor

Autor: Eckhard Schulz, Michele Bonus, Christian Sattler, Thomas Zimmer, Melanie Wiegand, Ralf Schmauder, Klaus Benndorf, Nisa Kosmalla, Holger Gohlke, Taulant Kukaj, Thomas Eick, Gunter Ehrlich, Tina Schwabe, Jan L. Münch, Jana Schirmeyer, Sabine Hummert

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(30), e2100469118 (2021). doi:10.1073/pnas.2100469118

Significance Membrane receptors control innumerous essential functions of living cells and are proven drug targets for pharmacological interventions. Many receptors are composed of a number of subunits and contain multiple binding sites for ligands,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958ee041afd71a562ab3c4251498b6ca
http://europepmc.org/articles/PMC8325370

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All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner

Autor: Gunter Ehrlich, Jana Kusch, Tina Schwabe, Mallikarjuna Rao Sunkara, Klaus Benndorf

Publikováno v: The Journal of General Physiology

HCN pacemaker channels are dually gated by hyperpolarizing voltages and cyclic nucleotide binding. Sunkara et al. show that each of the four binding sites promotes channel opening, most likely by exerting a turning momentum on the tetrameric intracel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb2c211313336d423926890dea7fe42
https://pubmed.ncbi.nlm.nih.gov/29959170

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Overlapping and distinct roles for PI3Kβ and γ isoforms in S1P-induced migration of human and mouse endothelial cells

Autor: Sherry N Hsieh, Qing Chang, Peter J Kuhlencordt, Gunter Ehrlich, Regine Heller, Klaus T. Preissner, Simone M. Schoenwaelder, Reinhard Wetzker, Emilio Hirsch

Publikováno v: Cardiovascular Research. 80:96-105

Sphingosine-1-phosphate (S1P), a key regulator of vascular homeostasis and angiogenesis, promotes endothelial cell migration via stimulation of phosphoinositide 3-kinase (PI3K). The aim of this study was to identify the role of PI3Kbeta and gamma iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d8d82efe3b8232e5b9e08ee16d94aa
https://doi.org/10.1093/cvr/cvn159

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Non-pathogenic trypanosomatid protozoa as a platform for protein research and production

Autor: Gunter Ehrlich, Reinhard Breitling, Anett Geyer, Regina Pietrucha, Stephen M. Beverley, Roland Contreras, Regina Hartung, Angelika Müller, Nico Callewaert, Susanne Klingner, Kirill Alexandrov

Publikováno v: Protein Expression and Purification. 25:209-218

All currently existing eukaryotic protein expression systems are based on autonomous life forms. To exploit the potential practical benefits associated with parasitic organisms we have developed a new protein expression system based on Leishmania tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a29e058db4cd3e72b93a88090dd822
https://doi.org/10.1016/s1046-5928(02)00001-3

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Structural and Mechanistic Insights into Gating of K2P Channels

Autor: Thomas Baukrowitz, Niels Decher, Hariolf Fritzenschaft, Mark S.P. Sansom, Paula L. Piechotta, Murali K. Bollepalli, Gunter Ehrlich, Philip J. Stansfeld, Markus Rapedius, Isabelle Andres-Enguix, Stephen J. Tucker

Publikováno v: BIOPHYSICAL JOURNAL. 102(3)

Two-pore domain (K2P) potassium channels are important regulators of cellular electrical excitability and are capable of integrating a wide range of signalling pathways. However, the structure of these channels and their gating mechanism, in particul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d70e9ab08c633b752634d7aaad4b1d5
http://ora.ox.ac.uk/objects/uuid:c95e3cb0-5ecd-4cd8-b849-425e2ece8f05

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The pore structure and gating mechanism of K2P channels

Autor: Paula L. Piechotta, Stephen J. Tucker, Thomas Baukrowitz, Phillip J. Stansfeld, Murali K. Bollepalli, Gunter Ehrlich, Hariolf Fritzenschaft, Niels Decher, Isabelle Andres-Enguix, Mark S.P. Sansom, Markus Rapedius

Two-pore domain (K2P) potassium channels are important regulators of cellular electrical excitability. However, the structure of these channels and their gating mechanism, in particular the role of the bundle-crossing gate, are not well understood. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41a8ff50036ff4cfba0509036468bf1
https://europepmc.org/articles/PMC3230381/

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The pore structure and gating mechanism of K2P channels

Autor: Paula L, Piechotta, Markus, Rapedius, Phillip J, Stansfeld, Murali K, Bollepalli, Gunter, Ehrlich, Gunter, Erhlich, Isabelle, Andres-Enguix, Hariolf, Fritzenschaft, Niels, Decher, Mark S P, Sansom, Stephen J, Tucker, Thomas, Baukrowitz

Publikováno v: The EMBO Journal

The pore structure and gating mechanism of K2P channels K2P potassium channels are important regulators of cellular excitability. This study reveals that in contrast to most other K+ channels the primary gating mechanism in the K2P channel TREK-1 doe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::efef1c99f2b7e75c55caeb43beb27ecb
https://pubmed.ncbi.nlm.nih.gov/21822218

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Multiphoton FLIM and spectral imaging of cells and tissues

Autor: Karsten König, Volker Ulrich, Gunter Ehrlich, Peter Fischer, Iris Riemann

Publikováno v: Multiphoton Microscopy in the Biomedical Sciences IV.

Five-dimensional (5D) multiphoton measurements with submicron spatial resolution, 270 ps temporal resolution and 5 nm spectral resolution have been performed on living cells and tissues at 750 nm - 850 nm laser excitation. A compact (65x62x48 cm3) mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da74712273a991bf6b3a20b21922af02
https://doi.org/10.1117/12.528499

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Expression of Immunoregulatory Cytokines by Recombinant Coxsackievirus B3 Variants Confers Protection against Virus-Caused Myocarditis

Autor: Axel Stelzner, Andreas Henke, Gunter Ehrlich, Roland Zell

Clinical and laboratory investigations have demonstrated the involvement of viruses and bacteria as potential causative agents in cardiovascular disease and have specifically found coxsackievirus B3 (CVB3) to be a leading cause. Experimental data ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1f29f3506acc4deae50a6e85880d25
https://europepmc.org/articles/PMC115063/

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Studying the Influence of the Subunit Arrangement on the Function of Heterotetrameric Olfactory CNG Channels

Autor: Klaus Benndorf, Vasilica Nache, Jana Schirmeyer, Gunter Ehrlich, Thomas Zimmer

Publikováno v: Biophysical Journal. (2):290a

Cyclic nucleotide-gated (CNG) ion channels, key components in the sensory transduction of vision and odour, are non-selective cation channels, activated by the binding of cAMP or cGMP. Native CNG channels of olfactory sensory neurons are heterotetram

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