Výsledky vyhledávání - "Gunnar W Reginsson"

A large-scale genome-wide association study meta-analysis of cannabis use disorder

Autor: Emma C Johnson, Ditte Demontis, Thorgeir E Thorgeirsson, Raymond K Walters, Renato Polimanti, Alexander S Hatoum, Sandra Sanchez-Roige, Sarah E Paul, Frank R Wendt, Toni-Kim Clarke, Dongbing Lai, Gunnar W Reginsson, Hang Zhou, June He, David A A Baranger, Daniel F Gudbjartsson, Robbee Wedow, Daniel E Adkins, Amy E Adkins, Jeffry Alexander, Silviu-Alin Bacanu, Tim B Bigdeli, Joseph Boden, Sandra A Brown, Kathleen K Bucholz, Jonas Bybjerg-Grauholm, Robin P Corley, Louisa Degenhardt, Danielle M Dick, Benjamin W Domingue, Louis Fox, Alison M Goate, Scott D Gordon, Laura M Hack, Dana B Hancock, Sarah M Hartz, Ian B Hickie, David M Hougaard, Kenneth Krauter, Penelope A Lind, Jeanette N McClintick, Matthew B McQueen, Jacquelyn L Meyers, Grant W Montgomery, Ole Mors, Preben B Mortensen, Merete Nordentoft, John F Pearson, Roseann E Peterson, Maureen D Reynolds, John P Rice, Valgerdur Runarsdottir, Nancy L Saccone, Richard Sherva, Judy L Silberg, Ralph E Tarter, Thorarinn Tyrfingsson, Tamara L Wall, Bradley T Webb, Thomas Werge, Leah Wetherill, Margaret J Wright, Stephanie Zellers, Mark J Adams, Laura J Bierut, Jason D Boardman, William E Copeland, Lindsay A Farrer, Tatiana M Foroud, Nathan A Gillespie, Richard A Grucza, Kathleen Mullan Harris, Andrew C Heath, Victor Hesselbrock, John K Hewitt, Christian J Hopfer, John Horwood, William G Iacono, Eric O Johnson, Kenneth S Kendler, Martin A Kennedy, Henry R Kranzler, Pamela A F Madden, Hermine H Maes, Brion S Maher, Nicholas G Martin, Matthew McGue, Andrew M McIntosh, Sarah E Medland, Elliot C Nelson, Bernice Porjesz, Brien P Riley, Michael C Stallings, Michael M Vanyukov, Scott Vrieze, Lea K Davis, Ryan Bogdan, Joel Gelernter, Howard J Edenberg, Kari Stefansson, Anders D Børglum, Arpana Agrawal, Raymond Walters, Emma Johnson, Jeanette McClintick, Alexander Hatoum, Frank Wendt, Mark Adams, Amy Adkins, Fazil Aliev, Anthony Batzler, Sarah Bertelsen, Joanna Biernacka, Tim Bigdeli, Li-Shiun Chen, Yi-Ling Chou, Franziska Degenhardt, Anna Docherty, Alexis Edwards, Pierre Fontanillas, Jerome Foo, Josef Frank, Ina Giegling, Scott Gordon, Laura Hack, Annette Hartmann, Sarah Hartz, Stefanie Heilmann-Heimbach, Stefan Herms, Colin Hodgkinson, Per Hoffman, Jouke Hottenga, Martin Kennedy, Mervi Alanne-Kinnunen, Bettina Konte, Jari Lahti, Marius Lahti-Pulkkinen, Lannie Ligthart, Anu Loukola, Brion Maher, Hamdi Mbarek, Andrew McIntosh, Matthew McQueen, Jacquelyn Meyers, Yuri Milaneschi, Teemu Palviainen, John Pearson, Roseann Peterson, Samuli Ripatti, Euijung Ryu, Nancy Saccone, Jessica Salvatore, Melanie Schwandt, Fabian Streit, Jana Strohmaier, Nathaniel Thomas, Jen-Chyong Wang, Bradley Webb, Amanda Wills, Jason Boardman, Danfeng Chen, Doo-Sup Choi, William Copeland, Robert Culverhouse, Norbert Dahmen, Benjamin Domingue, Sarah Elson, Mark Frye, Wolfgang Gäbel, Caroline Hayward, Marcus Ising, Margaret Keyes, Falk Kiefer, John Kramer, Samuel Kuperman, Susanne Lucae, Michael Lynskey, Wolfgang Maier, Karl Mann, Satu Männistö, Bertram Müller-Myhsok, Alison Murray, John Nurnberger, Aarno Palotie, Ulrich Preuss, Katri Räikkönen, Maureen Reynolds, Monika Ridinger, Norbert Scherbaum, Marc Schuckit, Michael Soyka, Jens Treutlein, Stephanie Witt, Norbert Wodarz, Peter Zill, Daniel Adkins, Dorret Boomsma, Laura Bierut, Sandra Brown, Kathleen Bucholz, Sven Cichon, E. Jane Costello, Harriet de Wit, Nancy Diazgranados, Danielle Dick, Johan Eriksson, Lindsay Farrer, Tatiana Foroud, Nathan Gillespie, Alison Goate, David Goldman, Richard Grucza, Dana Hancock, Andrew Heath, John Hewitt, Christian Hopfer, William Iacono, Eric Johnson, Jaakko Kaprio, Victor Karpyak, Kenneth Kendler, Henry Kranzler, Paul Lichtenstein, Penelope Lind, Matt McGue, James MacKillop, Pamela Madden, Hermine Maes, Patrik Magnusson, Nicholas Martin, Sarah Medland, Grant Montgomery, Elliot Nelson, Markus Nöthen, Abraham Palmer, Nancy Pederson, Brenda Penninx, John Rice, Marcella Rietschel, Brien Riley, Richard Rose, Dan Rujescu, Pei-Hong Shen, Judy Silberg, Michael Stallings, Ralph Tarter, Michael Vanyukov, Tamara Wall, John Whitfield, Hongyu Zhao, Benjamin Neale, Howard Edenberg

