Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Gunnar Cedersund"'
Autor:
Sophie Rigal, Belén Casas, Kajsa P. Kanebratt, Charlotte Wennberg Huldt, Lisa U. Magnusson, Erik Müllers, Fredrik Karlsson, Maryam Clausen, Sara F. Hansson, Louise Leonard, Jonathan Cairns, Rasmus Jansson Löfmark, Carina Ämmälä, Uwe Marx, Peter Gennemark, Gunnar Cedersund, Tommy B. Andersson, Liisa K. Vilén
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-23 (2024)
Abstract Current research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with standard in vitro assays. Here, we have connected cell models of key metabolic organs, the pancreas and liv
Externí odkaz:
https://doaj.org/article/6ef35220f5cb430495895d01dab6b095
Autor:
Henrik Podéus, Christian Simonsson, Patrik Nasr, Mattias Ekstedt, Stergios Kechagias, Peter Lundberg, William Lövfors, Gunnar Cedersund
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract Alcohol consumption is associated with a wide variety of preventable health complications and is a major risk factor for all-cause mortality in the age group 15-47 years. To reduce dangerous drinking behavior, eHealth applications have shown
Externí odkaz:
https://doaj.org/article/497f6a94a18c45959cbf135c32b0e9c3
Autor:
Patrik Nasr, Mikael Forsgren, Wile Balkhed, Cecilia Jönsson, Nils Dahlström, Christian Simonsson, Shan Cai, Anna Cederborg, Martin Henriksson, Henrik Stjernman, Martin Rejler, Daniel Sjögren, Gunnar Cedersund, Wolf Bartholomä, Ingvar Rydén, Peter Lundberg, Stergios Kechagias, Olof Dahlqvist Leinhard, Mattias Ekstedt
Publikováno v:
BMC Gastroenterology, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Liver cirrhosis, the advanced stage of many chronic liver diseases, is associated with escalated risks of liver-related complications like decompensation and hepatocellular carcinoma (HCC). Morbidity and mortality in cirrhosis pat
Externí odkaz:
https://doaj.org/article/827a5b3938b54e0ea768519d24f890db
Autor:
Tilda Herrgårdh, Christian Simonsson, Mattias Ekstedt, Peter Lundberg, Karin G. Stenkula, Elin Nyman, Peter Gennemark, Gunnar Cedersund
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 15, Iss 1, Pp 1-20 (2023)
Abstract Background The increased prevalence of insulin resistance is one of the major health risks in society today. Insulin resistance involves both short-term dynamics, such as altered meal responses, and long-term dynamics, such as the developmen
Externí odkaz:
https://doaj.org/article/513807bc153f4c39b36e53a19c7af91a
Autor:
Gustav Magnusson, Maria Engström, Charalampos Georgiopoulos, Gunnar Cedersund, Lovisa Tobieson, Anders Tisell
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionCerebrovascular reactivity imaging (CVR) is a diagnostic method for assessment of alterations in cerebral blood flow in response to a controlled vascular stimulus. The principal utility is the capacity to evaluate the cerebrovascular rese
Externí odkaz:
https://doaj.org/article/27a4fdc4f4544feb804511be68a4c3fa
Autor:
William Lövfors, Rasmus Magnusson, Cecilia Jönsson, Mika Gustafsson, Charlotta S. Olofsson, Gunnar Cedersund, Elin Nyman
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Adipocyte signaling, normally and in type 2 diabetes, is far from fully understood. We have earlier developed detailed dynamic mathematical models for several well-studied, partially overlapping, signaling pathways in adipocytes. Still, thes
Externí odkaz:
https://doaj.org/article/cc9cf96f241a478db28a7eef0063ae70
Autor:
Durrieu Lucía, Bush Alan, Grande Alicia, Johansson Rikard, Janzén David, Andrea Katz, Gunnar Cedersund, Colman-Lerner Alejandro
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105906- (2023)
Summary: Nuclear transport is an essential part of eukaryotic cell function. Here, we present scFRAP, a model-assisted fluorescent recovery after photobleaching (FRAP)- based method to determine nuclear import and export rates independently in indivi
Externí odkaz:
https://doaj.org/article/3ccb05e020fa43939331b67799e6bdd2
Autor:
Sebastian Sten, Henrik Podéus, Nicolas Sundqvist, Fredrik Elinder, Maria Engström, Gunnar Cedersund
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010818 (2023)
Neurons regulate the activity of blood vessels through the neurovascular coupling (NVC). A detailed understanding of the NVC is critical for understanding data from functional imaging techniques of the brain. Many aspects of the NVC have been studied
Externí odkaz:
https://doaj.org/article/fdfe806078ce49f7b8f86518e302d085
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0279168 (2023)
BackgroundDrug induced liver injury (DILI) is a major concern when developing new drugs. A promising biomarker for DILI is the hepatic uptake rate of the contrast agent gadoxetate. This rate can be estimated using a novel approach combining magnetic
Externí odkaz:
https://doaj.org/article/0ea981b0cc334023ab1079aaa1036ed1
Autor:
Nicolas Sundqvist, Sebastian Sten, Peter Thompson, Benjamin Jan Andersson, Maria Engström, Gunnar Cedersund
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 12, p e1010798 (2022)
The neurovascular and neurometabolic couplings (NVC and NMC) connect cerebral activity, blood flow, and metabolism. This interconnection is used in for instance functional imaging, which analyses the blood-oxygen-dependent (BOLD) signal. The mechanis
Externí odkaz:
https://doaj.org/article/7c4c2c4f6ce047748aea54b445f06a5a