Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Gunnar Ratsch"'
Publikováno v:
IEEE Access, Vol 9, Pp 76750-76758 (2021)
Kernel methods on discrete domains have shown great promise for many challenging data types, for instance, biological sequence data and molecular structure data. Scalable kernel methods like Support Vector Machines may offer good predictive performan
Externí odkaz:
https://doaj.org/article/17301ebe09ad40fcaa8ede50eda636c1
Autor:
Rebekka Wegmann, Ximena Bonilla, Ruben Casanova, Stéphane Chevrier, Ricardo Coelho, Cinzia Esposito, Joanna Ficek-Pascual, Sandra Goetze, Gabriele Gut, Francis Jacob, Andrea Jacobs, Jack Kuipers, Ulrike Lischetti, Julien Mena, Emanuela S. Milani, Michael Prummer, Jacobo Sarabia Del Castillo, Franziska Singer, Sujana Sivapatham, Nora C. Toussaint, Oliver Vilinovszki, Mattheus H. E. Wildschut, Tharshika Thavayogarajah, Disha Malani, The TumorProfiler Consortium, Rudolf Aebersold, Marina Bacac, Niko Beerenwinkel, Christian Beisel, Bernd Bodenmiller, Viola Heinzelmann-Schwarz, Viktor H. Koelzer, Mitchell P. Levesque, Holger Moch, Lucas Pelkmans, Gunnar Rätsch, Markus Tolnay, Andreas Wicki, Bernd Wollscheid, Markus G. Manz, Berend Snijder, Alexandre P. A. Theocharides
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Deep single-cell multi-omic profiling offers a promising approach to understand and overcome drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML). Here, we combine single-cell ex vivo drug profiling (pharmacoscopy) wit
Externí odkaz:
https://doaj.org/article/d909919fc46044dd87b6ffb2a1e8a194
Autor:
Shkurta Gashi, Pietro Oldrati, Max Moebus, Marc Hilty, Liliana Barrios, Firat Ozdemir, PHRT Consortium, Veronika Kana, Andreas Lutterotti, Gunnar Rätsch, Christian Holz
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Multiple sclerosis (MS) is a neurological disease of the central nervous system that is the leading cause of non-traumatic disability in young adults. Clinical laboratory tests and neuroimaging studies are the standard methods to diagnose an
Externí odkaz:
https://doaj.org/article/85057b2a37ad466fb1194689e9ebb632
Autor:
Patrik Simmler, Eleonora I Ioannidi, Tamara Mengis, Kim Fabiano Marquart, Simran Asawa, Kjong Van-Lehmann, Andre Kahles, Tinu Thomas, Cornelia Schwerdel, Nicola Aceto, Gunnar Rätsch, Markus Stoffel, Gerald Schwank
Publikováno v:
eLife, Vol 12 (2023)
The splicing factor SF3B1 is recurrently mutated in various tumors, including pancreatic ductal adenocarcinoma (PDAC). The impact of the hotspot mutation SF3B1K700E on the PDAC pathogenesis, however, remains elusive. Here, we demonstrate that Sf3b1K7
Externí odkaz:
https://doaj.org/article/60ac28afd80545779ac04224dc960954
Autor:
Olga Mineeva, Daniel Danciu, Bernhard Schölkopf, Ruth E Ley, Gunnar Rätsch, Nicholas D Youngblut
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 5, p e1011001 (2023)
The number of published metagenome assemblies is rapidly growing due to advances in sequencing technologies. However, sequencing errors, variable coverage, repetitive genomic regions, and other factors can produce misassemblies, which are challenging
Externí odkaz:
https://doaj.org/article/3da1308b99c642dfbd9b7c8030f366a2
Autor:
