Výsledky vyhledávání - "Gunter, Rappl"

Akademický článek

Comparison of the enzymatic efficiency of Liberase TM and tumor dissociation enzyme: effect on the viability of cells digested from fresh and cryopreserved human ovarian cortex

Autor: Viola Maria Schmidt, Vladimir Isachenko, Gunter Rappl, Gohar Rahimi, Bettina Hanstein, Bernd Morgenstern, Peter Mallmann, Evgenia Isachenko

Publikováno v: Reproductive Biology and Endocrinology, Vol 16, Iss 1, Pp 1-14 (2018)

Abstract Background The aim of this study was to examine the effectiveness of Tumor Dissociation Enzyme (TDE) on the viability of follicles after digestion of fresh and cryopreserved ovarian cortex fragments (OCFs). Methods Fresh and thawed OCF from

Externí odkaz: https://doaj.org/article/9b64acb7c5924e1abbb46c2ac27194df

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Akademický článek

Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance

Autor: Elaine Xu, Mafalda M. A. Pereira, Ismene Karakasilioti, Sebastian Theurich, Mona Al-Maarri, Gunter Rappl, Ari Waisman, F. Thomas Wunderlich, Jens C. Brüning

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)

Interleukin-6 (IL-6) is increased in obesity and activates T cells to promote inflammation. Here, Xuet al. use mice that lack IL-6 receptors on T cells to uncover the temporal and tissue-specific effects of classic and trans IL-6 signalling on inflam

Externí odkaz: https://doaj.org/article/03626f789b1e44eea8f9d27820e6c468

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IL12 integrated into the CAR exodomain converts CD8+ T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors

Autor: Hinrich Abken, Markus Chmielewski, Markus Barden, Lisa Hannappel, Andreas Hombach, Gunter Rappl, Agapios Sachinidis

Publikováno v: Molecular Therapy. 30:593-605

Chimeric antigen receptor (CAR)-redirected T cell therapy often fails to control tumors in the long term due to selecting cancer cells that downregulated or lost CAR targeted antigen. To reprogram the functional capacities specifically of engineered

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfb4e09ae73b30ad97dad8d9ae4f0fc6
https://doi.org/10.1016/j.ymthe.2021.10.011

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Germline C1GALT1C1 Mutation Causes a Multisystemic Chaperonopathy with Global Deficiency of Core 1-derived O-Glycosylation

The galactosyltransferase T-synthase exclusively synthesizes the T-antigen, a ubiquitous Oglycan core structure. Its function is dependent on its specific molecular chaperone, Cosmc (C1GALT1C1). In two maternal half-brothers with developmental delay,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9af0cd83c115ccff4b2ac95995a5df15
https://doi.org/10.21203/rs.3.rs-1716400/v1

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Noncanonical effector functions of the T-memory–like T-PLL cell are shaped by cooperative TCL1A and TCR signaling

Publikováno v: Blood. 136:2786-2802

T-cell prolymphocytic leukemia (T-PLL) is a poor-prognostic neoplasm. Differentiation stage and immune-effector functions of the underlying tumor cell are insufficiently characterized. Constitutive activation of the T-cell leukemia 1A (TCL1A) oncogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af64ce39db685c4e812b3f0cf2c9e2b
https://doi.org/10.1182/blood.2019003348

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Akademický článek

PECAM1(+)/Sca1(+)/CD38(+) vascular cells transform into myofibroblast-like cells in skin wound repair.

Autor: Julia Etich, Vera Bergmeier, Christian Frie, Sandra Kreft, Lena Bengestrate, Sabine Eming, Cornelia Mauch, Beate Eckes, Hikmet Ulus, Frances E Lund, Gunter Rappl, Hinrich Abken, Mats Paulsson, Bent Brachvogel

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e53262 (2013)

Skin injury induces the formation of new blood vessels by activating the vasculature in order to restore tissue homeostasis. Vascular cells may also differentiate into matrix-secreting contractile myofibroblasts to promote wound closure. Here, we cha

Externí odkaz: https://doaj.org/article/c701b6905739460c9a7918665f80248f

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IL12 integrated into the CAR exodomain converts CD8

Autor: Andreas, Hombach, Markus, Barden, Lisa, Hannappel, Markus, Chmielewski, Gunter, Rappl, Agapios, Sachinidis, Hinrich, Abken

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 30(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3309a305b147326865752686f20d0fd5
https://pubmed.ncbi.nlm.nih.gov/34678512

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Akademický článek

A proteomic view at T cell costimulation.

Autor: Rudolf Lichtenfels, Gunter Rappl, Andreas A Hombach, Christian V Recktenwald, Sven P Dressler, Hinrich Abken, Barbara Seliger

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e32994 (2012)

The "two-signal paradigm" in T cell activation predicts that the cooperation of "signal 1," provided by the T cell receptor (TCR) through engagement of major histocompatility complex (MHC)-presented peptide, with "signal 2″ provided by costimulator

Externí odkaz: https://doaj.org/article/f15381e356fe4abd9692c874411232ca

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Akademický článek

The CD3-zeta chimeric antigen receptor overcomes TCR Hypo-responsiveness of human terminal late-stage T cells.

Autor: Gunter Rappl, Tobias Riet, Sabine Awerkiew, Annette Schmidt, Andreas A Hombach, Herbert Pfister, Hinrich Abken

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e30713 (2012)

Adoptive therapy of malignant diseases with tumor-specific cytotoxic T cells showed remarkable efficacy in recent trials. Repetitive T cell receptor (TCR) engagement of target antigen, however, inevitably ends up in hypo-responsive cells with termina

Externí odkaz: https://doaj.org/article/da5a56470f014785bbd744c32b96c36d

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