Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Gunnar M. Olsen"'
1
Augmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of α2- and α4-containing nicotinic acetylcholine receptors
Autor: Morten Grunnet, Philip K. Ahring, Kathy L. Kohlhaas, Tino Dyhring, Dan Peters, Smith M, Jeppe Kejser Christensen, Sandager-Nielsen K, Jacobsen Am, E.Ø. Nielsen, Daniel B. Timmermann, Gunnar M. Olsen
Publikováno v: British Journal of Pharmacology. 167:164-182
BACKGROUND AND PURPOSE Positive allosteric modulation of α4β2 nicotinic acetylcholine (nACh) receptors could add a new dimension to the pharmacology and therapeutic approach to these receptors. The novel modulator NS9283 was therefore tested extens
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a25a324fd3d11c452c08ab3afdec5aba
https://doi.org/10.1111/j.1476-5381.2012.01989.x
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2
Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors
Autor: William H. Bunnelle, Tino Dyhring, Jens Halvard Grønlien, David J. Anderson, Peter Curzon, John Malysz, Gunnar M. Olsen, Kirsten Thorin-Hagene, Clark A. Briggs, Paige Kerr, Hilde Ween, Murali Gopalakrishnan, Daniel B. Timmermann, Dan Peters
Publikováno v: British Journal of Pharmacology. 158:1486-1494
Background and purpose: Several agonists of the α7 nicotinic acetylcholine receptor (nAChR) have been developed for treatment of cognitive deficits. However, agonist efficacy in vivo is difficult to reconcile with rapid α7 nAChR desensitization in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e03e70550bb60426e0c0a2ef38dbb934
https://doi.org/10.1111/j.1476-5381.2009.00426.x
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3
An Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor Possessing Cognition-Enhancing Properties in Vivo
Autor: Daniel B, Timmermann, Jens Halvard, Grønlien, Kathy L, Kohlhaas, Elsebet Ø, Nielsen, Eva, Dam, Tino D, Jørgensen, Philip K, Ahring, Dan, Peters, Dorte, Holst, Jeppe K, Christensen, Jeppe K, Chrsitensen, John, Malysz, Clark A, Briggs, Murali, Gopalakrishnan, Gunnar M, Olsen
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 323:294-307
Augmentation of nicotinic alpha7 receptor function is considered to be a potential therapeutic strategy aimed at ameliorating cognitive and mnemonic dysfunction in relation to debilitating pathological conditions, such as Alzheimer's disease and schi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2e19ee44a779ae070e47722f0a55be
https://doi.org/10.1124/jpet.107.120436
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4
Synthesis of the serotonin transporter ligand (±)-10-methyl 3-[6-nitro-(2-quinolinyl)]-3,10-diazabicyclo-[4.3.1]-decane ([11C-methyl]NS 2495) and firstin vivoresults
Autor: Jørgen Scheel-Krüger, Dirk Bender, Hélène Audrain, Elsebet Ø. Nielsen, Dan Peters, Gunnar M. Olsen, Paul Cumming
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 46:873-882
The serotonin transporter ligand (±)-10-[11C]-methyl 3-[6-nitro-(2-quinolinyl)]-3,10-diazabicyclo-[4.3.1]-decane ([11C-methyl]NS 2495) was synthesized via a methylation reaction with [11C]methyl iodide. The radiochemical purity exceeded 99% and the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fe069e07a33ef84a02b5c512ddf7a81
https://doi.org/10.1002/jlcr.726
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5
[11C]-NS 4194 versus [11C]-DASB for PET imaging of serotonin transporters in living porcine brain
Autor: Steen Jakobsen, Gunnar M. Olsen, Nielsen Elsebet Ostergaard, Paul Cumming, Dan Peters, Alan A. Wilson, Dirk Bender, Donald F. Smith, Svend Borup Jensen, Jørgen Scheel-Krüger
Publikováno v: Synapse. 49:170-177
In vitro, the novel diazabicyclononane NS 4194 has several thousandfold selectivity for blocking the transport into rat brain synaptosomes of [ 3 H]-serotonin in comparison to [3H]-dopamine or [ 3 H]-noradrenaline. We have prepared [ 1 1 C]-NS 4194 i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b075fbf41ab92819aa7f3785b48e28af
https://doi.org/10.1002/syn.10222
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6
Synthesis of (±) 3-(6-nitro-2-quinolinyl)-[9-methyl-11C]-3,9-diazabicyclo-[4.2.1]-nonane ([11C-methyl]NS 4194)
Autor: Dirk Bender, Jørgen Scheel-Krüger, Donald F. Smith, Nielsen Elsebet Ostergaard, Svend Borup Jensen, Albert Gjedde, Dan Peters, Gunnar M. Olsen
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 45:181-189
(±) 3-(6-Nitro-2-quinolinyl)-[9-methyl-11C]-3,9-diazabicyclo-[4.2.1]-nonane ([11C-methyl]NS 4194), a selective serotonin reuptake inhibitor (SSRI), was synthesised within 35 min after end of bombardment with a radiochemical purity >98%. It had a dec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a1ca2db570ef3b2627aa8c1d4e076c4
https://doi.org/10.1002/jlcr.542
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7
Novel Potent Ligands for the Central Nicotinic Acetylcholine Receptor: Synthesis, Receptor Binding, and 3D-QSAR Analysis
Autor: Dan Peters, Tommy Liljefors, Gunnar M. Olsen, Elsebet Ø. Nielsen, Simon Feldbaek Nielsen
Publikováno v: Journal of Medicinal Chemistry. 43:2217-2226
In the past few years the focus on central acetylcholine receptors has shifted from compounds with affinity for muscarinic acetylcholine receptors (mAChR) to compounds with affinity for nicotinic acetylcholine receptors (nAChR). The therapeutic poten
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085ddd373d6e807ce59112aeecccd428
https://doi.org/10.1021/jm990973d
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8
A combined α7 nicotinic acetylcholine receptor agonist and monoamine reuptake inhibitor, NS9775, represents a novel profile with potential benefits in emotional and cognitive disturbances
Autor: Jeppe Kejser Christensen, Elsebet Ø. Nielsen, Dan Peters, Gunnar M. Olsen, Jesper T. Andreasen, John Paul Redrobe
Publikováno v: Neuropharmacology. 73
As affective and cognitive disturbances frequently co-occur in psychiatric disorders, research into opportunities to simultaneously target both entities is warranted. These disorders are typically treated with monoamine reuptake inhibitors (MRIs), wh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b2d22ba252c38c075445fc0f1e62c6c
https://pubmed.ncbi.nlm.nih.gov/23748055
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10
Subtype-selective nicotinic acetylcholine receptor agonists enhance the responsiveness to citalopram and reboxetine in the mouse forced swim test
Autor: John Paul Redrobe, Jesper T. Andreasen, Dan Peters, Jeppe Kejser Christensen, Elsebet Ø. Nielsen, Gunnar M. Olsen, Naheed R. Mirza
Publikováno v: Journal of psychopharmacology (Oxford, England). 25(10)
Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. Accordingly, nicotine enhances antidepressant-like actions of reuptake inhibitors selective for serotonin or noradrenaline in the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77200bb8d539709b75403912245ecd6
https://pubmed.ncbi.nlm.nih.gov/20360159
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