Wenguang Shao, Tiannan Guo, Nora C. Toussaint, Peng Xue, Ulrich Wagner, Li Li, Konstantina Charmpi, Yi Zhu, Jianmin Wu, Marija Buljan, Rui Sun, Dorothea Rutishauser, Thomas Hermanns, Christian Daniel Fankhauser, Cedric Poyet, Jelena Ljubicic, Niels Rupp, Jan H. Rüschoff, Qing Zhong, Andreas Beyer, Jiafu Ji, Ben C. Collins, Yansheng Liu, Gunnar Rätsch, Peter J. Wild, Ruedi Aebersold
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Protein degradation in clinical samples is largely unexplored. Here, the authors analyze the transcriptome and proteome of clinical tissue samples and develop an algorithm to assess protein degradation, showing that protein degradation is negligible
Externí odkaz:
https://doaj.org/article/5e2fad9e30374816bb16c6dcb2619e1f
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 1, p e1008400 (2021)
Tumors contain multiple subpopulations of genetically distinct cancer cells. Reconstructing their evolutionary history can improve our understanding of how cancers develop and respond to treatment. Subclonal reconstruction methods cluster mutations i
Externí odkaz:
https://doaj.org/article/2e2c7a038087427aaf69ce77002b06e4
Autor:
Melissa S Cline, Rachel G Liao, Michael T Parsons, Benedict Paten, Faisal Alquaddoomi, Antonis Antoniou, Samantha Baxter, Larry Brody, Robert Cook-Deegan, Amy Coffin, Fergus J Couch, Brian Craft, Robert Currie, Chloe C Dlott, Lena Dolman, Johan T den Dunnen, Stephanie O M Dyke, Susan M Domchek, Douglas Easton, Zachary Fischmann, William D Foulkes, Judy Garber, David Goldgar, Mary J Goldman, Peter Goodhand, Steven Harrison, David Haussler, Kazuto Kato, Bartha Knoppers, Charles Markello, Robert Nussbaum, Kenneth Offit, Sharon E Plon, Jem Rashbass, Heidi L Rehm, Mark Robson, Wendy S Rubinstein, Dominique Stoppa-Lyonnet, Sean Tavtigian, Adrian Thorogood, Can Zhang, Marc Zimmermann, BRCA Challenge Authors, John Burn, Stephen Chanock, Gunnar Rätsch, Amanda B Spurdle
Publikováno v:
PLoS Genetics, Vol 14, Iss 12, p e1007752 (2018)
The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly collaborative research activities. Its goal is to generate an informed and
Externí odkaz:
https://doaj.org/article/3d040669de2049168c109d5c746eac9a
Autor:
Konstantinos Loupasakis, David Kuo, Upneet K Sokhi, Christopher Sohn, Bethany Syracuse, Eugenia G Giannopoulou, Sung Ho Park, Hyelim Kang, Gunnar Rätsch, Lionel B Ivashkiv, George D Kalliolias
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0179762 (2017)
During rheumatoid arthritis (RA), Tumor Necrosis Factor (TNF) activates fibroblast-like synoviocytes (FLS) inducing in a temporal order a constellation of genes, which perpetuate synovial inflammation. Although the molecular mechanisms regulating TNF
Externí odkaz:
https://doaj.org/article/fc2e2852a93d4ad5bf6d724ad55ed4d1
Autor:
Manu J Dubin, Pei Zhang, Dazhe Meng, Marie-Stanislas Remigereau, Edward J Osborne, Francesco Paolo Casale, Philipp Drewe, André Kahles, Geraldine Jean, Bjarni Vilhjálmsson, Joanna Jagoda, Selen Irez, Viktor Voronin, Qiang Song, Quan Long, Gunnar Rätsch, Oliver Stegle, Richard M Clark, Magnus Nordborg
Publikováno v:
eLife, Vol 4 (2015)
Epigenome modulation potentially provides a mechanism for organisms to adapt, within and between generations. However, neither the extent to which this occurs, nor the mechanisms involved are known. Here we investigate DNA methylation variation in Sw
Externí odkaz:
https://doaj.org/article/7a81a64f8f274f49b75689528b7d5fb6