Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gunnar Yngman"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 2, Pp 149-160 (2022)
Abstract The full random‐effects model (FREM) is a method for determining covariate effects in mixed‐effects models. Covariates are modeled as random variables, described by mean and variance. The method captures the covariate effects in estimate
Externí odkaz:
https://doaj.org/article/cfdd6f37365e48f9b90e4f2ed76ad75a
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics
The inclusion of covariates in population models during drug development is a key step to understanding drug variability and support dosage regimen proposal, but high correlation among covariates often complicates the identification of the true covar
Autor:
Gunnar Yngman, Elin M. Svensson, Mats O. Karlsson, Helen McIlleron, Maria C. Kjellsson, Paolo Denti
Fixed-dose combination formulations where several drugs are included in one tablet are important for the implementation of many long-term multidrug therapies. The selection of optimal dose ratios and tablet content of a fixed-dose combination and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9d219519896e01e09a294626e6add3
https://europepmc.org/articles/PMC7050562/
https://europepmc.org/articles/PMC7050562/
Autor:
Mats O. Karlsson, Maciej J. Swat, Richard Kaye, Andrea Mari, Marc Lavielle, Natallia Kokash, Niklas Hartung, Elisa Borella, Chris Muselle, Kajsa Harling, Lorenzo Pasotti, Letizia Carrara, Mike K. Smith, Roberto Bizzotto, Stuart L. Moodie, Nadia Terranova, Giulia Lestini, Maria L. Sardu, Emmanuelle Comets, Charlotte Kloft, Andrew C. Hooker, Gunnar Yngman, Paolo Magni, Henrik Bjugård Nyberg, Zinnia P. Parra-Guillen, Rikard Nordgren, Marylore Chenel, Eric Blaudez, Nicholas H. G. Holford, Ronald Gieschke, Florent Yvon, Gareth R. Smith, Phylinda L. S. Chan, Lutz Harnisch, Niels Rode-Kristensen
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 6:647-650
Recent work on Model Informed Drug Discovery and Development (MID3) has noted the need for clarity in model description used in quantitative disciplines such as pharmacology and statistics. 1-3 Cur ...
Autor:
Suresh Kankanwadi, Chayan Acharya, Andrew C. Hooker, Gunnar Yngman, Elodie L. Plan, Luis Lopez-Lazaro, Ari Brekkan, Mats O. Karlsson
Neutropenia and febrile neutropenia (FN) are serious side effects of cytotoxic chemotherapy which may be alleviated with the administration of recombinant granulocyte colony-stimulating factor (GCSF) derivatives, such as pegfilgrastim (PG) which incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2c17ab578916a46c2d03e67524a351
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-362482
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-362482
Autor:
Mats O. Karlsson, Gunnar Yngman, Paolo Denti, Elin M. Svensson, Helen McIlleron, Maria C. Kjellsson
Publikováno v:
Clinical Pharmacokinetics, 57, 5, pp. 591-599
Clinical Pharmacokinetics, 57, 591-599
Web of Science
Clinical Pharmacokinetics
Clinical Pharmacokinetics, 57, 591-599
Web of Science
Clinical Pharmacokinetics
Background and Objectives Fixed-dose combination formulations where several drugs are included in one tablet are important for the implementation of many long-term multidrug therapies. The selection of optimal dose ratios and tablet content of a fixe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125c830db7b583d33edb8bd910c17e36
https://hdl.handle.net/2066/191057
https://hdl.handle.net/2066/191057