Publikováno v: Johnson, E, Hottenga, J, Ligthart, L, Mbarek, H, Milaneschi, Y, Boomsma, D, Agrawal, A & Psychiatric Genomics Consortium Substance Use Disorders Workgroup 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
Johnson, E C, Demontis, D, Thorgeirsson, T E, Walters, R K, Polimanti, R, Hatoum, A S, Sanchez-Roige, S, Paul, S E, Wendt, F R, Clarke, T-K, Lai, D, Reginsson, G W, Zhou, H, He, J, Baranger, D A A, Gudbjartsson, D F, Wedow, R, Adkins, D E, Adkins, A E, Alexander, J, Bacanu, S-A, Bigdeli, T B, Boden, J, Brown, S A, Bucholz, K K, Bybjerg-Grauholm, J, Corley, R P, Degenhardt, L, Dick, D M, Domingue, B W, Fox, L, Goate, A M, Gordon, S D, Hack, L M, Hancock, D B, Hartz, S M, Hickie, I B, Hougaard, D M, Krauter, K, Lind, P A, McClintick, J N, McQueen, M B, Meyers, J L, Montgomery, G W, Mors, O, Mortensen, P B, Nordentoft, M, Pearson, J F, Peterson, R E, Børglum, A D & Psychiatric Genomics Consortium Substance Use Disorders Workgroup 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
The Lancet Psychiatry, 7(12), 1032-1045. Elsevier Limited
The Lancet. Psychiatry
Johnson, E C, Demontis, D, Thorgeirsson, T E, Walters, R, Polimanti, R, Hatoum, A S, Sanchez-roige, S, Paul, S E, Wendt, F R, Clarke, T, Lai, D, Reginsson, G W, Zhou, H, He, J, Baranger, D A A, Gudbjartsson, D F, Wedow, R, Adkins, D, Adkins, A, Alexander, J, Bacanu, S, Bigdeli, T B, Boden, J, Brown, S A, Bucholz, K, Bybjerg-grauholm, J, Corley, R P, Degenhardt, L, Dick, D, Domingue, B, Fox, L, Goate, A M, Gordon, S, Hack, L, Hancock, D, Hartz, S, Hickie, I B, Hougaard, D M, Krauter, K, Lind, P, Mcclintick, J, Mcqueen, M, Meyers, J, Montgomery, G, Mors, O, Mortensen, P B, Nordentoft, M, Pearson, J F, Peterson, R, Reynolds, M, Rice, J, Runarsdottir, V, Saccone, N, Sherva, R, Silberg, J L, Tarter, R, Tyrfingsson, T, Wall, T, Webb, B, Werge, T, Wetherill, L, Wright, M J, Zellers, S, Adams, M J, Bierut, L, Boardman, J, Copeland, W, Farrer, L, Foroud, T M, Gillespie, N A, Grucza, R A, Harris, K M, Heath, A, Hesselbrock, V, Hewitt, J, Hopfer, C, Horwood, J, Iacono, W G, Johnson, E, Kendler, K, Kennedy, M, Kranzler, H, Madden, P A F, Maes, H, Maher, B, Martin, N G, Mcgue, M, Mcintosh, A M, Medland, S, Nelson, E C, Porjesz, B, Riley, B, Stallings, M, Vanyukov, M, Vrieze, S, Davis, L K, Bogdan, R, Gelernter, J, Edenberg, H, Stefansson, K, Børglum, A D, Agrawal, A, Walters, R, Polimanti, R, Johnson, E, Mcclintick, J, Hatoum, A, He, J, Wendt, F, Zhou, H, Adkins, A, Aliev, F, Bacanu, S, Batzler, A, Bertelsen, S, Biernacka, J, Bigdeli, T, Chen, L, Clarke, T, Chou, Y, Degenhardt, F, Docherty, A, Edwards, A, Fontanillas, P, Foo, J, Fox, L, Frank, J, Giegling, I, Gordon, S, Hack, L, Hartmann, A, Hartz, S, Heilmann-heimbach, S, Herms, S, Hodgkinson, C, Hoffman, P, Hottenga, J, Kennedy, M, Alanne-kinnunen, M, Konte, B, Lahti, J, Lahti-pulkkinen, M, Lai, D, Ligthart, L, Loukola, A, Maher, B, Mbarek, H, Mcintosh, A