Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Gunnar Hedlund"'
Autor:
Meir Azulay, Michal Shahar, Eitan Shany, Eti Elbaz, Sveta Lifshits, Marie Törngren, Adam Friedmann, Robert Kramer, Gunnar Hedlund
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background Despite remarkable progress, the immunotherapies currently used in the clinic, such as immune checkpoint blockade (ICB) therapy, still have limited efficacy against many types of solid tumors. One major barrier to effective treatm
Externí odkaz:
https://doaj.org/article/54bd572181154e1994748f438bb9e68f
Autor:
Gunnar Hedlund, Helena Eriksson, Anette Sundstedt, Göran Forsberg, Bent K Jakobsen, Nicholas Pumphrey, Karin Rödström, Karin Lindkvist-Petersson, Per Björk
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e79082 (2013)
The T lymphocytes are the most important effector cells in immunotherapy of cancer. The conceptual objective for developing the tumor targeted superantigen (TTS) ABR-217620 (naptumomab estafenatox, 5T4Fab-SEA/E-120), now in phase 3 studies for advanc
Externí odkaz:
https://doaj.org/article/7714f2df1eeb429698d214d001f27ccb
Autor:
Timothy Eisen, Örjan Nordle, Goran Forsberg, Gunnar Hedlund, Rustem Khasanov, Oleg Karyakin, Petr Karlov, Igor Bondarenko, Serhii Polenkov, Mihai Harza, Tosho Ganev, Oleg Gladkov, Vladimir Bondar, Yaroslav Shparyk, Martin Gore, Robert E. Hawkins
Purpose: To prospectively determine the efficacy of naptumomab estafenatox (Nap) + IFNα versus IFN in metastatic renal cell carcinoma (RCC).Experimental Design: In a randomized, open-label, multicenter, phase II/III study, 513 patients with RCC rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32207290e588e558aa5fdbb5a6380aba
https://doi.org/10.1158/1078-0432.c.6523545.v1
https://doi.org/10.1158/1078-0432.c.6523545.v1
Autor:
Timothy Eisen, Örjan Nordle, Goran Forsberg, Gunnar Hedlund, Rustem Khasanov, Oleg Karyakin, Petr Karlov, Igor Bondarenko, Serhii Polenkov, Mihai Harza, Tosho Ganev, Oleg Gladkov, Vladimir Bondar, Yaroslav Shparyk, Martin Gore, Robert E. Hawkins
Cox regression analysis with interaction between baseline covariates and treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6468db6e39fda0878203f9bffcc2ae57
https://doi.org/10.1158/1078-0432.22457241.v1
https://doi.org/10.1158/1078-0432.22457241.v1
Autor:
Timothy Eisen, Örjan Nordle, Goran Forsberg, Gunnar Hedlund, Rustem Khasanov, Oleg Karyakin, Petr Karlov, Igor Bondarenko, Serhii Polenkov, Mihai Harza, Tosho Ganev, Oleg Gladkov, Vladimir Bondar, Yaroslav Shparyk, Martin Gore, Robert E. Hawkins
Anti-SEA/E-120 concentration in ITT and the subgroup SG at baseline and immediately before Nap cycle 2 (week 9), before Nap cycle 3 (week 17) and at week 25. Median{plus minus}SE is depicted.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d0d873a396743058269943cbaa358b
https://doi.org/10.1158/1078-0432.22457256
https://doi.org/10.1158/1078-0432.22457256
Autor:
Timothy Eisen, Örjan Nordle, Goran Forsberg, Gunnar Hedlund, Rustem Khasanov, Oleg Karyakin, Petr Karlov, Igor Bondarenko, Serhii Polenkov, Mihai Harza, Tosho Ganev, Oleg Gladkov, Vladimir Bondar, Yaroslav Shparyk, Martin Gore, Robert E. Hawkins
Overlapping anti-SEA/E-120 windows in Moving median and adapted Subpopulation Treatment Effect Pattern Plot (STEPP) analysis. Anti-SEA/E-120 by blocks where min, median and max values are depicted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6427280763ab96ad4a657a124f96ae
https://doi.org/10.1158/1078-0432.22457265
https://doi.org/10.1158/1078-0432.22457265
Autor:
Timothy Eisen, Örjan Nordle, Goran Forsberg, Gunnar Hedlund, Rustem Khasanov, Oleg Karyakin, Petr Karlov, Igor Bondarenko, Serhii Polenkov, Mihai Harza, Tosho Ganev, Oleg Gladkov, Vladimir Bondar, Yaroslav Shparyk, Martin Gore, Robert E. Hawkins
Anti-SEA/E-120 vs exposure of Nap. Concentration of Nap after Nap at day 1 of treatment. Moving median of 8 overlapping subgroups of patients with different baseline anti-SEA/E-120 (pmol/mL). Median{plus minus}SE is depicted.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f8f6a13b3a3a7cceaad1fce6213868
https://doi.org/10.1158/1078-0432.22457262
https://doi.org/10.1158/1078-0432.22457262
Autor:
Timothy Eisen, Örjan Nordle, Goran Forsberg, Gunnar Hedlund, Rustem Khasanov, Oleg Karyakin, Petr Karlov, Igor Bondarenko, Serhii Polenkov, Mihai Harza, Tosho Ganev, Oleg Gladkov, Vladimir Bondar, Yaroslav Shparyk, Martin Gore, Robert E. Hawkins
Anti-SEA/E-120 vs IL-2 day 1 3h. Concentration of induced IL-2 after Nap at day 1 of treatment. Moving median of 8 overlapping subgroups of patients with different baseline anti-SEA/E-120 (pmol/mL). Median{plus minus}SE is depicted.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5fa95bce3b6baf7231a1b2fc636d5d
https://doi.org/10.1158/1078-0432.22457250
https://doi.org/10.1158/1078-0432.22457250
Autor:
Timothy Eisen, Örjan Nordle, Goran Forsberg, Gunnar Hedlund, Rustem Khasanov, Oleg Karyakin, Petr Karlov, Igor Bondarenko, Serhii Polenkov, Mihai Harza, Tosho Ganev, Oleg Gladkov, Vladimir Bondar, Yaroslav Shparyk, Martin Gore, Robert E. Hawkins
Cytokine response after Nap treatment in ITT and the subgroup SG patients during cycle 1 (week 1), cycle 2 (week 9) and cycle 3 (week 17). IL-2 (A). IL-6 (B). IL-10 (C). IFN-ϒ (D). TNF-α (E). Geomean{plus minus}SE is depicted.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42330a8cb984c55e15501c45f94f5ba5
https://doi.org/10.1158/1078-0432.22457253.v1
https://doi.org/10.1158/1078-0432.22457253.v1
Autor:
Timothy Eisen, Örjan Nordle, Goran Forsberg, Gunnar Hedlund, Rustem Khasanov, Oleg Karyakin, Petr Karlov, Igor Bondarenko, Serhii Polenkov, Mihai Harza, Tosho Ganev, Oleg Gladkov, Vladimir Bondar, Yaroslav Shparyk, Martin Gore, Robert E. Hawkins
Cox regression analyses with three way interaction stratified by either MSKCC or HENG risk.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324b7e8c93d7bc3c8598160f40f572ad
https://doi.org/10.1158/1078-0432.22457244
https://doi.org/10.1158/1078-0432.22457244