Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Gunnar Kleinau"'
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1120 (2024)
Functional melanocortin receptor (MCR) genes have been identified in the genomes of early chordates, e.g., the cyclostomata. Whether they appear in the most ancient chordates such as cephalochordate and urochordata, however, remains unclear due to mi
Externí odkaz:
https://doaj.org/article/3343c2ee530a41939e28ae19959a2861
Autor:
Larissa Anthofer, Philipp Gmach, Zeynep Cansu Uretmen Kagiali, Gunnar Kleinau, Jonas Rotter, Robert Opitz, Patrick Scheerer, Annette G. Beck-Sickinger, Philipp Wolf, Heike Biebermann, Ingo Bechmann, Peter Kühnen, Heiko Krude, Sarah Paisdzior
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7565 (2024)
The melanocortin-4 receptor (MC4R) is a key player in the hypothalamic leptin–melanocortin pathway that regulates satiety and hunger. MC4R belongs to the G protein-coupled receptors (GPCRs), which are known to form heterodimers with other membrane
Externí odkaz:
https://doaj.org/article/2964aa52c7284f949f6e5e974a754a48
Autor:
Gunnar Kleinau, Amal Hassan Ali, Franziska Wiechert, Michal Szczepek, Andrea Schmidt, Christian M.T. Spahn, Ines Liebscher, Torsten Schöneberg, Patrick Scheerer
Publikováno v:
Pharmacological Research, Vol 197, Iss , Pp 106971- (2023)
The class B2 of GPCRs known as adhesion G protein-coupled receptors (aGPCRs) has come under increasing academic and nonacademic research focus over the past decade due to their physiological importance as mechano-sensors in cell-cell and cell-matrix
Externí odkaz:
https://doaj.org/article/4bd3ee6180ce4632b09ce48a660071c3
Autor:
Yvonne Giesecke, Vahid Asimi, Valentina Stulberg, Gunnar Kleinau, Patrick Scheerer, Beate Koksch, Carsten Grötzinger
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15117 (2023)
G protein-coupled receptor 83 (GPR83) is a class A G protein-coupled receptor with predominant expression in the cerebellum and proposed function in the regulation of food intake and in anxiety-like behavior. The neuropeptide PEN has been suggested a
Externí odkaz:
https://doaj.org/article/c9663ad51e7b401197465948a376948e
Autor:
Thomas Wallach, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny, Drew Adler, Yuanyuan Zhai, Victor Kumbol, Omar Dzaye, Jutta Schüler, Matthias Futschik, Rolf Backofen, Patrick Scheerer, Seija Lehnardt
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-24 (2021)
Abstract Background MicroRNA (miRNA) expression in the brain is altered in neurodegenerative diseases. Recent studies demonstrated that selected miRNAs conventionally regulating gene expression at the post-transcriptional level can act extracellularl
Externí odkaz:
https://doaj.org/article/61f971538f07412cba14e312e4335927
Autor:
Amadeus Samuel Schulze, Gunnar Kleinau, Rosanna Krakowsky, David Rochmann, Ranajit Das, Catherine L. Worth, Petra Krumbholz, Patrick Scheerer, Claudia Stäubert
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105087- (2022)
Summary: The G protein-coupled receptor 84 (GPR84) is found in immune cells and its expression is increased under inflammatory conditions. Activation of GPR84 by medium-chain fatty acids results in pro-inflammatory responses. Here, we screened availa
Externí odkaz:
https://doaj.org/article/9327fa6e680f4359b0498678101c4e36
Autor:
Junfeng Chen, Huijuan Bi, Mats E. Pettersson, Daiki X. Sato, Angela P. Fuentes-Pardo, Chunheng Mo, Shady Younis, Ola Wallerman, Patric Jern, Gregorio Molés, Ana Gómez, Gunnar Kleinau, Patrick Scheerer, Leif Andersson
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Junfeng Chen et al. examine potential functional consequences of reproduction timing-associated TSHR alleles segregating in Atlantic herring. By comparing fish that spawn during the spring to those that spawn in the autumn, they find that the spring-
Externí odkaz:
https://doaj.org/article/4c568d32a12445638dba01ae6f0f5cdf
Autor:
David Speck, Gunnar Kleinau, Michal Szczepek, Dennis Kwiatkowski, Rusan Catar, Aurélie Philippe, Patrick Scheerer
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
In conjunction with the endothelin (ET) type A (ETAR) and type B (ETBR) receptors, angiotensin (AT) type 1 (AT1R) and type 2 (AT2R) receptors, are peptide-binding class A G-protein-coupled receptors (GPCRs) acting in a physiologically overlapping con
Externí odkaz:
https://doaj.org/article/94f8faa97f714c0cbf09a0383af24758
Autor:
David Speck, Gunnar Kleinau, Mark Meininghaus, Antje Erbe, Alexandra Einfeldt, Michal Szczepek, Patrick Scheerer, Vera Pütter
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
G-protein coupled receptors (GPCR) transduce extracellular stimuli into the cell interior and are thus centrally involved in almost all physiological-neuronal processes. This essential function and association with many diseases or pathological condi
Externí odkaz:
https://doaj.org/article/a28adbaf73874fac9aa49bdca5b38ca8
Autor:
Aurélie Philippe, Gunnar Kleinau, Jason Jannis Gruner, Sumin Wu, Daniel Postpieszala, David Speck, Harald Heidecke, Simon J. Dowell, Gabriela Riemekasten, Peter W. Hildebrand, Julian Kamhieh-Milz, Rusan Catar, Michal Szczepek, Duska Dragun, Patrick Scheerer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3984 (2022)
The angiotensin II (Ang II) type 1 receptor (AT1R) is involved in the regulation of blood pressure (through vasoconstriction) and water and ion homeostasis (mediated by interaction with the endogenous agonist). AT1R can also be activated by auto-anti
Externí odkaz:
https://doaj.org/article/f84ca03ecdd34d1fa719d43bef9e7ba0