Thermodynamic profile of mutual subunit control in a heteromeric receptor

Autor: Eckhard Schulz, Michele Bonus, Christian Sattler, Thomas Zimmer, Melanie Wiegand, Ralf Schmauder, Klaus Benndorf, Nisa Kosmalla, Holger Gohlke, Taulant Kukaj, Thomas Eick, Gunter Ehrlich, Tina Schwabe, Jan L. Münch, Jana Schirmeyer, Sabine Hummert

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(30), e2100469118 (2021). doi:10.1073/pnas.2100469118

Significance Membrane receptors control innumerous essential functions of living cells and are proven drug targets for pharmacological interventions. Many receptors are composed of a number of subunits and contain multiple binding sites for ligands,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958ee041afd71a562ab3c4251498b6ca
http://europepmc.org/articles/PMC8325370

Overlapping and distinct roles for PI3Kβ and γ isoforms in S1P-induced migration of human and mouse endothelial cells

Autor: Sherry N Hsieh, Qing Chang, Peter J Kuhlencordt, Gunter Ehrlich, Regine Heller, Klaus T. Preissner, Simone M. Schoenwaelder, Reinhard Wetzker, Emilio Hirsch

Publikováno v: Cardiovascular Research. 80:96-105

Sphingosine-1-phosphate (S1P), a key regulator of vascular homeostasis and angiogenesis, promotes endothelial cell migration via stimulation of phosphoinositide 3-kinase (PI3K). The aim of this study was to identify the role of PI3Kbeta and gamma iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d8d82efe3b8232e5b9e08ee16d94aa
https://doi.org/10.1093/cvr/cvn159

Structural and Mechanistic Insights into Gating of K2P Channels

Autor: Thomas Baukrowitz, Niels Decher, Hariolf Fritzenschaft, Mark S.P. Sansom, Paula L. Piechotta, Murali K. Bollepalli, Gunter Ehrlich, Philip J. Stansfeld, Markus Rapedius, Isabelle Andres-Enguix, Stephen J. Tucker

Publikováno v: BIOPHYSICAL JOURNAL. 102(3)

Two-pore domain (K2P) potassium channels are important regulators of cellular electrical excitability and are capable of integrating a wide range of signalling pathways. However, the structure of these channels and their gating mechanism, in particul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d70e9ab08c633b752634d7aaad4b1d5
http://ora.ox.ac.uk/objects/uuid:c95e3cb0-5ecd-4cd8-b849-425e2ece8f05

The pore structure and gating mechanism of K2P channels

Autor: Paula L, Piechotta, Markus, Rapedius, Phillip J, Stansfeld, Murali K, Bollepalli, Gunter, Ehrlich, Gunter, Erhlich, Isabelle, Andres-Enguix, Hariolf, Fritzenschaft, Niels, Decher, Mark S P, Sansom, Stephen J, Tucker, Thomas, Baukrowitz

Publikováno v: The EMBO Journal

The pore structure and gating mechanism of K2P channels K2P potassium channels are important regulators of cellular excitability. This study reveals that in contrast to most other K+ channels the primary gating mechanism in the K2P channel TREK-1 doe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::efef1c99f2b7e75c55caeb43beb27ecb
https://pubmed.ncbi.nlm.nih.gov/21822218

Expression of Immunoregulatory Cytokines by Recombinant Coxsackievirus B3 Variants Confers Protection against Virus-Caused Myocarditis

Autor: Axel Stelzner, Andreas Henke, Gunter Ehrlich, Roland Zell

Clinical and laboratory investigations have demonstrated the involvement of viruses and bacteria as potential causative agents in cardiovascular disease and have specifically found coxsackievirus B3 (CVB3) to be a leading cause. Experimental data ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1f29f3506acc4deae50a6e85880d25
https://europepmc.org/articles/PMC115063/