Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Gunnar K, Gouras"'
Autor:
Sonia George, Annica Rönnbäck, Gunnar K. Gouras, Géraldine H. Petit, Fiona Grueninger, Bengt Winblad, Caroline Graff, Patrik Brundin
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/58b662a6554f4f979652818fc4b7bcad
Autor:
Yuriy Pomeshchik, Erika Velasquez, Jeovanis Gil, Oxana Klementieva, Ritha Gidlöf, Marie Sydoff, Silvia Bagnoli, Benedetta Nacmias, Sandro Sorbi, Gunilla Westergren-Thorsson, Gunnar K. Gouras, Melinda Rezeli, Laurent Roybon
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract The hippocampus is a primary region affected in Alzheimer’s disease (AD). Because AD postmortem brain tissue is not available prior to symptomatic stage, we lack understanding of early cellular pathogenic mechanisms. To address this issue,
Externí odkaz:
https://doaj.org/article/2ae5b16d269b4929b5cc61c410c184d5
Autor:
Emelie Andersson, Nina Schultz, Takashi Saito, Takaomi C. Saido, Kaj Blennow, Gunnar K. Gouras, Henrik Zetterberg, Oskar Hansson
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background Aβ42/Aβ40 ratios in cerebrospinal fluid (CSF) and blood are reduced in preclinical Alzheimer’s disease (AD), but their temporal and correlative relationship with cerebral Aβ pathology at this early disease stage is not well u
Externí odkaz:
https://doaj.org/article/2583dc4d799c47f49b216a7fc4f14f50
Autor:
Rosalía Fernández-Calle, Sabine C. Konings, Javier Frontiñán-Rubio, Juan García-Revilla, Lluís Camprubí-Ferrer, Martina Svensson, Isak Martinson, Antonio Boza-Serrano, José Luís Venero, Henrietta M. Nielsen, Gunnar K. Gouras, Tomas Deierborg
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-47 (2022)
Abstract ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset
Externí odkaz:
https://doaj.org/article/9c0dd70d8975473bbafdc75e9c623ab4
Autor:
Laura Torres-Garcia, Joana M. P. Domingues, Edoardo Brandi, Caroline Haikal, Janitha M. Mudannayake, Inês C. Brás, Ellen Gerhardt, Wen Li, Alexander Svanbergsson, Tiago F. Outeiro, Gunnar K. Gouras, Jia-Yi Li
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Parkinson’s disease (PD) and Alzheimer’s disease (AD) are characterized by pathological accumulation and aggregation of different amyloidogenic proteins, α-synuclein (aSyn) in PD, and amyloid-β (Aβ) and Tau in AD. Strikingly, few PD a
Externí odkaz:
https://doaj.org/article/d99e8843f4304b3f85647c84f9bdbeaf
Autor:
Nadja Gustavsson, Agnes Paulus, Isak Martinsson, Anders Engdahl, Kadda Medjoubi, Konstantin Klementiev, Andrea Somogyi, Tomas Deierborg, Ferenc Borondics, Gunnar K. Gouras, Oxana Klementieva
Publikováno v:
Light: Science & Applications, Vol 10, Iss 1, Pp 1-10 (2021)
A new imaging approach that combines two techniques standing at the opposite ends of the electromagnetic spectrum.
Externí odkaz:
https://doaj.org/article/61e677167e5c4cef96afbbfe8f48218e
Autor:
Isak Martinsson, Luis Quintino, Megg G. Garcia, Sabine C. Konings, Laura Torres-Garcia, Alexander Svanbergsson, Oliver Stange, Rebecca England, Tomas Deierborg, Jia-Yi Li, Cecilia Lundberg, Gunnar K. Gouras
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer’s disease (AD) is increasingly seen as a disease of synapses and diverse evidence has implicated the amyloid-β peptide (Aβ) in synapse damage. The molecular and cellular mechanism(s) by which Aβ and/or its precursor protein, the amyloi
Externí odkaz:
https://doaj.org/article/ff57882822e84937998f1dfb99ae5e93
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Synaptic changes and neuronal network dysfunction are among the earliest changes in Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk factor in AD, has been shown to be present at synapses and to induce hyperexcitability i
Externí odkaz:
https://doaj.org/article/51c7ec8a161b4e74a2a3a0ac71c7c8bb
Autor:
Oxana Klementieva, Christophe Sandt, Isak Martinsson, Mustafa Kansiz, Gunnar K. Gouras, Ferenc Borondics
Publikováno v:
Advanced Science, Vol 7, Iss 6, Pp n/a-n/a (2020)
Abstract Loss of memory during Alzheimer's disease (AD), a fatal neurodegenerative disorder, is associated with neuronal loss and the aggregation of amyloid proteins into neurotoxic β‐sheet enriched structures. However, the mechanism of amyloid pr
Externí odkaz:
https://doaj.org/article/6f4c96060a044646880de3fb44564697
Publikováno v:
Neurobiology of Disease, Vol 113, Iss , Pp 1-10 (2018)
Alzheimer's disease (AD) brain tissue can act as a seed to accelerate aggregation of amyloid-β (Aβ) into plaques in AD transgenic mice. Aβ seeds have been hypothesized to accelerate plaque formation in a prion-like manner of templated seeding and
Externí odkaz:
https://doaj.org/article/c272164f982347e78bef57d271e27d3a