M, Mcqueen, M, Meyers, J, Milaneschi, Y, Palviainen, T, Pearson, J, Peterson, R, Ripatti, S, Ryu, E, Saccone, N, Salvatore, J, Sanchez-roige, S, Schwandt, M, Sherva, R, Streit, F, Strohmaier, J, Thomas, N, Wang, J, Webb, B, Wedow, R, Wetherill, L, Wills, A, Boardman, J, Chen, D, Choi, D, Copeland, W, Culverhouse, R, Dahmen, N, Degenhardt, L, Domingue, B, Elson, S, Frye, M, Gäbel, W, Hayward, C, Ising, M, Keyes, M, Kiefer, F, Kramer, J, Kuperman, S, Lucae, S, Lynskey, M, Maier, W, Mann, K, Männistö, S, Müller-myhsok, B, Murray, A, Nurnberger, J, Palotie, A, Preuss, U, Räikkönen, K, Reynolds, M, Ridinger, M, Scherbaum, N, Schuckit, M, Soyka, M, Treutlein, J, Witt, S, Wodarz, N, Zill, P, Adkins, D, Boden, J, Boomsma, D, Bierut, L, Brown, S, Bucholz, K, Cichon, S, Costello, E J, De Wit, H, Diazgranados, N, Dick, D, Eriksson, J, Farrer, L, Foroud, T, Gillespie, N, Goate, A, Goldman, D, Grucza, R, Hancock, D, Harris, K M, Heath, A, Hesselbrock, V, Hewitt, J, Hopfer, C, Horwood, J, Iacono, W, Johnson, E, Kaprio, J, Karpyak, V, Kendler, K, Kranzler, H, Krauter, K, Lichtenstein, P, Lind, P, Mcgue, M, Mackillop, J, Madden, P, Maes, H, Magnusson, P, Martin, N, Medland, S, Montgomery, G, Nelson, E, Nöthen, M, Palmer, A, Pederson, N, Penninx, B, Porjesz, B, Rice, J, Rietschel, M, Riley, B, Rose, R, Rujescu, D, Shen, P, Silberg, J, Stallings, M, Tarter, R, Vanyukov, M, Vrieze, S, Wall, T, Whitfield, J, Zhao, H, Neale, B, Gelernter, J, Edenberg, H & Agrawal, A 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
Johnson, E C, Demontis, D, Thorgeirsson, T E, Walters, R K, Polimanti, R, Hatoum, A S, Sanchez-Roige, S, Paul, S E, Wendt, F R, Clarke, T K, Lai, D, Reginsson, G W, Zhou, H, He, J, Baranger, D A A, Gudbjartsson, D F, Wedow, R, Adkins, D E, Adkins, A E, Alexander, J, Bacanu, S A, Bigdeli, T B, Boden, J, Brown, S A, Bucholz, K K, Bybjerg-Grauholm, J, Corley, R P, Degenhardt, L, Dick, D M, Domingue, B W, Fox, L, Goate, A M, Gordon, S D, Hack, L M, Hancock, D B, Hartz, S M, Hickie, I B, Hougaard, D M, Krauter, K, Lind, P A, McClintick, J N, McQueen, M B, Meyers, J L, Montgomery, G W, Mors, O, Mortensen, P B, Nordentoft, M, Pearson, J F, Peterson, R E, Werge, T & Psychiatric Genomics Consortium Substance Use Disorders Workgroup 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
Psychiatric Genomics Consortium Substance Use Disorders Workgroup 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
The Lancet Psychiatry

