Zobrazeno 1 - 10 of 94 pro vyhledávání: '"Gunnel Halldén"'
1
Akademický článek
Targeting Triple Negative Breast Cancer With Oncolytic Adenoviruses
Autor: Gabriela Green-Tripp, Callum Nattress, Gunnel Halldén
Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)
Breast cancer (BC) is the most common cancer globally, accounting for 685,000 deaths in 2020. Triple-negative breast cancers (TNBC) lack oestrogen (ER) and progesterone (PR) hormone receptor expression and HER2 overexpression. TNBC represent 10–15%
Externí odkaz: https://doaj.org/article/a6a6299947d9487c9b3d7a624f70b52e
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2
Akademický článek
HDAC Inhibitors Enhance Efficacy of the Oncolytic Adenoviruses Ad∆∆ and Ad-3∆-A20T in Pancreatic and Triple-Negative Breast Cancer Models
Autor: María Del Carmen Rodríguez Rodríguez, Inés García Rodríguez, Callum Nattress, Ahad Qureshi, Gunnel Halldén
Publikováno v: Viruses, Vol 14, Iss 5, p 1006 (2022)
The prognosis for triple-negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC) is dismal. TNBC and PDAC are highly aggressive cancers with few treatment options and a potential for rapid resistance to standard-of-care chemotherape
Externí odkaz: https://doaj.org/article/07313f0eea0046f2819c8b9c4f819263
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3
Data from Oncolytic Adenoviral Mutants with E1B19K Gene Deletions Enhance Gemcitabine-induced Apoptosis in Pancreatic Carcinoma Cells and Anti-Tumor Efficacy In vivo
Autor: Gunnel Halldén, Nick R. Lemoine, Enrique Miranda, Derek Davies, Daniel Öberg, Katrina Sweeney, Stephan Leitner
Purpose: Pancreatic adenocarcinoma is a rapidly progressive malignancy that is highly resistant to current chemotherapeutic modalities and almost uniformly fatal. We show that a novel targeting strategy combining oncolytic adenoviral mutants with the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc5029746fc668de01fcb8e38d1b7c1
https://doi.org/10.1158/1078-0432.c.6517719
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6
Data from Improved Potency and Selectivity of an Oncolytic E1ACR2 and E1B19K Deleted Adenoviral Mutant in Prostate and Pancreatic Cancers
Autor: Gunnel Halldén, Nick R. Lemoine, Celina Costas, Katrina Sweeney, Virginie Adam, Eva Yanover, Daniel Öberg
Purpose: Replication-selective oncolytic adenoviruses are a promising class of tumor-targeting agents with proven safety in hundreds of patients. However, clinical responses have been limited and viral mutants with higher potency are needed. Here, we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62986b4e64218274d34d45126f478a11
https://doi.org/10.1158/1078-0432.c.6517690.v1
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7
Complexing the Oncolytic Adenoviruses Ad∆∆ and Ad-3∆-A20T with Cationic Nanoparticles Enhances Viral Infection and Spread in Prostate and Pancreatic Cancer Models
Autor: Yang Kee Stella Man, Carmen Aguirre-Hernandez, Adrian Fernandez, Pilar Martin-Duque, Rebeca González-Pastor, Gunnel Halldén
Publikováno v: International journal of molecular sciences. 23(16)
Oncolytic adenoviruses (OAd) can be employed to efficiently eliminate cancer cells through multiple mechanisms of action including cell lysis and immune activation. Our OAds, AdΔΔ and Ad-3∆-A20T, selectively infect, replicate in, and kill adenoca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39e49b61060197b61ba3fc682f7b8f1
https://pubmed.ncbi.nlm.nih.gov/36012152
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8
Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer
Autor: Elisabete Carapuça, Y. K. Stella Man, Julie Foster, Gunnel Halldén, Alan L. Parker, James A. Davies, Jane K. Sosabowski
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Early phase clinical trials have demonstrated good therapeutic index for oncolytic adenoviruses in patients with solid tumours when administered intratumorally, resulting in local tumour elimination. Entrapment and binding of adenovirus to erythrocyt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1453c6dd1bd2e32841116951e92d4e99
http://link.springer.com/article/10.1038/s41598-019-49150-9
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9
Coating an adenovirus with functionalized gold nanoparticles favors uptake, intracellular trafficking and anti-cancer therapeutic efficacy
Autor: Y. K. Stella Man, Jesús M. de la Fuente, Rebeca González-Pastor, Yulan Hernandez, Gunnel Halldén, Marina Gimeno, Alba de Martino, Pilar Martin-Duque, Miguel Quintanilla
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Adenoviral (Ad) vectors have proven to be important tools for gene and cell therapy, although some issues still need to be addressed, such as undesired interactions with blood components and off-target sequestration that ultimately hamper efficacy. I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b3f06800342c57e417b5ff18e4edb6
http://hdl.handle.net/10261/264883
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10
Akademický článek
Adenovirus-mediated sensitization to the cytotoxic drugs docetaxel and mitoxantrone is dependent on regulatory domains in the E1ACR1 gene-region.
Autor: Enrique Miranda, Hector Maya Pineda, Daniel Öberg, Gioia Cherubini, Zita Garate, Nick R Lemoine, Gunnel Halldén
Publikováno v: PLoS ONE, Vol 7, Iss 10, p e46617 (2012)
Oncolytic adenoviruses have shown promising efficacy in clinical trials targeting prostate cancers that frequently develop resistance to all current therapies. The replication-selective mutants AdΔΔ and dl922-947, defective in pRb-binding, have bee
Externí odkaz: https://doaj.org/article/a3cecce52b2349eab6e0859e5b5b5795
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