Výsledky vyhledávání - "Gunnar Gronberg"

Metabolism of Strained Rings: Glutathione S-transferase–Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation

Autor: Lars Weidolf, Eva-Henriette Bangur, Gunnar Gronberg, Neal Castagnoli, Xue-Qing Li, Martin A. Hayes

Publikováno v: Drug Metabolism and Disposition. 47:1247-1256

AZD1979 [(3-(4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone] is a melanin-concentrating hormone receptor 1 antagonist designed for the treatment of obesity. In this study, metabolit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c21d815a7a1c575c7b5e54e0b467b739
https://doi.org/10.1124/dmd.119.088658

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Discovery of a Novel Microsomal Epoxide Hydrolase-Catalyzed Hydration of a Spiro Oxetane

Autor: Kristina Berggren, Lars Weidolf, Martin A. Hayes, Gunnar Gronberg, Neal Castagnoli, Xue-Qing Li

Publikováno v: Drug Metabolism and Disposition. 44:1341-1348

Oxetane moieties are increasingly being used by the pharmaceutical industry as building blocks in drug candidates because of their pronounced ability to improve physicochemical parameters and metabolic stability of drug candidates. The enzymes that c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7689e52373795731f1b36233b758fd91
https://doi.org/10.1124/dmd.116.071142

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