Background: Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50–70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the s

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https://doi.org/10.1016/s2215-0366(20)30339-4

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Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence

Publikováno v: Molecular Psychiatry, 23
Hancock, D B, Guo, Y, Reginsson, G W, Gaddis, N C, Lutz, S M, Sherva, R, Loukola, A, Minica, C C, Markunas, C A, Han, Y, Young, K A, Gudbjartsson, D F, Gu, F, McNeil, D W, Qaiser, B, Glasheen, C, Olson, S, Landi, M T, Madden, P A F, Farrer, L A, Vink, J, Saccone, N L, Neale, M C, Kranzler, H R, McKay, J, Hung, R J, Amos, C I, Marazita, M L, Boomsma, D I, Baker, T B, Gelernter, J, Kaprio, J, Caporaso, N E, Thorgeirsson, T E, Hokanson, J E, Bierut, L J, Stefansson, K & Johnson, E O 2018, ' Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence ', Molecular Psychiatry, vol. 23, no. 9, pp. 1911–1919 . https://doi.org/10.1038/mp.2017.193
Molecular Psychiatry, 23, 9
Molecular Psychiatry, 23(9). Nature Publishing Group

Item does not contain fulltext Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with sequence var

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https://doi.org/10.1038/mp.2017.193

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Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction

Autor: Thorgeir E. Thorgeirsson, Sigurgeir Olafsson, Hogni Oskarsson, Jack Euesden, Daniel F. Gudbjartsson, Hreinn Stefansson, Valgerdur Runarsdottir, Gyda Bjornsdottir, Thorarinn Tyrfingsson, Engilbert Sigurdsson, Ingunn Hansdottir, Andres Ingason, Kari Stefansson, Stacy Steinberg, Gunnar W Reginsson

Publikováno v: Addiction Biology. 23:485-492

We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 1

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https://doi.org/10.1111/adb.12496

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Genome-wide association study implicates CHRNA2 in cannabis use disorder

