Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Gunnar P.H. Dietz"'
Autor:
Thorsten R. Doeppner, Mimount El Aanbouri, Gunnar P.H. Dietz, Jens Weise, Sönke Schwarting, Mathias Bähr
Publikováno v:
Neurobiology of Disease, Vol 40, Iss 1, Pp 265-276 (2010)
Neural precursor cells (NPC) are an interesting tool in experimental stroke research, but their therapeutic potential is limited due to poor long-term survival. We therefore in vitro transduced subventricular zone-(SVZ)-derived NPC with the anti-apop
Externí odkaz:
https://doaj.org/article/0b5e756f16d7433596399b9ee833312f
Publikováno v:
Pharmaceuticals, Vol 3, Iss 4, Pp 1232-1240 (2010)
Cdk5 is essential for neuronal differentiation processes in the brain. Activation of Cdk5 requires the association with the mostly neuron-specific p35 or p39. Overactivation of CDK5 by cleavage of p35 into p25 is thought to be involved in neurodegene
Externí odkaz:
https://doaj.org/article/4a981ab298bc4abba67191b8b18b2bc5
Autor:
Thorsten R. Doeppner, Gunnar P.H. Dietz, Mimount El Aanbouri, Joachim Gerber, Otto W. Witte, Mathias Bähr, Jens Weise
Publikováno v:
Neurobiology of Disease, Vol 34, Iss 1, Pp 87-94 (2009)
Cerebral ischemia activates endogenous neurogenesis in the subventricular zone (SVZ) and the dentate gyrus. Consecutively, SVZ-derived neural precursors migrate towards ischemic lesions. However, functional relevance of activated neurogenesis is limi
Externí odkaz:
https://doaj.org/article/fea6214f3ae44d4aa14fbcfdd281ace7
Autor:
Christelle Guégan, Jérôme Braudeau, Cécile Couriaud, Gunnar P.H. Dietz, Pierre Lacombe, Mathias Bähr, Marika Nosten-Bertrand, Brigitte Onténiente
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 1, Pp 177-186 (2006)
Caspases play a major role in the infarction process that follows occlusion of cerebral arteries and are important targets for stroke therapy. We have generated three fusion proteins that link various domains of the X chromosome-linked inhibitor of a
Externí odkaz:
https://doaj.org/article/74ea6864c67a4ad0a54a0c8b931d6f7a
Autor:
Ricarda Diem, Naimeh Taheri, Gunnar P.H. Dietz, Antje Kuhnert, Katharina Maier, Muriel B. Sättler, Ivana Gadjanski, Doron Merkler, Mathias Bähr
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 218-226 (2005)
In multiple sclerosis (MS), post-mortem studies of human brain tissue as well as data from animal models have shown that apoptosis of neurons occurs to a significant extent during this disease. As neurodegeneration in MS correlates with permanent neu
Externí odkaz:
https://doaj.org/article/3962a20bdb09457cab77daa7b5a00a7c
Publikováno v:
Molecular and cellular neurosciences. 116
Tinnitus is defined as the perception of sound in the absence of external acoustic stimuli. Frequent comorbidities or associated factors are depression, anxiety, concentration problems, insomnia, resignation, helplessness, headache, bruxism, or socia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5639d7c52beffe2630f7f1265308320
https://pubmed.ncbi.nlm.nih.gov/34560255
https://pubmed.ncbi.nlm.nih.gov/34560255
Publikováno v:
Brain and cognition. 154
Aged rodents have been used as preclinical models of age-associated cognitive decline. Most of those models displayed substantial impairments in learning and memory. The initial, more subtle changes that precede more severe losses in cognitive abilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0079ad375a4683d1b8b0b029d1911cbd
https://pubmed.ncbi.nlm.nih.gov/34543909
https://pubmed.ncbi.nlm.nih.gov/34543909
Autor:
Gunnar P.H. Dietz, Bernd L. Fiebich, Harsharan S. Bhatia, Brahim Gargouri, Johanna Carstensen, Michael Huell
Publikováno v:
Phytomedicine. 44:45-55
Background Neuroinflammation is a key factor of Alzheimer's disease (AD) and other neurodegenerative conditions. Microglia are the resident mononuclear immune cells of the central nervous system (CNS). They play an essential role in the maintenance o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db59f1e51bb6c0a04010ee1ec9d3b31
https://doi.org/10.1016/j.phymed.2018.04.009
https://doi.org/10.1016/j.phymed.2018.04.009
Publikováno v:
Cellular and Molecular Neurobiology
Sortilin was first identified based on its activity as part of intracellular protein sorting machinery. Recently, it was discovered that sortilin also acts as a cell surface receptor for the propeptide form of nerve growth factor (proNGF), progranuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d76982aa9e0d96206496ef4ddd50c27
http://europepmc.org/articles/PMC5882628
http://europepmc.org/articles/PMC5882628
Autor:
Gunnar P.H. Dietz, David E. Gloriam, Christoph Bisig, Vignir Isberg, Kirsten Andersen, Hans Bräuner-Osborne
Publikováno v:
Journal of Chemical Information and Modeling. 54:1553-1557
GPR139 is an orphan G protein-coupled receptor expressed mainly in the central nervous system. We developed a pharmacophore model based on known GPR139 surrogate agonists which led us to propose aromatic-containing dipeptides as potential ligands. Up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6b1c5eae44fa2399655b2001277e73
https://doi.org/10.1021/ci500197a
https://doi.org/10.1021/ci500197a