Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gunnar Ehrlich"'
Publikováno v:
Zeitschrift für Naturforschung B. 74:819-824
Knoevenagel reaction of pivaloylacetone with formaldehyde and subsequent aldol condensation ends up with 3-methyl-4,6-dipivaloylcyclohex-2-enone. The structure of the product is proved by an X-ray structure determination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fbeb292cc22d3c5d32bd5ecfb05030c
https://doi.org/10.1515/znb-2019-0115
https://doi.org/10.1515/znb-2019-0115
Autor:
Gunnar Ehrlich, Christian B. W. Stark
Publikováno v:
The Journal of organic chemistry. 84(6)
The cytospolides are a novel group of fungal secondary metabolites first described in 2011. Although all 17 natural derivatives share the same C-14 polyketide backbone, they exhibit a fairly broad structural diversity regarding their oxygenation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb089f152cc921043fe94a7bd859844a
https://pubmed.ncbi.nlm.nih.gov/30777758
https://pubmed.ncbi.nlm.nih.gov/30777758
Autor:
Christian B. W. Stark, Gunnar Ehrlich
Publikováno v:
Organic letters. 18(19)
A total synthesis of cytospolide D, starting from l-glutamic acid, is described. The critical macrolactonization to the 10-membered lactone containing an (E)-configured double bond was successfully achieved by Shiina esterification. Conversion of cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3657a250a313d5d492cb3b4b699d12cc
https://pubmed.ncbi.nlm.nih.gov/27636302
https://pubmed.ncbi.nlm.nih.gov/27636302
Autor:
Markus Kalesse, Mingzhao Zhu, Yazh Muthukumar, Ulrike Eggert, Nina Diaz, Gunnar Ehrlich, Florenz Sasse
Publikováno v:
Chemistry – A European Journal. 18:4946-4952
The improved synthesis of the antitumor compound (+)-tedanolide is described through an aldol coupling of bis-ketone 7. This modification shortens the synthetic steps in the endgame and provides rapid access to this biologically important natural pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c70423dd7a75de72cf402aab2f16a5
https://doi.org/10.1002/chem.201103038
https://doi.org/10.1002/chem.201103038
Publikováno v:
Angewandte Chemie. 123:3979-3981
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3b550e0f9c4d1732bafe9af5d9f8b69
https://doi.org/10.1002/ange.201007448
https://doi.org/10.1002/ange.201007448
Publikováno v:
Angewandte Chemie International Edition. 50:3892-3894
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0473e8fb91ccfa352a5cebb24213f08
https://doi.org/10.1002/anie.201007448
https://doi.org/10.1002/anie.201007448
Autor:
Markus Kalesse, Gunnar Ehrlich
Publikováno v:
Synlett. :655-657
The synthesis of the C13-C23 segment of tedanolide is described making use of orthogonal protecting groups in the construction of the carbon skeleton and for the selective liberation of hydroxyl groups in the endgame of the total synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd290078ce52018bdb1fc57777c3a29
https://doi.org/10.1055/s-2005-862391
https://doi.org/10.1055/s-2005-862391
Publikováno v:
Integrated environmental assessment and management. 7(4)
The identification and regulation of substances that combine persistence, bioaccumulation potential, and toxicity (“PBT” substances) is one central aspect of the European chemical legislation REACH (Registration, Evaluation, Authorisation, and Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0281a91668d7650fc6ae85e7ab9c72fb
https://pubmed.ncbi.nlm.nih.gov/21438133
https://pubmed.ncbi.nlm.nih.gov/21438133
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 14(7)
Tedanolide, which was isolated by Schmitz in 1984 from the marine sponge Tedania ignis, is a highly cytotoxic macrolide leading to strong growth inhibition of P338 tumor cells in bioassays. A unique structural feature of the known tedanolides is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e683681edb3724584a231c8475c31158
https://pubmed.ncbi.nlm.nih.gov/18165955
https://pubmed.ncbi.nlm.nih.gov/18165955
Publikováno v:
Journal of the American Chemical Society. 128(43)
The first total synthesis of the (+)-tedanolide is described. Pivotal steps are the Felkin-selective aldol coupling between C12 and C13 and an efficient Mitsunobu macrolactonization. Selective protecting group transformations and subsequent oxidation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5674de7caee90cfdd521a12ccab47b06
https://pubmed.ncbi.nlm.nih.gov/17061881
https://pubmed.ncbi.nlm.nih.gov/17061881