Publikováno v: Nature Neuroscience
Demontis, D, Rajagopal, V M, Thorgeirsson, T E, Als, T D, Grove, J, Leppälä, K, Gudbjartsson, D F, Pallesen, J, Hjorthøj, C, Reginsson, G W, Tyrfingsson, T, Runarsdottir, V, Qvist, P, Christensen, J H, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Huckins, L M, Stahl, E A, Timmermann, A, Agerbo, E, Hougaard, D M, Werge, T, Mors, O, Mortensen, P B, Nordentoft, M, Daly, M J, Stefansson, H, Stefansson, K, Nyegaard, M & Børglum, A D 2019, ' Genome-wide association study implicates CHRNA2 in cannabis use disorder ' Nature Neuroscience . https://doi.org/10.1038/s41593-019-0416-1
Demontis, D, Rajagopal, V M, Thorgeirsson, T E, Als, T D, Grove, J, Leppälä, K, Gudbjartsson, D F, Pallesen, J, Hjorthøj, C, Reginsson, G W, Tyrfingsson, T, Runarsdottir, V, Qvist, P, Christensen, J H, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Huckins, L M, Stahl, E A, Timmermann, A, Agerbo, E, Hougaard, D M, Werge, T, Mors, O, Mortensen, P B, Nordentoft, M, Daly, M J, Stefansson, H, Stefansson, K, Nyegaard, M & Børglum, A D 2019, ' Genome-wide association study implicates CHRNA2 in cannabis use disorder ', Nature Neuroscience, vol. 22, no. 7, pp. 1066-1074 . https://doi.org/10.1038/s41593-019-0416-1
Nat Neurosci
Demontis, D, Rajagopal, V M, Thorgeirsson, T E, Als, T D, Grove, J, Leppälä, K, Gudbjartsson, D F, Pallesen, J, Hjorthøj, C, Reginsson, G W, Tyrfingsson, T, Runarsdottir, V, Qvist, P, Christensen, J H, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Huckins, L M, Stahl, E A, Timmermann, A, Agerbo, E, Hougaard, D M, Werge, T, Mors, O, Mortensen, P B, Nordentoft, M, Daly, M J, Stefansson, H, Stefansson, K, Nyegaard, M & Børglum, A D 2019, ' Genome-wide association study implicates CHRNA2 in cannabis use disorder ', Nature Neuroscience, vol. 22, pp. 1066-1074 . https://doi.org/10.1038/s41593-019-0416-1

Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%.

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Genome-wide association study implicates CHRNA2 in cannabis use disorder

Introductory paragraphCannabis is the most frequently used illicit psychoactive substance worldwide1. Life time use has been reported among 35-40% of adults in Denmark2 and the United States3. Cannabis use is increasing in the population4–6 and amo

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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

