Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Gunnar Schotta"'
Autor:
Zhiqi Sun, Filippo M. Cernilogar, Helena Horvatic, Assa Yeroslaviz, Zeinab Abdullah, Gunnar Schotta, Veit Hornung
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113322- (2023)
Summary: Fibrosis, characterized by sustained activation of myofibroblasts and excessive extracellular matrix (ECM) deposition, is known to be associated with chronic inflammation. Receptor-interacting protein kinase 3 (RIPK3), the central kinase of
Externí odkaz:
https://doaj.org/article/8a12caf9c5604b6ab7e0d6ecc9a72dba
Autor:
Zeyang Wang, Rui Fan, Angela Russo, Filippo M. Cernilogar, Alexander Nuber, Silvia Schirge, Irina Shcherbakova, Iva Dzhilyanova, Enes Ugur, Tobias Anton, Lisa Richter, Heinrich Leonhardt, Heiko Lickert, Gunnar Schotta
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Silencing of endogenous retroviruses is crucial for maintaining transcriptional and genomic integrity of cells and is maintained by histone H3K9 methylation and/or DNA methylation in various cell types. Here the authors show that loss of DNA methyltr
Externí odkaz:
https://doaj.org/article/78b50c5c99874d8abc10ec64817c03eb
Autor:
Graeme J. Thorn, Christopher T. Clarkson, Anne Rademacher, Hulkar Mamayusupova, Gunnar Schotta, Karsten Rippe, Vladimir B. Teif
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The ability to predict epigenetic regulation is an important challenge in biology. Here the authors describe heterochromatin nanodomains (HNDs) and compare four different types of H3K9me2/3-marked HNDs in mouse embryonic stem cells. They further deve
Externí odkaz:
https://doaj.org/article/eba452e3535d4b96a475fb542898533b
Autor:
Sophia Groh, Anna Viktoria Milton, Lisa Katherina Marinelli, Cara V. Sickinger, Angela Russo, Heike Bollig, Gustavo Pereira de Almeida, Andreas Schmidt, Ignasi Forné, Axel Imhof, Gunnar Schotta
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Endogenous retroviruses (ERVs) compose a significant portion of mammalian genomes; however, how ERVs are regulated is not well known. Here the authors performed a genome-wide sgRNA screen to identify Morc3 as a mediator of ERV silencing. They show Mo
Externí odkaz:
https://doaj.org/article/7babdca1f6d949e89f3a1f776c0144b2
Autor:
Sara Lago, Matteo Nadai, Filippo M. Cernilogar, Maryam Kazerani, Helena Domíniguez Moreno, Gunnar Schotta, Sara N. Richter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
G-quadruplex (G4) structures play complex roles linked to transcription regulation. Here the authors, by comparing G4 location and transcript levels in liposarcoma and keratinocyte cells, reveal that G4s cooperate with transcription factors to determ
Externí odkaz:
https://doaj.org/article/dd1811100f074ec8a3558e9cc0a6bb45
Autor:
Julia M. Kempf, Sabrina Weser, Michael D. Bartoschek, Klaus H. Metzeler, Binje Vick, Tobias Herold, Kerstin Völse, Raphael Mattes, Manuela Scholz, Lucas E. Wange, Moreno Festini, Enes Ugur, Maike Roas, Oliver Weigert, Sebastian Bultmann, Heinrich Leonhardt, Gunnar Schotta, Wolfgang Hiddemann, Irmela Jeremias, Karsten Spiekermann
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Chemotherapy resistance is the main impediment in the treatment of acute myeloid leukaemia (AML). Despite rapid advances, the various mechanisms inducing resistance development remain to be defined in detail. Here we report that loss-of-func
Externí odkaz:
https://doaj.org/article/0a2238e6e69947ba9113af2e76fa12bb
Autor:
Nikos E. Papaioannou, Natallia Salei, Stephan Rambichler, Kaushikk Ravi, Jelena Popovic, Vanessa Küntzel, Christian H. K. Lehmann, Remi Fiancette, Johanna Salvermoser, Dominika W. Gajdasik, Ramona Mettler, Denise Messerer, Joana Carrelha, Caspar Ohnmacht, Dirk Haller, Ralf Stumm, Tobias Straub, Sten Eirik W. Jacobsen, Christian Schulz, David R. Withers, Gunnar Schotta, Diana Dudziak, Barbara U. Schraml
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear. Here the authors show, using fate-mapping and single-cell RNA sequencing, that neonatal cD
Externí odkaz:
https://doaj.org/article/41e3849697dd487fb5c3e7640b8e444b
Autor:
Masami Shiimori, Yu Ichida, Ryota Nukiwa, Toshie Sakuma, Haruka Abe, Rei Kajitani, Yuji Fujino, Akira Kikuchi, Takeshi Kawamura, Tatsuhiko Kodama, Shinichi Toyooka, Katsuhiko Shirahige, Gunnar Schotta, Keiji Kuba, Takehiko Itoh, Yumiko Imai
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102660- (2021)
Summary: The spatial organization of chromatin is known to be highly dynamic in response to environmental stress. However, it remains unknown how chromatin dynamics contributes to or modulates disease pathogenesis. Here, we show that upon influenza v
Externí odkaz:
https://doaj.org/article/8ceceb1c8a2846ce930ebc4b749fab3d
Autor:
Xianming Wang, Michael Sterr, Ansarullah, Ingo Burtscher, Anika Böttcher, Julia Beckenbauer, Johanna Siehler, Thomas Meitinger, Hans-Ulrich Häring, Harald Staiger, Filippo M. Cernilogar, Gunnar Schotta, Martin Irmler, Johannes Beckers, Christopher V.E. Wright, Mostafa Bakhti, Heiko Lickert
Publikováno v:
Molecular Metabolism, Vol 24, Iss , Pp 80-97 (2019)
Objective: Hundreds of missense mutations in the coding region of PDX1 exist; however, if these mutations predispose to diabetes mellitus is unknown. Methods: In this study, we screened a large cohort of subjects with increased risk for diabetes and
Externí odkaz:
https://doaj.org/article/38c7550f0463430bba653e3eba240c45
Autor:
Xianming Wang, Michael Sterr, Ingo Burtscher, Shen Chen, Anja Hieronimus, Fausto Machicao, Harald Staiger, Hans-Ulrich Häring, Gabriele Lederer, Thomas Meitinger, Filippo M. Cernilogar, Gunnar Schotta, Martin Irmler, Johannes Beckers, Martin Hrabě de Angelis, Michael Ray, Christopher V.E. Wright, Mostafa Bakhti, Heiko Lickert
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 57-68 (2018)
Objective: Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor (TF) PDX1 leads to pancreatic agenesis, whereas heterozygous mutations can cause Maturity-Onset Diabetes of the Young 4 (MODY4). Although the fu
Externí odkaz:
https://doaj.org/article/1191a257d4294ce78a3966838b2d29b0