Autor: Thomas Muley, Younghun Han, Xuchen Zong, Philip Lazarus, Wim Timens, Melinda C. Aldrich, Nancy Diao, Dakai Zhu, Christopher A. Haiman, Shanbeh Zienolddiny, Jennifer A. Doherty, Ming-Sound Tsao, Xiangjun Xiao, John K. Field, Judith Manz, Demetrios Albanes, Olle Melander, Sara Lindstroem, Jakob S Johansen, Li Su, Ruyang Zhang, Xia Jiang, Geoffrey Liu, Thorgeir E. Thorgeirsson, Milica Kontic, Natasha B. Leighl, Kim Overvad, Albert Rosenberger, Bin Zhu, Ciprian Bolca, James D. McKay, Irene Brüske, Woon-Puay Koh, David C. Christiani, Lynne R. Wilkens, Yu-Tang Gao, Georgia Chenevix-Trench, María Soler Artigas, Vidar Skaug, Aage Haugen, M. Dawn Teare, Yonathan Brhane, Margaret R. Spitz, Eric O. Johnson, Guillermo Fernández-Tardón, H-Erich Wichmann, Maxime Lamontagne, Victoria L. Stevens, Kari Stefansson, Juncheng Dai, Pier Alberto Bertazzi, Gary E. Goodman, Stephen Lam, Louise V. Wain, Stephen J. Chanock, Gunnar W Reginsson, Karen A. Pooley, Ana Fernández-Somoano, Penella J. Woll, Thorunn Rafnar, Mikael Johansson, Yun Chul Hong, Rachel F. Tyndale, Maria Teresa Landi, Jonathan Beesley, Eric J. Duell, Lambertus A. Kiemeney, Simona Ognjanovic, Matthew B. Schabath, Yuanqing Ye, Jinyoung Byun, Michael P.A. Davies, Loic Le Marchand, Xifeng Wu, John McLaughlin, Gad Rennert, Jonas Manjer, Richard S. Houlston, Susanne M. Arnold, Hongbing Shen, Neil E. Caporaso, Lesley M. Butler, Sharon M. Lutz, Rayjean J. Hung, Frances A. Shepherd, David C. Muller, Angeline S. Andrew, Michael W. Marcus, Zhibin Hu, David Zaridze, Paul Brennan, Rosario Tumino, Jin Hee Kim, Eric B. Haura, Matt P Barnett, David C. Nickle, Tadeusz M Orlowski, Per Bakke, Antonia Trichopoulou, Anders Mellemgaard, Claudio W. Pikielny, Alison M. Dunning, Beata Swiatkowska, Angela Cecilia Pesatori, Kjell Grankvist, Yafang Li, Vladimir Janout, Walid Saliba, Lei Song, Dana B. Hancock, Ahsan Kamal, Ghislaine Scelo, William S. Bush, Jolanta Lissowska, Anush Mukeria, Yohan Bossé, Heike Bickeböller, Robert Carreras-Torres, Nathan C. Gaddis, Ivana Holcatova, Fiona Taylor, Laura J. Bierut, Xuemei Ji, Angela Cox, Mattias Johansson, Jian-Min Yuan, David C. Qian, Stig E. Bojesen, Adonina Tardón, Martin D. Tobin, Linda Kachuri, Hans Brunnström, Henricus F. M. van der Heijden, Chu Chen, Angela Risch, Maria Timofeeva, Fangyi Gu, Christopher I. Amos, Ma'en Obeidat, Philippe Joubert

Publikováno v: Nature Genetics, 49(7), 1126-+. Nature Publishing Group
Nature Genetics, 49, 7, pp. 1126-1132
Nature genetics
Nature Genetics
Dipòsit Digital de la UB
Universidad de Barcelona
Nat. Genet. 49, 1126-1132 (2017)
Nature Genetics, 49, 1126-1132
Recercat. Dipósit de la Recerca de Catalunya
instname
McKay, J D, Hung, R J, Han, Y, Zong, X, Carreras-Torres, R, Christiani, D C, Caporaso, N E, Johansson, M, Xiao, X, Li, Y, Byun, J, Dunning, A, Pooley, K A, Qian, D C, Ji, X, Liu, G, Timofeeva, M N, Bojesen, S E, Wu, X, Le Marchand, L, Albanes, D, Bickeböller, H, Aldrich, M C, Bush, W S, Tardón, A, Rennert, G, Teare, M D, Field, J K, Kiemeney, L A, Lazarus, P, Haugen, A, Lam, S T, Schabath, M B, Andrew, A S, Shen, H, Hong, Y-C, Yuan, J-M, Bertazzi, P A, Pesatori, A C, Ye, Y, Diao, N, Su, L, Zhang, R, Brhane, Y, Leighl, N, Johansen, J S, Mellemgaard, A, Saliba, W, Overvad, K, Johansson, M & SpiroMeta Consortium 2017, ' Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes ', Nature Genetics, vol. 49, no. 7, pp. 1126-+ . https://doi.org/10.1038/ng.3892
McKay, J D, Hung, R J, Han, Y, Zong, X, Carreras-Torres, R, Christiani, D C, Caporaso, N E, Johansson, M, Xiao, X, Li, Y, Byun, J, Dunning, A, Pooley, K A, Qian, D C, Ji, X, Liu, G, Timofeeva, M N, Bojesen, S E, Wu, X, Marchand, L L, Albanes, D, Bickeböller, H, Aldrich, M C, Bush, W S, Tardon, A, Rennert, G, Teare, M D, Field, J K, Kiemeney, L A, Lazarus, P, Haugen, A, Lam, S, Schabath, M B, Andrew, A S, Shen, H, Hong, Y C, Yuan, J M, Bertazzi, P A, Pesatori, A C, Ye, Y, Diao, N, Su, L, Zhang, R, Brhane, Y, Leighl, N, Johansen, J S, Mellemgaard, A, Saliba, W, Haiman, C A, Wilkens, L R, SpiroMeta Consortium, Rafnar, T, Thorgeirsson, T E, Reginsson, G W, Brennan, P, Landi, M T & Amos, C I 2017, ' Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes ', Nature Genetics, vol. 49, no. 7, pp. 1126-1132 . https://doi.org/10.1038/ng.3892

Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing

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https://research.rug.nl/en/publications/e35fc3ad-9855-4894-a338-7333b0b96769

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A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences

Publikováno v: Molecular Psychiatry, 21, 5, pp. 594-600
Molecular Psychiatry, 21, 594-600
Molecular Psychiatry
Thorgeirsson, T E, Steinberg, S, Reginsson, G W, Bjornsdottir, G, Rafnar, T, Jonsdottir, I, Helgadóttir, Á, Gretarsdottir, S, Helgadottir, H, Jonsson, S, Matthiasson, S E, Gislason, T, Tyrfingsson, T, Gudbjartsson, T, Isaksson, H J, Hardardottir, H, Sigvaldason, A, Kiemeney, L A, Haugen, A, Zienolddiny, S, Wolf, H J, Franklin, W A, Panadero, A, Mayordomo, J I, Hall, I P, Rönmark, E, Lundb'ck, B, Dirksen, A, Ashraf, H, Pedersen, J J H, Masson, G, Sulem, P, Thorsteinsdottir, U, Gudbjartsson, D F & Stefansson, K 2016, ' A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences ', Molecular Psychiatry, vol. 21, no. 5, pp. 594-600 . https://doi.org/10.1038/mp.2016.13

Contains fulltext : 172466.pdf (Publisher’s version ) (Open Access) Using Icelandic whole-genome sequence data and an imputation approach we searched for rare sequence variants in CHRNA4 and tested them for association with nicotine dependence. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa5be8e2285977cae1c10307c6b9e3a
https://doi.org/10.1038/mp.2016.13

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W-band PELDOR with 1 kW microwave power: Molecular geometry, flexibility and exchange coupling

Autor: P.A.S. Cruickshank, David R. Bolton, Graham Smith, Olav Schiemann, Robert I. Hunter, Snorri Th. Sigurdsson, Gunnar W. Reginsson

Publikováno v: Journal of Magnetic Resonance. 216:175-182

A technique that is increasingly being used to determine the structure and conformational flexibility of biomacromolecules is Pulsed Electron–Electron Double Resonance (PELDOR or DEER), an Electron Paramagnetic Resonance (EPR) based technique. At X

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ea2a63bcb755cab9e99dc96db4f525
https://doi.org/10.1016/j.jmr.2012.01.019

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Studying biomolecular complexes with pulsed electron–electron double resonance spectroscopy

Autor: Gunnar W. Reginsson, Olav Schiemann

Publikováno v: Biochemical Society Transactions. 39:128-139

The function of biomolecules is intrinsically linked to their structure and the complexes they form during function. Techniques for the determination of structures and dynamics of these nanometre assemblies are therefore important for an understandin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6fff31951d03a8c50513d25d75bb65
https://doi.org/10.1042/bst0390128

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Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional spectroscopic probe Ç

Autor: Thomas E. Edwards, Olav Schiemann, Snorri Th. Sigurdsson, Sandip A. Shelke, Gunnar W. Reginsson, Adrian R. Ferré-D'Amaré, Pavol Cekan

Publikováno v: Nucleic Acids Research

Electron Paramagnetic Resonance (EPR) spectroscopy and fluorescence spectroscopy are complementary biophysical techniques used to examine the structure and dynamics of macromolecules. We have previously described the bi-functional spectroscopic probe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7412d5286178d499f626bb18389d008
http://europepmc.org/articles/PMC3105401

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